A5013945752- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Bone fractures and treatments
- Cardiac Structural Anomalies and Repair
- Cancer, Stress, Anesthesia, and Immune Response
- Renal and related cancers
- Renal cell carcinoma treatment
- Nanoplatforms for cancer theranostics
- Drug-Induced Hepatotoxicity and Protection
- Cancer therapeutics and mechanisms
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- Pharmacogenetics and Drug Metabolism
- Ferroptosis and cancer prognosis
- Shoulder and Clavicle Injuries
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Analysis
- Vagus Nerve Stimulation Research
- Elbow and Forearm Trauma Treatment
- Soft Robotics and Applications
- Chemotherapy-induced organ toxicity mitigation
- Cancer Cells and Metastasis
- Robot Manipulation and Learning
Taipei Medical University-Shuang Ho Hospital
2023-2024
Texas Christian University
2024
Baylor Scott & White All Saints Medical Center
2023-2024
Oregon Health & Science University
2007-2024
University of California, Berkeley
2024
City of Hope
2016
City Of Hope National Medical Center
2012-2013
University of Cincinnati
1997
Cincinnati VA Medical Center
1997
Renal cell carcinoma (RCC) metastasis portends a poor prognosis and cannot be reliably predicted. Early determination of the metastatic potential RCC may help guide proper treatment. We analyzed microRNA (miRNA) expression in clear (ccRCC) for purpose developing miRNA signature to determine risk prognosis. used microarray technology profile 78 benign kidney ccRCC samples. Using 28 localized specimens as training cohort univariate logistic regression score methods, we developed model which...
Abstract Immunohistochemical expression of napsin A in primary pulmonary mucinous tumors is not well established. Napsin immunoreactivity was evaluated 43 mucin-producing adenocarcinomas the lung consisting 18 formerly classified as bronchioloalveolar carcinoma, 15 colloid adenocarcinomas, 5 solid predominant with mucin production, and signet ring cell features, 25 extrapulmonary different anatomic sites. thyroid transcription factor 1 (TTF-1) also compared. Thirty-three percent exhibited...
Evidence is accumulating to support the presence of P2X purinergic receptors in heart. However, biological role this receptor remains be defined. The objectives here were determine cardiac modulating progression post-myocardial infarction ischemic heart failure and investigate underlying mechanism. 4 (P2X R) an important subunit native receptors, cardiac-specific transgenic overexpression R (Tg) was developed as a model. Left anterior descending artery ligation resulted similar infarct size...
Matriptase-2 (MT2), encoded by TMPRSS6, is a membrane-anchored serine protease. It plays key role in iron homeostasis suppressing the iron-regulatory hormone, hepcidin. Lack of functional MT2 results an inappropriately high hepcidin and iron-refractory iron-deficiency anemia. Mt2 cleaves multiple components hepcidin-induction pathway vitro. inhibited protease inhibitor, Hai-2. Earlier vivo studies show that can suppress expression independently its proteolytic activity. In this study, our...
The use of high-dose acetaminophen (AAP) with n-acetylcysteine (NAC) rescue was studied as an anti-cancer treatment in phase I trials promising signals anti-tumor efficacy. Correlative analysis suggested that AAP has a free-radical-independent mechanism activity—in contrast to the well-established hepatotoxicity. Subsequent “reverse translational” studies pre-clinical setting have identified novel mechanisms action AAP, including modulation JAK-STAT signaling both tumor cell and immune...
(1) Background: Proximal humerus fractures can be a debilitating condition if not properly treated. These fracture patterns are varied and differ in every patient. Functional outcomes may determined by the integrity of shoulder girdle involving rotator cuff insertion. The post-operative resorption or malreduction greater tuberosity (GT) is an important factor contributing to poor functional outcome Thus, we intend evaluate cause-and-effect relationship between GT complications clinical...
Burst fractures are common in thoracolumbar spinal injuries, often resulting vertebral collapse with or without neurological deficits. While traditional open surgery is the standard approach for surgical decompression, it has some drawbacks and complications. Conversely, full endoscopic spine remains underexplored these patients. This case report presents a 77-year-old patient an L3 burst fracture severe deficits caused by retropulsion bone fragments, leading to canal compromise right L3–4...
Abstract Immunotherapy targeting the programmed cell death ligand 1/programmed protein 1 (PD-L1/PD-1) pathway using antibodies is clinically effective in treating a spectrum of cancers. Acetaminophen (AAP) has shown antitumor and/or chemo-enhancing effects human cancer cells vitro and vivo. We investigated AAP exposure on cells’ immune checkpoint PD-L1 expression their vivo tumorigenic ability. (10 mM) alone for 2 hr no effect viability level A2058 melanoma H460 non-small lung carcinoma...
612 Background: Clear cell renal carcinoma (ccRCC) metastasis is associated with a dismal prognosis. Early identification of patients at high or low risk may help to guide appropriate treatment. There are currently no reliable clinico-pathologic and laboratory modalities for this purpose in routine clinical setting. We previously performed microarray study using frozen ccRCC specimens identified dysregulation 4 microRNAs (miRNAs), miR-10b, miR-139-5p, miR-130b miR-199b-5p, be highly Methods:...
Abstract Brain metastases from systemic cancers occur in approximately 20% of lung cancer patients including both small cell carcinoma (SCLC) and non–small-cell (NSCLC), 5-8% breast melanoma. tend to present as multiple brain lesions with high morbidity poor prognosis. We investigated the expression αV integrin adhesion protein human lines (3 SCLC, 4 NSCLC, 2 melanoma, 1 cancer), its correlation migration vitro metastatic ability vivo using a hematogenous metastasis technique which cells are...
Abstract Chemoresistance is commonly found in treating cancer patients. Acetaminophen enhances the cytotoxicity of cisplatin human liver cells by depleting glutathione and increasing production toxic metabolites vitro. The objective this study was to investigate potential molecular mechanisms for chemoenhancement non-hepatic cells. Human ovarian carcinoma SKOV3 were treated with or paclitaxel without acetaminophen Cellular mitochondrial membrane reactive oxygen species concentration measured...
Abstract Purpose: To determine the efficacy of cisplatin treatment when enhanced by high dose acetaminophen (APAP) and followed N-acetylcysteine (NAC) rescue in a nude rat model medulloblastoma. Methods: Human medulloblastoma (DAOY) cells were inoculated into cerebellum female athymic rats (rnu/rnu). On day 10, randomized to groups (n = 6 per group): (1) saline controls; (2) IP 2 mg/kg; (3) PO APAP 600 mg/kg + cisplatin; (4) NAC 1 g/kg. All treatments given twice week for two weeks....
Abstract Acetaminophen (AAP) has been shown to enhance cisplatin (CDDP) cytotoxicity in hepatoblastoma cell lines. Further, one published case report demonstrated clinical efficacy of administering acetaminophen conjunction with and followed 6 hours later n-acetylcysteine (NAC) rescue. In this study, atypical rhabdoid tumor (ATRT) germinoma cells were treated CDDP AAP or without NAC We then evaluated the western blots for cleaved PARP caspase 3 demonstrate effects on apoptosis. MTS assays...
Objective: Non-ablative Ionizing radiation ( XRT) is well known to alter neuro-vascular unit (NVU) permeability. We evaluate the use of XRT enhance delivery intravenously administered Morpholino Oligonucleotides designed silence O6-methylguanine DNA methyltransferase (MGMT) in a MGMT expressing human derived brain tumor xenograft model. Background: MGMT, key repair enzyme associated with resistance temozolomide (TMZ). have previously reported non-ablative dose ionizing (XRT) prime cancer...
Abstract Overexpression of O6-methylguanine DNA methyltransferase (MGMT) contributes to brain tumor chemo-resistance. Previously we found that non-cytotoxic radiation improved anti-MGMT Morpholino Oligonucleotides (AMONs) delivery reduce MGMT levels in subcutaneous xenografts. Here evaluated if enhanced the intravenous (IV) AMONs rat and chemo-radiation therapy (CRT) efficacy using models human tumors. Athymic nude rats bearing orthotopic cerebellar D283 medulloblastoma or intracerebral H460...