A5037758723- Neurological disorders and treatments
- Schizophrenia research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurological and metabolic disorders
- Electroconvulsive Therapy Studies
- Psychosomatic Disorders and Their Treatments
- Child Nutrition and Feeding Issues
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Epilepsy research and treatment
- Genomics and Rare Diseases
- Obsessive-Compulsive Spectrum Disorders
- Digital Mental Health Interventions
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Parkinson's Disease and Spinal Disorders
- Restless Legs Syndrome Research
- Health Policy Implementation Science
- Chronic Disease Management Strategies
- Neural and Behavioral Psychology Studies
- Genetic Neurodegenerative Diseases
GGz centraal
2013-2024
Maastricht University
2013-2024
Maastricht University Medical Centre
2012-2021
European Graduate School of Neuroscience
2011-2013
University Medical Center Utrecht
2013
Utrecht University
2013
University Medical Center Groningen
2008-2009
Parnassia Groep
2009
's Heeren Loo
1996
University of Curaçao
1991-1992
Although anorexia nervosa was once thought to occur only in affluent societies, cases have now been documented across the globe. To examine whether emerges societies undergoing socioeconomic transition, authors studied incidence of on Caribbean island Curaçao.
The aim of this study was to investigate what extent atypical antipsychotics, conventional antipsychotics and anticholinergics are prescribed simultaneously in daily clinical practice Europe.A pharmaco-epidemiological carried out which hospital pharmacists from 45 hospitals Belgium, Denmark, France, Germany, Netherlands Scotland participated. Prescription data for 2,725 patients (mainly inpatients) who had been using an antipsychotic more than 6 weeks were analysed.The frequencies...
Abstract The scandal of premature mortality in people with serious mental illness is well established. Despite an increase studies evaluating the efficacy lifestyle interventions, translating this evidence into routine clinical care and policies challenging, part due to limited effectiveness or implementation research. We highlight challenge that increasingly recognized practice, advocate for adopting science study systematic update effective interventions practice policy, provide directions future
Despite an increase in studies showing the efficacy of lifestyle interventions improving poor health outcomes for people with severe mental illness (SMI), routine implementation remains ad hoc. Recently, a multidisciplinary enhancing treatment inpatients SMI (MULTI) was implemented as part care at long-term inpatient facility Netherlands, resulting significant improvements after 18 months. The current study aimed to identify barriers and facilitators its implementation.Determinants...
Objective The purpose of this study was to assess the frequency persistent drug-induced movement disorders namely, tardive dyskinesia (TD), parkinsonism, akathisia and dystonia in a representative sample long-stay patients with chronic severe mental illness. Method Naturalistic 209, mainly white, antipsychotic-treated patients, mostly diagnosed psychotic disorder. Of group, same rater examined 194 at least two times over 4-year period, mean follow-up time 1.1 years, validated scales for TD,...
To test the efficacy of current treatment recommendations for parkinsonism and tardive dyskinesia (TD) severity in patients with severe mental illness (SMI).We present an 18-year prospective study including all 223 SMI (as defined by 1987 US National Institute Mental Health, which were based on DSM-III-R diagnostic criteria) receiving care from only psychiatric hospital former Netherlands Antilles. Eight clinical assessments (1992-2009) focused movement disorders medication use. Tardive was...
Bradykinesia is associated with reduced quality of life and medication non-compliance, it may be a prodrome for schizophrenia. Therefore, screening/monitoring subtle bradykinesia clinical scientific importance. This study investigated the validity reliability such an instrument. Included were 70 patients psychotic disorders. Inertial sensors captured mean cycle duration, amplitude velocity four movement tasks: walking, elbow flexion/extension, forearm pronation/supination leg agility. The...
We studied the association between polymorphisms of genes coding for dopamine D(2) (DRD2), D(3) (DRD3), serotonin 2(a) (HTR2A), and 2(c) (HTR2C) receptors Antipsychotic-Induced Parkinsonism (AIP), rigidity, bradykinesia, rest-tremor in African-Caribbeans treated with antipsychotics. Polymorphisms DRD2 (-141CIns/Del, TaqIA, 957C > T), DRD3 (Ser9Gly), HTR2A (-1438A G, 102T C, His452Tyr), HTR2C (-759C T, Cys23Ser) were determined according to standard protocols. The Unified Parkinson Disease...
Objective Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and dystonia, subtypes TD (orofacial limb truncal dyskinesia), parkinsonism (rest tremor, rigidity, bradykinesia), as well a principal-factor the disorders their subtypes, were examined for association with variation in 7 candidate genes (GRIN2B, GRIN2A, HSPG2, DRD3, DRD4, HTR2C, NQO1). Methods Naturalistic study 168 white long-stay patients chronic mental illness requiring...
Objective Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and dystonia, subtypes TD (orofacial limb truncal dyskinesia), parkinsonism (rest tremor, rigidity, bradykinesia), as well a principal-factor the disorders their subtypes, were examined for association with variation in 10 candidate genes (PPP1R1B, BDNF, DRD3, DRD2, HTR2A, HTR2C, COMT, MnSOD, CYP1A2, RGS2). Methods Naturalistic study 168 white long-stay patients chronic mental...
Abstract Recent studies demonstrate an association between antipsychotic‐induced parkinsonism (AIP) and rs4606 SNP of RGS2 gene in Jewish African‐Americans. The current study investigates the AIP or its subsymptoms (rest tremor, rigidity, bradykinesia) 112 psychiatric inpatients African‐Caribbean origin. Presence AIP, bradykinesia, tremor was measured by UPDRS. We applied χ 2 (or Fisher Exact) logistic regression analyses several models including rs4606, age, gender, dose antipsychotics,...
Bradykinesia, a common symptom in psychiatry, is characterized by reduced movement speed and amplitude. Monitoring for bradykinesia important, as it has been associated with reductions quality of life medication compliance. Subtle forms have treatment response antipsychotic-naïve first episode patients. Therefore, accurate reliable assessment clinical importance. Several mechanical electronic instruments developed this purpose. However, their content validity limited. This study investigated...
Objective. Constipation is a prevalent problem in patients with psychiatric disorders; it reduces quality of life and may lead to severe complications. The prevalence distribution constipation across all diagnoses mental illness (SMI) has hardly been studied. aim this study estimate the association between disorders SMI inpatients. Methods. strength (based on use laxatives) DSM-IV diagnosis was studied cross-sectional "adjustment disorders" as reference group. analyzed using logistic...
Sleep disorders and reduced physical activity are common in patients with psychosis can be related to health-related outcomes such as symptomatology functioning. Mobile health technologies wearable sensor methods enable continuous simultaneous monitoring of activity, sleep, symptoms one's day-to-day environment. Only a few studies have applied assessment these parameters. Therefore, we aimed examine the feasibility functioning psychosis.Thirty three outpatients diagnosed schizophrenia or...
Background Work-related stress and burnout remain common problems among employees, leading to impaired health higher absenteeism. The use of mobile apps promote well-being has grown substantially; however, the impact such on reducing preventing is limited. Objective This study aims assess effectiveness STAPP@Work, a mobile-based management intervention, perceived stress, coping self-efficacy, level mental employees. Methods used single-case experimental design examine STAPP@Work employees...
<b><i>Aims:</i></b> This cross-sectional study investigates<b> </b>the effect of antipsychotic (AP)-induced hyperprolactinemia on testosterone, luteinizing hormone (LH), follicle-stimulating (FSH), inhibin B, and puberty in boys with mainly autism spectrum disorders (ASD). <b><i>Method:</i></b> One hundred four physically healthy 10- to 19-year-old ASD or disruptive behavior disorder (DBD) were recruited between October 2006...
Predicting what will happen in the future terms of potential reward is essential daily life. The aim current study was to investigate neurotransmitter systems involved anticipation value and probability. We hypothesized that dopaminergic noradrenergic antagonism would affect probability, respectively. Twenty-three healthy participants were included a haloperidol (2 mg) × clonidine (0.150 placebo cross-over design subjected Go/NoGo experimental task during which cues signaled probability...