A5040789885- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Tea Polyphenols and Effects
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Medicinal Plants and Neuroprotection
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Vitamin C and Antioxidants Research
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Vitamin K Research Studies
- Synthesis of Organic Compounds
- Chromatography in Natural Products
- Essential Oils and Antimicrobial Activity
- Genomics, phytochemicals, and oxidative stress
- Natural Antidiabetic Agents Studies
- Enzyme function and inhibition
- Effects and risks of endocrine disrupting chemicals
- SARS-CoV-2 and COVID-19 Research
- Health, Environment, Cognitive Aging
- Advances in Cucurbitaceae Research
- Potato Plant Research
- Cancer therapeutics and mechanisms
- Birth, Development, and Health
University of the Punjab
2020-2024
Nanjing University of Chinese Medicine
2022
Liaquat University of Medical & Health Sciences
2019
Cancer is the second leading cause of death worldwide. Uncontrolled proliferation cells a hallmark cancer development and progression. Ki-67 (a marker Kiel-67) Proliferating Cell Nuclear Antigen (PCNA) are two major proliferations, diagnostic prognostic biomarkers as these over expressed in cancerous cells. Pharmacological inhibition PCNA could effectively inhibit growth Objective: To identify Sesquiterpene Lactones (SLs) potential inhibitors to reduce burden. Methods: The inhibitory SLs,...
Cancer is second most common cause of death globally. Uncontrolled regulation cell cycle may various cancerous anomalies. Objective: To Identify Sesquiterpene Lactones (SLs) as inhibitors Cyclin B1 (CB1) and Dependent Kinase 1 (CDK1) complex. Methods: Checkpoints proteins (CDK1/CB1) G2/M phase have been assessed with three SLs (ilicol, eucalyptone ascleposide E) through molecular docking study. AutoDock Vina (ADV), PyMol version-2.5.2 BIOVIA Discovery Studio 2021 was used for the...
Cancer is a mechanistically complex and diverse disease with plethora of fundamental genetic epigenetic factors. Signal transducer activator transcription-3 (STAT3) transcription factor, its constitutive activation executes promotion cellular proliferation, cell cycle, angiogenesis, metastasis, immunosuppression, chemo-resistance in cancer cells. Here, we aimed to design natural potential STAT3 inhibitors. For this purpose, investigated 92 phytochemical compounds by molecular docking studies...
Bisphenol A (BPA) that is a monomer of plastic products may possibly interfere with epigenetics and be involved in onset progression several diseases. This study was aimed to detect the epigenetic effects utero BPA exposure mice offspring.All experiments were performed according national guidelines for laboratory animals after ethical approval. Thirty adult BALB/c female divided into 3 equal groups, G1 (controls), G2 (ethanol 0.10 ml/100ml PBS so final concentration would 0.01%) vehicle...
Cancer is a major health problem and second foremost cause of death globally.Chemotherapy either targeted or non-targeted pervasive in the treatment cancer but due to continuous repeated doses, cells develop resistance against these chemotherapeutic drugs through multiple mechanisms including MDR1 gene expression.EGCG (Epigallocatechin-3-Gallate) one polyphenols present dry leaves green tea plant (Camellia sinensis).It has been observed potentiate apoptosis also inhibit cell growth by...
Centipeda minima (C. minima), is a medicinally important herb commonly called "Sneeze Weed" and widely distributed in humid areas. In China, Malaysia, Nepal, it used folk medicines for the treatment of rhinitis, nasopharyngeal carcinoma, respiratory disorders, also exhibits antibacterial, antioxidant antiprotozoal activity. Recently discovered that various bioactive molecule C. has strong potential to be neoplasms. Thus, this review, we aim summarize discuss cellular targets anticancer...
The novel strain of coronavirus, SARS-CoV-2, has spread adverse effects on human health with high mortality rates worldwide. SARS-CoV-2 is a severe respiratory disease expressed through positive single stranded RNA enveloped virus. had affected globally and influencing the economy as well. rapidly spreading coronavirus infection discombobulated researchers in perpetuate search for different or effective therapeutic drugs. Most connatural products are proposed to have significant clinical...