A5004150186- Advanced Machining and Optimization Techniques
- Advanced machining processes and optimization
- Advanced Surface Polishing Techniques
- Surface Treatment and Coatings
- Metal and Thin Film Mechanics
- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Reactions
- Memory and Neural Mechanisms
- Advanced materials and composites
- Advanced ceramic materials synthesis
- Energetic Materials and Combustion
- Synthesis and Catalytic Reactions
- Synthetic Organic Chemistry Methods
- Particle physics theoretical and experimental studies
- Catalytic Cross-Coupling Reactions
- Vanadium and Halogenation Chemistry
- Injection Molding Process and Properties
- Industrial Vision Systems and Defect Detection
- Fluorine in Organic Chemistry
- Metal Extraction and Bioleaching
- Dark Matter and Cosmic Phenomena
Japan Science and Technology Agency
2025
Kyoto University
2007-2025
Shizuoka Institute of Science and Technology
2015-2023
Saga University
1986-2023
RIKEN Center for Brain Science
2015-2021
Toagosei (Japan)
2021
Meijo University
2019
University of Science and Technology
2018
Shizuoka University
2018
Epson (United States)
2018
A new strategy for mixed biaryl synthesis has been developed using the hypervalent iodine(III) reagents. The unique reactivities of sigma-heteroaryl intermediates generated in situ are key element unusual metal catalyst-free transformations and strict control product selectivities.
Memories are initially encoded in the hippocampus but subsequently consolidated to cortex. Although synaptic plasticity is key these processes, its precise spatiotemporal profile remains poorly understood. Using optogenetics selectively erase long-term potentiation (LTP) within a defined temporal window, we found that distinct phases of play differential roles. The first wave acts locally confer context specificity. second wave, during sleep on same day, organizes neurons into synchronously...
New scoop on scope and selectivity: The hydration of organonitriles catalyzed by a RhI(OMe) species under nearly pH-neutral ambient conditions (25 °C, 1 atm) is chemoselective high-yielding (93 to 99 %), has broad substrate scope, may thus be complementary enzymatic methods for the introduction terminal amido group (CONH2) onto carbon chain.
We have found that unreactive and insoluble polymeric iodosobenzene [PhIO]n induced aqueous benzylic C−H oxidation to effectively give arylketones, in the presence of KBr montmorillonite-K10 (M-K10) clay. Water-soluble reactive species 1 having unique I(III)−Br bond, situ generated from KBr, was considered be key radical initiator during reactions.
We have developed a new and reliable method for the direct construction of biologically important aryl lactones phthalides from carboxylic benzoic acids, using combination hypervalent iodine(III) reagents with KBr.
Hypervalent iodine(III) reagents mediate the direct cyanating reaction of a wide range electron-rich heteroaromatic compounds such as pyrroles 1, thiophenes 3, and indoles 5 under mild conditions (ambient temperature), without need for any prefunctionalization. Commercially available trimethylsilylcyanide is usable stable effective cyanide source, proceeds in homogeneous system. The N-substituent crucial to avoid undesired oxidative bipyrrole coupling process, thus cyano group was introduced...
Significance Selection of actions that allow the seeking rewards and avoidance uncomfortable environments is a fundamental animal behavior. Here, we report an in vivo method, which activities PKA ERK were optically recorded by microendoscopy Förster resonance energy transfer responses biosensors distinct D1 D2 dopamine receptor-expressing neurons dorsal striatum. The coordinately but reciprocally regulated not only rewarding aversive stimuli also between two parallel projection neurons....
Cdc42 is a key regulator of dynamic actin organization. However, little known about how Cdc42-dependent regulation influences steady-state structures in differentiated epithelia. We employed inner ear hair cell (HC)-specific conditional knockout to analyze the role HCs possessing highly elaborate stable protrusions (stereocilia). Atoh1–Cre;Cdc42flox/flox mice developed normally but progressively degenerated after maturation, resulting progressive hearing loss particularly at high...
An aldol-type reaction of organonitriles with aldehydes was catalyzed by a RhI(OR) species under ambient conditions, and the displayed broad substrate scope respect to both organonitrile aldehyde components.
Rhodium to the rescue: The formal aldol products of carboxamides (CONH2) were obtained by using a RhI(OR) (R=H, Me) catalyst under essentially neutral pH and ambient conditions. This novel strategy is based on catalytic aldol-type reaction nitriles, followed hydration nitrile functionality (R1=aromatic or aliphatic, R2 R3=H alkyl; see scheme). Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited typeset....
Enteric neural crest-derived cells (ENCCs) migrate from the anterior foregut in a rostrocaudal direction to colonize entire gastrointestinal tract and form enteric nervous system. Genetic approaches have identified many signaling molecules regulating migration of ENCCs; however, it remains elusive how activities are regulated spatiotemporally during migration. In this study, transgenic mice expressing biosensors based on Förster resonance energy transfer were generated video activity changes...
Significance The nucleus accumbens (NAc) is a key neural substrate that controls aversive learning through D1 receptor-expressing direct pathway neurons and D2 indirect neurons. We explored how controlled by intracellular PKA signaling in these two types of the NAc. approached this issue not only pathway-specific inhibition either or neurons, but also microendoscopic analysis FRET responses biosensor distinctly expressed obtained consistent findings from different approaches, demonstrate...
Top in Breite und Selektivität: Die durch eine RhI(OMe)-Spezies katalysierte Hydratisierung von Organonitrilen bei fast neutralem pH-Wert Umgebungsbedingungen (25 °C, 1 atm) ist chemoselektiv effizient (93–99 % Ausbeute), hat ein breites Substratspektrum könnte so enzymatische Hydratisierungsmethoden der Einführung einer endständigen Amidogruppe (CONH2) Kohlenstoffkette ergänzen.
The second messenger cAMP plays a pivotal role in neurite/axon growth and guidance, but its downstream pathways leading to the regulation of Rho GTPases, centrally implicated neuronal morphogenesis, remain elusive. We examined spatiotemporal changes Rac1 Cdc42 activity phosphatidylinositol 3,4,5-triphosphate (PIP(3)) concentration dibutyryl (dbcAMP)-treated PC12D cells using Förster resonance energy transfer-based biosensors. During 30-min incubation with dbcAMP, gradually increased...
The physicochemical properties of deep eutectic solvents (DESs) depend on the combination hydrogen bond acceptors and donors used. basicity a DES significantly influences its performance in CO2 chemical absorption, biomass protein dissolution, catalytic reactions. To best our knowledge, strategy for fine-tuning DESs has not yet been reported. Therefore, this study, we substituted base urea (Ur) reline, which is 1:2 mixture choline chloride (ChCl) Ur, with superbase guanidine (Gu) to...
The structure and electronic nature of the phosphine have a significant influence on not only formation, but also subsequent transformation O,P-acetals. O,P-acetals generated from tris(o-tolyl)phosphine [(o-tol)3P] underwent efficient substitution reactions with various nucleophiles.
Highly substituted four- and five-membered heterocycles were prepared starting with O,P- N,P-acetals by using a one-pot method involving base induced cyclization Horner–Wadsworth–Emmons (HWE) olefination reaction. Divergent synthesis of various was achieved this transformations the alkenyl group in products these processes exemplified. Finally, short efficient (±)-pseudodeflectusin based on new methodology achieved.
In a developing nervous system, axon‐dendrite formation is instructed by extrinsic cues, and the mechanism whereby neuron interprets these cues using intracellular signaling particularly important. Studies dissociated hippocampal neurons have identified many pathways underlying neuronal polarization. Among components of pathways, Rap1B essential for axon specification in cultures. However, spatiotemporal regulation activity polarizing how it affects polarization remain unclear. Herein, we...
An unusual and novel reaction of α-alkoxyphosphonium salts, generated from O,O-acetals Ph3P, with Grignard reagents under an O2 atmosphere afforded alcohols in moderate to high yields. It was clarified by isotopic labelling experiments that the proceeded via a radical pathway.