A5033082004- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Salivary Gland Disorders and Functions
- Mesenchymal stem cell research
- Effects of Radiation Exposure
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Cervical Cancer and HPV Research
- Electrospun Nanofibers in Biomedical Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tissue Engineering and Regenerative Medicine
- Travel-related health issues
- Radiology practices and education
- Rabies epidemiology and control
- Oral Health Pathology and Treatment
- Brain Metastases and Treatment
- Hidradenitis Suppurativa and Treatments
- Animal testing and alternatives
- Amoebic Infections and Treatments
- Lung Cancer Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
Copenhagen University Hospital
2022-2025
Rigshospitalet
2013-2025
University of Copenhagen
2009-2023
Frederiksberg Hospital
2022-2023
Parker Institute for Cancer Immunotherapy
2023
Evidence Based Research (United States)
2023
Hvidovre Hospital
2011
Roskilde Sygehus
2009-2011
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following guideline development process as outlined in Methodology Manual . follow Conflict Interest Policy Clinical Practice other guidance (“Guidance”) provided by is not a or definitive guide to treatment options. It intended voluntary use providers should be used conjunction independent professional judgment. Guidance may applicable all patients,...
Journal Article A double‐blind placebo‐controlled randomized trial of adalimumab in the treatment hidradenitis suppurativa Get access I. Miller, Miller Department Dermatology, Roskilde Hospital, Health Sciences Faculty, University Copenhagen, 4000, Denmark Iben Miller. E‐mail: miller@dadlnet.dk Search for other works by this author on: Oxford Academic Google Scholar C.D. Lynggaard, Lynggaard S. Lophaven, Lophaven C. Zachariae, Zachariae Gentofte D.N. Dufour, Dufour G.B.E. Jemec British...
ABSTRACT Purpose Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to head and neck. With over 9 published definitions at least 16 diagnostic/staging systems, true incidence severity ORNJ are obscured lack standard for definition assessment, leading inaccurate estimation incidence, reporting ambiguity, likely under-diagnosis worldwide. This study aimed achieve consensus on an explicit phenotype related precursor...
No effective treatment exists for radiation-induced xerostomia. The objective of this study was to compare the effect adipose-derived mesenchymal stem/stromal cell (ASC) injection, relative placebo, on salivary gland function in patients with
Abstract No effective therapy exists for the most common long-term side effect of radiation head and neck cancer (HNC)—xerostomia. The objective was to evaluate safety provide proof concept efficacy allogeneic adipose tissue-derived mesenchymal stem/stromal cells (AT-MSCs) injected into major salivary glands irradiated patients. This open-label, first-in-human, phase 1b, single-center trial conducted with repeated measurements days 0, 1, 5, 30 4 months. Eligible patients subjective signs...
Abstract Purpose: Mesenchymal stem/stromal cell therapy may reduce radiation-induced xerostomia. We investigated the long-term safety of autologous adipose tissue-derived mesenchymal (ASC) injections into submandibular glands. Experimental Design: An investigator-initiated, randomized, single-center, placebo-controlled trial. Previous patients with oropharyngeal squamous carcinoma xerostomia were randomly (1:1) allocated to receive a 2.8 million ASCs/cm3 injection or placebo in both glands...
Background. The post-treatment follow-up is well-integrated in the oncologic care tradition, based on risk of developing recurrent disease or new primary tumors treated patients. Furthermore, serves as an opportunity to monitor treatment effects and provide clinical side effects. In this study we measured activity effectiveness routine head neck cancer assessed value from perspectives both physicians Patients methods. During a period six weeks prospective national cross section cohort 619...
Abstract Background: The long-term effect of adipose-derived mesenchymal stromal cells (ASCs) to restore radiation-induced salivary gland hypofunction in previous head and neck cancer patients have not been validated larger settings. Methods: study was the 12-months follow-up a randomised trial, including with hyposalivation. Patients were receive allogeneic ASCs or placebo submandibular glands. Primary endpoint unstimulated whole saliva (UWS) followed by stimulated saliva, patient-reported...
<p>Supplementary Data 1</p>
<div>AbstractPurpose:<p>The long-term effect of adipose-derived mesenchymal stromal cells (ASC) on restoring radiation-induced salivary gland hypofunction in patients with previous head and neck cancer has not been validated larger settings.</p>Patients Methods:<p>The study was a 12-month follow-up randomized trial, including hyposalivation. Patients were to receive allogeneic ASC or placebo the submandibular glands. The primary endpoint unstimulated whole saliva...
Abstract Background Adipose-derived mesenchymal stem/stromal cells (ASCs) are proposed as a new xerostomia treatment. The study evaluated the long-term safety and effectiveness of allogeneic ASCs in radiation-induced among patients with previous oropharyngeal cancer. Methods This constitutes 3-year follow-up on original 10 who received injections to submandibular parotid glands part MESRIX-II trial. trial included preliminary 4-month follow-up. primary endpoint was safety. Secondary...
The adipose tissue-derived stromal vascular fraction (SVF) is a promising candidate for use in cell therapy and tissue engineering due to its regenerative immunomodulatory properties. Some therapies are based on using the complete SVF product, whereas others depend expansion of adipose-derived cells (ASCs) culture. latter application often involves time delay between harvest isolation. This study investigated how storage temperature affected quality composition. Aliquots lipoaspirate were...
Hyposalivation and xerostomia (dry mouth), are the leading site-effects to treatment of head neck cancer. Currently, there no effective therapies alleviate radiation-induced hyposalivation. Adipose tissue-derived mesenchymal stem/stromal cells (AT-MSCs) have shown potential for restoring salivary gland function. However, mode action is unknown. The purpose present study was therefore characterize effect AT-MSC therapy on proteome in previously irradiated cancer patients.Whole saliva...