A5088558959- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Food Security and Health in Diverse Populations
- Erythrocyte Function and Pathophysiology
- Prenatal Screening and Diagnostics
- Vaccine Coverage and Hesitancy
- Chronic Lymphocytic Leukemia Research
- COVID-19 epidemiological studies
- COVID-19 Impact on Reproduction
- Bone and Joint Diseases
- Adolescent and Pediatric Healthcare
- Blood transfusion and management
- Childhood Cancer Survivors' Quality of Life
- Misinformation and Its Impacts
- Clinical Laboratory Practices and Quality Control
- Ethics and Legal Issues in Pediatric Healthcare
- Genetic Syndromes and Imprinting
- Blood donation and transfusion practices
- Mycobacterium research and diagnosis
- Autopsy Techniques and Outcomes
- HIV/AIDS Research and Interventions
Northwestern University
2018-2024
Lurie Children's Hospital
2019-2024
Northwestern Memorial Hospital
2020
Center for Cancer and Blood Disorders
2016
Children's National
2016
Abstract Background The acute respiratory illness designated coronavirus disease 2019 (COVID‐19) was first reported in Wuhan, China, December and caused a worldwide pandemic. Concerns arose about the impact of COVID‐19 pandemic on blood donations potential significant transfusion needs severely ill patients. Data usage hospitalized patients are scarce. Study Design Methods We performed retrospective observational study component transfusions 4 weeks ward admissions. period began 14 days...
Abstract Individuals with sickle cell disease (SCD) are at heightened risk of complications, hospitalization, and mortality due to SARS-CoV-2 (COVID-19) infection; however, there is hesitancy receive the COVID-19 vaccine a desire learn about directly from healthcare clinicians. The current study utilized community-engaged research methods co-design educational materials vaccines. Participants were adolescents adults SCD caregivers children SCD. proceeded in three phases: 1) focus...
Abstract Background We instituted RHD genotyping in our transfusion service for obstetrical patients and candidates. sought to examine how resolved weak or discrepant automated microplate direct agglutination (MDA) RhD phenotypings impacted needs Rh Immune Globulin (RhIG) D‐negative RBCs. Study Design Methods investigated phenotypes with equivocal reagent‐discrepant MDA (Immucor, Norcross, GA), weak‐2+ immediate‐spin tube typings, historically D+ typings anti‐D. performed microarray (RHD...
Abstract Background The patient‐centered medical home (PCMH) has been proposed as a model for comprehensive care coordination and delivery children with sickle cell disease (SCD), yet little is known regarding the implementation of PCMH core concepts on adherence to preventative measures, health utilization, parent satisfaction. Procedure We implemented newborn cohort clinic (NCC) explore application infants SCD from birth age 3 years in 2011. In July 2017, we conducted retrospective chart...
Summary We used near‐infrared spectroscopy to examine tissue oxygenation (StO 2) during exercise in 17 children and young adults with sickle cell anaemia (SCA) 13 controls. Patients had lower cerebral StO 2 at all stages demonstrated significantly greater decreases later exercise. Quadriceps increased similarly patients controls early exercise, but from baseline were At similar workloads, (69·2 ± 6·6 vs. 79·5 5·3%, P < 0·001) trended towards quadriceps (67·7 9·0 73·2 7·9%, = 0·09) Further...
Abstract Background For patients with weak or discrepant RhD RBC phenotypes, RHD genotyping is employed to determine need for RhD‐negative management. However, many variants are type D‐negative D‐positive. Serological recognition rates (RRs) of and partial poorly characterized. Study Design Methods Four US studies employing phenotypes provided data race/ethnicity‐specific serological recognition. Three used microplate, 1 gel tube; 2 had anti‐D data. We obtained White Hispanic/Latino allele...
Sickle cell disease (SCD), which occurs primarily in individuals of African descent, has been identified as a preexisting health condition for COVID-19 with higher rates hospitalization, intensive care unit admissions, and death. National data indicate Black have vaccine hesitancy lower vaccination rates. Understanding the key predictors intention to receive is essential strongly associated behavior. This multisite study examined attitudes, beliefs, intentions vaccines, educational...
Sickle cell disease (SCD) state level surveillance data are limited. We performed a retrospective review of emergency department (ED) visits and hospitalizations from individuals with SCD in Illinois (2016–2020) using the Health Hospital Association’s Comparative Care Data Reporting Services. There were 48,094 outpatient ED 31,686 hospitalizations. Most (67%) occurred Cook County, covered by public insurance (77%) medium high (40.3%) or (36.1%) poverty levels. healthcare utilization remains...