A5034095797- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Hernia repair and management
- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Pancreatic function and diabetes
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Gene expression and cancer classification
- Photochromic and Fluorescence Chemistry
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Molecular Biology Techniques and Applications
- Telomeres, Telomerase, and Senescence
- Lung Cancer Research Studies
- Single-cell and spatial transcriptomics
- DNA Repair Mechanisms
- Medical and Biological Ozone Research
University College London
2021-2025
CRUK Lung Cancer Centre of Excellence
2023
University of Southampton
2023
University Hospital Southampton NHS Foundation Trust
2021
University of Leicester
2020
Congenital diaphragmatic hernia (CDH) results in lung hypoplasia. In severe cases, tracheal occlusion (TO) can be offered to promote growth. However the benefit is limited, and novel treatments are required supplement TO. Vascular endothelial growth factor (VEGF) downregulated animal models of CDH could a therapeutic target, but its role human not known. To investigate whether VEGF supplementation suitable treatment for CDH-associated pathology. Fetal lungs from patients were used determine...
Preinvasive squamous lung lesions are precursors of cell carcinoma (LUSC). The cellular events underlying lesion formation unknown. Using a carcinogen-induced model LUSC with no added genetic hits or type bias, we find that carcinogen exposure leads to non-neutral competition among basal cells, aberrant clonal expansions, and mobilization along the airways. Ultimately, preinvasive develop from few highly mutated clones dominate most bronchial tree. Multi-site sequencing in human patients...
Background Silver-Russell syndrome (SRS) is an imprinting disorder characterised by prenatal and postnatal growth restriction, but its clinical features are non-specific differential diagnosis broad. Known molecular causes of SRS include disturbance, single nucleotide variant (SNV), CNV or UPD affecting several genes; however, up to 40% individuals with a currently receive no positive diagnosis. Methods To determine whether whole-genome sequencing (WGS) could uncover pathogenic variants...
Abstract Rationale Congenital diaphragmatic hernia (CDH) results in lung hypoplasia. In severe cases, tracheal occlusion (TO) can be offered to promote growth. However the benefit is limited, and novel treatments are required supplement TO. Vascular endothelial growth factor (VEGF) downregulated animal models of CDH could a therapeutic target, but its role human not known. Objectives To investigate whether VEGF supplementation suitable treatment for CDH-associated pathology. Methods Fetal...
The alternative lengthening of telomeres (ALT) facilitates telomere by a DNA strand invasion and copying mechanism. nuclear receptors (NRs), NR2F2 NR2C2, can bind to (TCAGGG)n variant repeats within it has been proposed that this interactions in ALT+ cells. Here we show the frequency cells with detectable NR2C2 foci varies considerably between cell lines does not correlate level protein expression. In addition, four five lack some telomeres, indicating direct NR binding play role ALT at...
Background Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of cancer deaths worldwide, and is preceded by the appearance progressively disorganised pre-invasive lesions in airway epithelium. Yet biological mechanisms underlying progression into invasive LUSC are not fully understood. LRIG1 (leucine-rich repeats immunoglobulin-like domains 1) downregulated tumours this correlates with decreased lung patient survival. Methods results Using an Lrig1 knock-in reporter...
Abstract PLAGL1 is one of a group imprinted genes, whose altered expression causes imprinting disorders impacting growth, development, metabolism, and behavior. over‐expression transient neonatal diabetes mellitus (TNDM type 1) and, based on murine models, under‐expression would be expected to cause growth restriction. However, only some reported individuals with upd(6)mat have restriction, giving rise uncertainty about the role in human growth. Here we report three investigated for two...
<h3>Background</h3> Advanced lung cancer kills 90% of patients within a decade, underscoring an urgent need for improved early detection and prevention technologies. T cell responses are initiated dysregulated during carcinogenesis <i>in vivo</i>, providing potential basis immune-focused interception. Here we examined cross-tissue dynamics human murine squamous to assess their utility in immune-interception. <h3>Methods</h3> Over decade ago clinical autofluorescence bronchoscopy surveillance...
Abstract Lung carcinoma in situ (CIS) lesions, as precursors to squamous cell carcinoma, exhibit microscopic uniformity while displaying diverse clinical trajectories. Half of these lesions progress invasive cancer, the remaining half either regress or remain indolent. Previous genomic profiling efforts have elucidated progression-specific changes against a backdrop inherent heterogeneity and notable chromosomal instability signatures. Here, we present novel approach by analyzing...
<h3>Background</h3> The majority of respiratory symptoms and radiological abnormalities post-COVID-19 improve. However, residual changes are observed in approximately 10% symptomatic patients at 12 months post-hospitalization. aim this study was to further our understanding the immunopathomechanisms associated with persistence resolution post-COVID interstitial lung disease (ILD), order facilitate early therapeutic intervention accelerate recovery minimize potentially irreversible damage....