A5033579092- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Bat Biology and Ecology Studies
- Animal Vocal Communication and Behavior
- Neuroscience and Neuropharmacology Research
- Marine animal studies overview
- Sleep and related disorders
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Animal Behavior and Reproduction
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Animal Ecology and Behavior Studies
- Sleep and Work-Related Fatigue
- Bariatric Surgery and Outcomes
- Human-Animal Interaction Studies
- Marine and fisheries research
- Data Visualization and Analytics
- Guidance and Control Systems
- Physiological and biochemical adaptations
- Genetic and phenotypic traits in livestock
- Congenital Heart Disease Studies
- Language Development and Disorders
University of California, San Diego
2023-2025
University of Oxford
2017-2025
UC San Diego Health System
2024-2025
University of California System
2024
Tel Aviv University
2021
Science Oxford
2019
Growing evidence suggests that brain activity during sleep, as well sleep regulation, are tightly linked with synaptic function and network excitability at the local global levels. We previously reported a mutation in synaptobrevin 2 (Vamp2) restless (rlss) mice results marked increase of wakefulness suppression particular REM (REMS), increased consolidation wakefulness. In this study, using finer-scale vivo electrophysiology recordings, we report spontaneous cortical rlss NREM (NREMS) is...
Aging markedly increases the risk of both Alzheimer's disease (AD) and obstructive sleep apnea (OSA). Memory deficits, an early indicator AD, can be reduced in middle-aged OSA sufferers through treatment, with positive-airway pressure being first line treatment standard. Here, we utilize natural variation severity older-aged cohort to investigate whether hypoxia or quality predict sleep-dependent memory consolidation (SDMC). Participants aged 65-85 years not currently receiving were...
Abstract Introduction Obesity is an important risk factor for obstructive sleep apnea (OSA) development. Likewise, obesity management component of OSA treatment. We evaluated the impact sleeve gastrectomy on endotypes in prospective and retrospective cohorts. Methods The SLIM-OSA trial (NCT04793334; IRB#191948) seeks to elucidate mechanisms why weight loss improves some but not all individuals. Participants underwent baseline polysomnography. Six months following gastrectomy, polysomnography...
Abstract Introduction Women show a higher prevalence of comorbid insomnia and sleep apnea (COMISA) Alzheimer’s disease (AD) than men. Episodic memory is sensitive to early AD-related changes may be particularly vulnerable fragmentation in COMISA. While women often outperform men verbal episodic memory, disturbances attenuate this. We hypothesized that those with COMISA would perform worse on without COMISA, the effects stronger Methods Ninety-two older adults (ages 65-83yrs) normal cognition...
Abstract Introduction Sleep-dependent declarative memory is negatively affected by obstructive sleep apnea (OSA) in middle-aged adults. Older age associated with deficits learning and cognition. Three age-related comorbidities that may contribute to this relationship are OSA, Alzheimer’s, weight gain. We hypothesize that, as adults, poorer health would be worse older Methods Seventy-nine adults (65-83 years; mean age=70; 44% female) were enrolled part of a larger study. Participants...
Bats, quoted as sleeping for up to 20 h a day, are an often used example of extreme sleep duration amongst mammals. Given that has historically been one the primary metrics featured in comparative studies sleep, it is important species specific durations well founded. Here, we re-examined evidence characterization bats sleepers and discuss whether provides useful representation behavior Chiroptera. Although there wealth activity data suggest diurnal cycle dominated by rest, estimates time...
Abstract Collective behaviours are widely assumed to confuse predators, but empirical support for a confusion effect is often lacking, and its importance must depend on the predator’s targeting mechanism. Here we show that Swainson’s Hawks Buteo swainsoni other raptors attacking swarming Mexican Free-tailed Bats Tadarida brasiliensis steer by turning towards fixed point in space within swarm, rather than using closed-loop pursuit of any one individual. Any prey with which predator collision...
Abstract Sleep is associated with many costs, but also important to survival, a lack of sleep impairing cognitive function and increasing mortality. Sleeping in groups could alleviate sleep‐associated or introduce new costs if social sleeping disrupts sleep. Working the Jamaican fruit bat ( Artibeus jamaicensis) , we aimed to: (1) describe architecture, (2) assess how affects sleep, (3) quantify total time identify rapid eye movement (REM) using behavioral indicators that complement...
Word finding difficulties are often seen in children with language difficulties. Their problem is readily observed and has led to investigations of its nature encouraged attempts at intervention. Semantic errors their naming suggest that knowledge items poorly developed therapies strengthen it may be effective. Twelve between 7 11 years age were offered 3 hours semantic therapy two 15-minute sessions per week for 6 weeks. The had severe complex speech, communication needs all the bottom 5%...
Abstract Vocalisations are increasingly being recognised as an important aspect of normal rodent behaviour yet little is known how they interact with other spontaneous behaviours such sleep and torpor, particularly in a social setting. We obtained chronic recordings the vocal adult male female Djungarian hamsters ( Phodopus sungorus ) housed under short photoperiod (8 h light, 16 dark, square wave transitions), different contexts. The animals were kept isolation or same-sex sibling pairs,...
Abstract Background During non-rapid eye movement sleep (NREM), alternating periods of synchronised high (ON period) and low (OFF neuronal activity are associated with amplitude delta band (0.5–4 Hz) oscillations in neocortical electrophysiological signals termed slow waves. As this oscillation is dependent crucially on hyperpolarisation cortical cells, there an interest understanding how silencing during OFF leads to the generation waves whether relationship changes between layers. A...
Brazilian free-tailed bats form large maternal colonies numbering in the millions across American Southwest. Each night, emerge from their roost to travel foraging locations. During this emergence, individuals fly together a dense, linear stream and exhibit collective group behavior. Upon morning return roost, flight behavior of change unpredictable paths, with little no apparent behavior, creating swarm. To understand different sensory challenges each these scenarios pose bats, we recorded...
ABSTRACT Growing evidence suggests that brain activity during sleep, as well sleep regulation, are tightly linked with synaptic function and network excitability at the local global levels. We previously reported a mutation in synaptobrevin 2 ( Vamp2 ) restless rlss mice results marked increase of wakefulness suppression particular REM (REMS) increased consolidation wakefulness. In current study, using finer-scale vivo electrophysiology recordings, we report spontaneous cortical NREM (NREMS)...
Chinstrap penguins fall asleep thousands of times per day in the wild.
Abstract Introduction Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated the pathogenesis of Alzheimer’s disease (AD). Sleep disruption a possible reversible cause memory impairment. Furthermore, quality determined to be one most important variables affecting overnight consolidation. As part larger study, data are presented evaluating correlations between markers severity sleep-dependent Methods Seventy-one ages 65-83 (M=70, SD=4.1) with normal cognition...
Abstract Introduction Obstructive sleep apnea (OSA) is associated with major neurocognitive sequalae including impaired memory. OSA patients are deficient in NREM spindles (11 Hz to 16 electroencephalography (EEG) sigma oscillations) which have been shown promote This finding a result of less time spent deeper states most occur but also reduction spindle density, particularly during the later portion night. We tested hypothesis that density deficiencies driven by restriction breathing...