Purpose . Hesperetin and naringenin are naturally common flavonoids reported to have antioxidative effects. This study was performed investigate whether either hesperetin or has a protective effect against apoptosis on retinal ischemia/reperfusion (I/R) injury. Methods Retinal I/R induced by increasing the intraocular pressure 150 mmHg for 60 minutes. Thirty-three male Wistar albino rats were randomised into 5 groups named control, + sham, solvent (DMSO), hesperetin, naringenin. Animals...

Purpose: This study aimed to investigate the effect of quercetin on apoptotic cell death induced by ischemia-reperfusion (I/R) injury in rat retina. Methods: Twenty-four rats were divided into four equal groups: control, ischemic, solvent, and quercetin. I/R was achieved elevating intraocular pressure above perfusion pressure. Intraperitoneal injections 20 mg/kg dimethyl sulfoxide (DMSO) performed solvent groups, respectively, immediately prior injury, researchers allowed for retinas be...

Purpose: The brain develops rapidly in early life, so sleep, media exposure and parental relationships are important topics for researchers during this period. aim of study was to examine the children aged 3-6 years, addition their sleep habits attitudes. Materials Methods: Participants descriptive study, based on relational screening model, were 70 boys (64.2%) 39 girls (35.8%) between 3 6 parents, who had been seen at child psychiatry outpatient clinic. used following data collection...

Background and Objective To compare the success, complication, patient discomfort rates of transcanalicular diode laser dacryocystorhinostomy (TCDL‐DCR) external (EX‐DCR) surgeries performed in patients with primary acquired nasolacrimal duct obstruction. Materials Methods Eighty consecutive were included study, groups assigned according to DCR technique. Thirty‐four (42.5%) received TCDL‐DCR (Group A) 46 (57.5%) B) EX‐DCR temporary silicone stent intubation. The success surgery was...

The aim of the study reported in this article was to determine presence and quantitative differences matrix metalloproteinase-2 (MMP-2), its tissue inhibitor (TIMP-2) transforming growth factor beta 1 (TGF-β1) aqueous humor serum samples patients with pseudoexfoliation (PEX) syndrome.Aqueous were collected from 32 PEX syndrome (with without glaucoma) a control group, who underwent routine cataract surgery. Levels MMP-2, TIMP-2, TGF-β1 determined by specific immunoassays (enzyme-linked...

To evaluate changes in the thickness of central macula, macular ganglion cell-inner plexiform layer (mGCIPL), and subfoveal choroid patients with psoriasis using spectral domain optical coherence tomography (SD-OCT).The measurements macular, mGCIPL thicknesses choroidal (SFCT) obtained by SD-OCT (n = 46). These were compared those 50 healthy controls.The mGCIPL, did not differ between controls psoriatic subjects (p>0.05). When divided into two distinct groups, only SFCT was significantly...

The aim of this study was to compare the frequency occurrence obesity and high risk developing obstructive sleep apnea (OSA) in a keratoconus population with that control group.This prospective, case-controlled multicenter performed on patients age- gender-matched subjects. One hundred forty-six were included each group, Berlin Questionnaire used for classifying as having or low OSA. patients' demographic clinical characteristics compared Mann-Whitney U test continuous variables χ...

Objective: Dexmedetomidine is an alpha 2 adrenoceptor agonist and can be used for postoperative sedation, analgesia anesthesia-sparing properties. Furthermore, the neuroprotective effects against ischemia/reperfusion (I/R) injury in central nervous system have been shown experimental studies. This study aimed to investigate protective of dexmedetomidine apoptosis retinal I/R rat.Materials methods: Retinal was induced by transient elevation intraocular pressure. Eighteen animals were divided...

To investigate the effect of chronic cigarette smoking on endothelial cells cornea via non-contact specular microscopy.In this prospective, cross-sectional study, 25 eyes smokers and 21 age-matched, healthy non-smokers were enrolled. The Fagerström Test for Nicotine Dependence Cigarettes was used to determine nicotine dependency level. level cotinine, a major metabolite nicotine, measured in urine samples from control group detect whether they passively affected by smoke. All participants...

Purpose: To compare the subfoveal choroidal thickness (SFCT) of patients with different severities obstructive sleep apnea/hypopnea syndrome (OSAHS) and normal controls via enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: In this retrospective, case-control study, 49 eyes from that had undergone polysomnography were included. SFCT horizontal vertical line scans manually measured for all based on EDI-OCT images. Two separate analyses performed according to index (AHI)...

To evaluate structural alterations of iris and pupil diameters (PDs) in patients using systemic α-1-adrenergic receptor antagonists (α-1ARAs), which are associated with intraoperative floppy syndrome (IFIS).Eighty-eight eyes 49 male were evaluated prospectively. Patients assigned to 2 different groups. Study group included 23 taking any α-1ARAs treatment, control 26 not treatment. All underwent anterior segment optical coherence tomography thickness at the dilator muscle region (DMR)...

Purpose. To describe a surgical technique using amniotic membrane transplant (AMT) with fibrin glue (FG) for treating smaller corneal perforations more practically and appropriately filling the defect. Method. A patient noninfectious central perforation, in 1 mm diameter, was treated FG-assisted AMT-plug. An AMT folded on itself twice by FG then small piece of this FG-AMT mixture cut to maintain an appropriate plug site perforation. The AMT-plug placed perforation area FG. patch over plug,...

Purpose: To analyze the intrasession and intersession repeatability of contrast sensitivity (CS) measurements in patients with glaucoma, cataract, or age-related macular degeneration (AMD) healthy controls. Methods: CS were performed using OPTEC-Functional Vision Analyzer (FVA), which uses a standardized closed (view-in) system. Measurements for AMD controls repeated within 30 minutes (intrasession) during two sessions (intersession), separated by one week to month. Test-retest reliability...

Purpose To find out the relationship between steroid-induced intraocular pressure (IOP) rise and plasma levels of matrix metalloproteinase-9 (MMP-9) tissue inhibitor MMP-2 (TIMP-2) in diabetic patients who underwent intravitreal triamcinolone acetonide (IVTA) injection for treatment macular edema. Subjects Methods A total 34 with edema were treated IVTA 17 healthy subjects served as control group MMP TIMP participated. Before treatment, complete ophthalmologic examination, including...

Purpose: To compare the contamination rate between 27-gauge and 30-guage needles used for intravitreal injection (IVT).Methods: Patients undergoing IVT injections were enrolled prospectively. Injections performed with 27- or 30-gauge needles. All needle tips collected placed in brain–heart infusion broth. The rates of compared.Results: A total 109 patients participated study a 126 performed. by (49%) (51%) needle. No patient developed endophthalmitis. overall 13% 27-guage 29% (p = 0.022)....

The aim of this study was to report a patient who developed full-thickness macular hole following intravitreal bevacizumab injection.A 78-year-old diagnosed with choroidal neovascularisation (CNV) treated injection.On the first follow-up visit, decrease in visual acuity seen and small complete resolution subretinal fluid observed optical coherence tomography (OCT). A second injection performed. At subsequent serious loss limited regression seen. OCT showed larger hole.This case demonstrates...

The aim was to evaluate the corneal and bulbar conjunctival thicknesses of soft contact lens (SCL) wearers using anterior segment optical coherence tomography (AS-OCT).The epithelial overall both central cornea infero-temporal conjunctiva SCL (30 subjects) were obtained by Cirrus HD-OCT compared with those refraction-matched controls patients emmetropia subjects).The mean in wearing, spectacle-wearing emmetropic groups 48.97 ± 5.45, 52.18 4.84 53.18 5.05 µm, respectively. epithelium members...

Purpose: To investigate the preventive effects of topical sunitinib, sunitinib-hesperetin and sunitinib-doxycycline combinations on corneal neovascularization (CNV), apoptosis fibrosis in a alkali burn model. Materials Methods: The corneas 32 Wistar albino rats were cauterized with silver nitrate to induce CNV. Four groups created receiving artificial tears (sham), sunitinib (0.5 mg/ml), mg/ml-0.2 mg/ml-20 mg/ml) treatments. Corneal photographs taken days 0, 7 15‎. Photographs cornea...

Purpose: The contrast sensitivity (CS) function in patients with primary Sjögren's syndrome (pSS) may be impaired either frequently as a result of dry eye diseases or rarely optic neuropathy. In this study, we aimed to evaluate the CS pSS well assess corneal aberrations and thickness peripapillary retinal nerve fiber layer (pRNFL). Methods: Fourteen eyes 14 (pSS group) healthy participants (control were subjected assessment at spatial frequencies 1.5, 3.0, 6.0, 12, 18 cycles/degree (cpd)...

To evaluate the effects of Ramadan fasting on central foveal thickness (CFT) and subfoveal choroidal (SFCT) in healthy individuals using enhanced depth imaging optical coherence tomography (EDI-OCT).The EDI-OCT scans 42 obtained after about 12 hours at least twenty-first consecutive day were compared to same patients taken one month last they had fasted.CFT values similar for both time periods (p > 0.05). The SFCT was significantly higher days towards end Ramadan, no (one ended) <...

To evaluate the ocular penetration of daptomycin, a new antibiotic agent targeted against Gram-positive organisms.Thirty-two New Zealand white rabbits were divided into 4 equal groups. One drop 50 μL 1% daptomycin was administered to group 1. In 2, 1 after corneal epithelium scraped. 3, every 15 min for h (keratitis protocol). 4, keratitis protocol applied groups and aqueous humor samples collected 30 min, h, 2 single under general anesthesia. All animals in 3 humanely killed. Cornea, humor,...