A5075778817- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- Evaluation of Teaching Practices
- Education and Critical Thinking Development
- Student Assessment and Feedback
- Economic and Business Development Strategies
- Corporate Finance and Governance
- Leadership, Behavior, and Decision-Making Studies
- Chronic Lymphocytic Leukemia Research
- Protein Tyrosine Phosphatases
- Business and Economic Development
Lund University
2019
Chemical Synthesis Lab
2019
Galectins are a family of carbohydrate recognition proteins involved in, among other things, modulating cell signalling and cell-environment interactions, giving them roles in several pathologies like cancer idiopathic lung fibrosis. Hence, developing new galectin inhibitors with high affinity selectivity is important to be able target such diseases. Most existing have disaccharide scaffold, but there has been success as late monogalactoside α-arylthioglycosides. Here, we report...
Galectins are carbohydrate-recognizing proteins involved in many different pathological processes, including cancer and immune-related disorders. Inhibitors of galectins have evolved from natural oligosaccharides toward more drug-like truncated galactoside scaffolds that only retain key specific interactions the galactose with galectin carbohydrate recognition domains. In this context, C1-galactosides attractive stable scaffolds, work reports synthesis novel C1-galactopyranosyl heteroaryl...
The galectins are a family of galactose-binding proteins playing key roles in inflammatory processes and cancer. However, they structurally very closely related, discovery highly selective inhibitors is challenging. In this work, we report the design novel binding to subsite unique galectin-3, which confers both high selectivity affinity towards galectin-3. Olefin cross metathesis between allyl β-C-galactopyranosyl 1-vinylnaphthalenes or acylation aminomethyl with 1-naphthoic acid...
Galectins are carbohydrate recognition proteins that bind carbohydrates containing galactose and involved in cell signaling cellular interactions, involving them several diseases. We present the synthesis of (aryltriazolyl)methyl galactopyranoside galectin inhibitors using a highly diastereoselective hydroboration C1-exo-methylene pyranosides giving with fourfold or better selectivity for galectin-1 over galectin-3, -4C (C-terminal CRD), -4N (N-terminal -7, -8C, -8N, -9C, -9N dissociation...