A5061684647- Protein Structure and Dynamics
- Enzyme Structure and Function
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- Renal and related cancers
- thermodynamics and calorimetric analyses
- ICT Impact and Policies
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Computational Drug Discovery Methods
- Urological Disorders and Treatments
- S100 Proteins and Annexins
- Inorganic and Organometallic Chemistry
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Enzyme Production and Characterization
- Pediatric Urology and Nephrology Studies
- Mass Spectrometry Techniques and Applications
- Organometallic Complex Synthesis and Catalysis
- Renal cell carcinoma treatment
- Advanced Battery Technologies Research
- Heat shock proteins research
- Bacterial Genetics and Biotechnology
- Signaling Pathways in Disease
- Renal and Vascular Pathologies
Georgia State University
2025
University of Warwick
2018-2024
Birkbeck, University of London
2010-2023
Institute of Structural and Molecular Biology
2010-2023
University College London
1994-2021
Furness General Hospital
2021
University of London
2021
North Devon District Hospital
2021
Virginia Tech
2019
University of Manchester
2015-2016
Abstract We present a CPU efficient protocol for refinement of protein structures in thin layer explicit solvent and energy parameters with completely revised dihedral angle terms. Our approach is suitable determined by theoretical (e.g., homology modeling or threading) experimental methods NMR). In contrast to other recently proposed protocols, we put strong emphasis on consistency widely accepted covalent computational efficiency. illustrate the method NMR structure calculations three...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical-enzymic synthesis and conformational analysis of sialyl Lewis X derivativesYoshitaka Ichikawa, Ying Chih Lin, David P. Dumas, Gwo Jenn Shen, Eduardo Garcia-Junceda, Mark A. Williams, Robert Bayer, Catherine Ketcham, Leslie E. Walker, Cite this: J. Am. Chem. Soc. 1992, 114, 24, 9283–9298Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November...
Abstract We have analyzed the buried water molecules and internal cavities in a set of 75 high‐resolution, nonhomologous, monomeric protein structures. The number hydrogen bonds formed between each molecule varies from 0 to 4, with 3 being most common. Nearly half are found pairs or larger clusters. Approximately 90% shown be associated large within protein, as determined by novel program, PRO_ACT. total volume protein's is proportional its molecular weight not dependent on structural class....
Human lysosome membrane glycoprotein h-lamp-1 is a highly N-glycosylated protein found predominantly in lysosomes, with low levels present at the cell surface. The signal required for delivery of to lysosomes was investigated by analyzing intracellular distribution altered amino acid sequences expressed from mutated cDNA clones. A cytoplasmic tail tyrosine residue conserved chicken, rodent, and human deduced discovered be necessary efficient lysosomal transport COS-1 cells. In addition,...
Significance How enzymes acquire new functions is a key question in evolutionary biology. Here, we studied the evolution of some forms ribulose-1,5-bisphosphate carboxylase, enzyme responsible for CO 2 fixation photosynthesis, which has evolved enhanced activity multiple groups plants. We showed that this was constrained by tradeoffs between and stability, two properties enzymes. The acquisition mediated mutations destabilizing structure. However, these were preceded followed periods...
Abstract The extent of enthalpy–entropy compensation in protein–ligand interactions has long been disputed because negatively correlated enthalpy (Δ H ) and entropy ( T Δ S changes can arise from constraints imposed by experimental analytical procedures as well through a physical mechanism. To distinguish these possibilities, we have created quantitative models the effects on isothermal titration calorimetry (ITC) measurements. These are found to obscure any that may be present common data...
Li-ion cell designs, component integrity, and manufacturing processes all have critical influence on the safety of batteries. Any internal defective features that induce a short circuit, can trigger thermal runaway: cascade reactions, leading to device fire. As consumer manufacturers push aggressively for increased battery energy, instances field failure are increasingly reported. Notably, Samsung made press release in 2017 following total product recall their Galaxy Note 7 mobile phone,...
Approximately 5% of children with Wilms tumor present bilateral disease. The treatment challenge is to achieve a high cure rate while maintaining adequate long-term renal function. authors this report assessed the feasibility and outcome nephron-sparing surgery in patients who were treated at single institution.A retrospective review was performed all St. Jude Children's Research Hospital for synchronous, tumors from 1999 through 2006. Imaging studies, surgical techniques, pathology reports...
The membrane orientation of the NB protein influenza B virus, a small (Mr, approximately 18,000) glycoprotein with single internal hydrophobic domain, was investigated by biochemical and genetic means. Cell fractionation solubility studies indicate is an integral protein, has been shown to be dimer under nonreducing conditions. Treatment infected-cell surfaces proteinase K endoglycosidase F immunoprecipitation site-specific antibody suggests that 18-amino-acid NH2-terminal region exposed at...
Wilms tumor is the most common renal cancer in children. Approximately 5% of children with present disease both kidneys. The treatment challenge to achieve a high cure rate while maintaining long-term function. We retrospectively reviewed our institutional experience nephron sparing surgery (NSS) patients synchronous bilateral (BWT) operated on between 2001 and 2014.Imaging studies, surgical approach, adjuvant therapy, pathology reports were reviewed. Outcomes evaluated included...
Abstract Most of the literature on strikes has addressed one four issues: causation, variation between sectors and countries, trends over time relationship other forms collective individual protest. Very little research equally important questions strike outcomes trade union membership despite substantial body causes decline strategies for growth. In this paper we reverse usual sequence as a causal factor in genesis examine impact levels. After setting out relevant theory hypotheses, use...
C-to-U editing causes specific nucleotide changes in plant mitochondrial nRNAs that are required for the restoration of evolutionarily conserved amino acid sequence. Transcripts ribosomal protein S12 gene (rps12) have six sites and highly heterogeneous as a result incomplete editing. immunological analysis demonstrated unedited or partially edited transcripts well mRNAs translated. The rps12 translation products accumulate subunits, but present unassembled subunits not detected ribosomes....
The mRNA derived from influenza B virus RNA segment 6 is functionally bicistronic and encodes the NB NA glycoproteins in different, overlapping reading frames. protein synthesis initiated at 5'-proximal AUG codon, 4 nucleotides downstream there a second codon which used to initiate synthesis. nucleotide sequence context of first conforms closely with established 5'-CC(A/G)CCAUGG-3' consensus (M. Kozak, Nucleic Acids Res. 15:8125-8148, 1987), should favor initiation this site, yet are found...
No AccessJournal of UrologyStone1 Oct 2010Pediatric Urolithiasis—Does Body Mass Index Influence Stone Presentation and Treatment? Kathleen Kieran, Dana W. Giel, Brent J. Morris, Jim Y. Wan, Chrisla D. Tidwell, Andrew Giem, Gerald R. Jerkins, Mark A. Williams KieranKathleen Kieran , GielDana Giel MorrisBrent Morris WanJim Wan TidwellChrisla Tidwell GiemAndrew Giem JerkinsGerald Jerkins WilliamsMark View All Author Informationhttps://doi.org/10.1016/j.juro.2010.03.111AboutFull TextPDF ToolsAdd...