A5074735389- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Mass Spectrometry Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Adsorption, diffusion, and thermodynamic properties of materials
- Surfactants and Colloidal Systems
- Chromatography in Natural Products
- Supramolecular Self-Assembly in Materials
- Enzyme Structure and Function
- Computational Drug Discovery Methods
- Molecular Junctions and Nanostructures
- Alzheimer's disease research and treatments
- Microfluidic and Capillary Electrophoresis Applications
- Advancements in Transdermal Drug Delivery
- nanoparticles nucleation surface interactions
- Polymer crystallization and properties
- SARS-CoV-2 and COVID-19 Research
- Analytical Chemistry and Sensors
- Geomagnetism and Paleomagnetism Studies
- Chemical Thermodynamics and Molecular Structure
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Organic Electronics and Photovoltaics
- Natural product bioactivities and synthesis
Marche Polytechnic University
2017-2025
University of Genoa
1999-2020
Industriale Chimica (Italy)
1994
Lipid nanoparticles own a remarkable potential in nanomedicine, only partially disclosed. While the clinical use of liposomes and cationic lipid-nucleic acid complexes is well-established, liquid lipid (nanoemulsions), solid nanoparticles, nanostructured carriers have even greater possibilities. However, they face obstacles being used clinics due to lack understanding about molecular mechanisms controlling their drug loading release, interactions with biological environment (such as protein...
The main protease (Mpro or 3CLpro) is an enzyme that evolutionarily conserved among different genera of coronaviruses. As it essential for processing and maturing viral polyproteins, Mpro has been identified as a promising target the development broad-spectrum drugs against Like SARS-CoV MERS-CoV, mature active form SARS-CoV-2 dimer composed identical subunits, each with single site. Individual monomers, however, have very low no catalytic activity. such, inhibition can be achieved by...
We propose a novel method for determining the structural and thermodynamic properties of nanoparticle-protein complexes under physiological conditions. The consists collecting full set small-angle X-ray neutron-scattering measurements in solutions with different concentrations nanoparticles protein. dissociation process is described framework Hill cooperative model, based on which whole data fitted simultaneously. This applied to water gold presence human serum albumin without any previous...
The mixing of Guanosine (Gua) and 5'-monophosphate (GMP) in water selected compositions yields highly hydrated, transparent, self-healing self-assembled supramolecular G-hydrogels, attractive for biomedical applications. This work investigates how hydrogel composition affects solute transport, including diffusion, binding, loading, release properties, using a set fluorescent probes with varying size polarity. Although small/wide-angle X-ray scattering techniques showed that no structural...
Diatoms represent the most abundant and diversified class of primary producers in present oceans; their distinctive trait is ability to incorporate silicic acid a silica outer shell called frustule. Numerous adaptative functions are ascribed frustules, including control vertical movements through water column; this indirectly determines cell access fundamental resources such as light nutrients, favors diatom escape from predators. At same time, guides phototroph column by affecting density...
α-Sexithiophene (T6) thin films become smooth and featureless when annealed at temperatures above 160°C. (The Figure shows a typical film before (left) after (right) being for 20 min 170°C.) This change in morphology is characterized terms of the roughness exponent it suggested that threshold temperature represents onset fast diffusion T6 molecules on surface
An approach for reducing toxicity and enhancing therapeutic potential of supramolecular polyamine phosphate nanoparticles (PANs) through PEGylation polyamines before their assembly into is presented here. It shown that the number polyethylene glycol (PEG) chains largely influence physico-chemical properties PANs biological endpoints. Poly(allylamine hydrochloride) (PAH) are functionalized carbodiimide chemistry with three ratios PEG molecules per PAH chain: 0.1, 1, 10. PEGylated then...
The kinetics of ε-caprolactam fast-activated anionic polymerization in the bulk under quasi-adiabatic conditions is analyzed terms three semiempirical schemes. Malkin's model, most frequently quoted approach literature, provides an excellent simulation our experimental conditions, but values derived parameters do not remain constant, as predicted by model when different are chosen, and allow any correlation with physical chemical aspects reaction. same limit exists for Lin's a poorer...
Taurine is an important organic osmolyte in mammalian cells, and it weakens inflammation oxidative stress mediated injuries some diseases. Recently, taurine has been demonstrated to play a therapeutic role against neurodegenerative disorders, although its parallel involvement several biochemical mechanisms makes not clear specific these Furthermore, the stabilizing effect of this molecule terms protein stability known, but deeply investigated. In work we explore by Circular Dichroism impact...