A5021735088- Osteoarthritis Treatment and Mechanisms
- Cystic Fibrosis Research Advances
- Musculoskeletal synovial abnormalities and treatments
- Shoulder Injury and Treatment
- Sinusitis and nasal conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Atomic and Subatomic Physics Research
- Head and Neck Surgical Oncology
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Shoulder and Clavicle Injuries
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Advanced MRI Techniques and Applications
- Lower Extremity Biomechanics and Pathologies
- Nuclear Physics and Applications
- Pediatric health and respiratory diseases
- Congenital Ear and Nasal Anomalies
- Pneumonia and Respiratory Infections
- Foot and Ankle Surgery
- Nerve Injury and Rehabilitation
- Tendon Structure and Treatment
University Hospital Heidelberg
2017-2025
Heidelberg University
2017-2025
German Center for Lung Research
2018-2025
Helios Dr. Horst Schmidt Kliniken Wiesbaden
2022-2024
Society of Interventional Radiology
2024
Introduction: Previous studies using magnetic resonance imaging (MRI) demonstrated early onset and progression of chronic rhinosinusitis (CRS) from infancy to school age, response lumacaftor/ivacaftor (LUM/IVA) therapy in children with cystic fibrosis (CF). However, the effect elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on CRS detected by MRI CF at least one F508del mutation, potential incremental effects ELX/TEZ/IVA compared LUM/IVA homozygous have not been studied.Methods: 30 mutation...
Rationale: Chronic rhinosinusitis (CRS) contributes to disease burden of patients with cystic fibrosis (CF). However, its onset and progression in infants preschool children CF remain poorly understood.Objectives: To determine the prevalence extent CRS young using magnetic resonance imaging (MRI).Methods: MRI was performed sedation 67 (mean age 2.3 ± 2.1 yr; range 0–6 yr) 30 non-CF control subjects (3.5 2.0 yr). Paranasal sinus dimensions structural abnormalities, including mucosal swelling;...
Rationale: Chronic rhinosinusitis (CRS) contributes to morbidity in patients with cystic fibrosis (CF). However, longitudinal data on CRS onset and progression is lacking. Objectives: To longitudinally evaluate CF from infancy school age paranasal sinus magnetic resonance imaging (MRI). Methods: A total of 64 children (mean at baseline, 1.1 ± 1.6 yr; range, 0-5 yr) underwent a mean 5.8 2.2 (range, 3-11 subsequent annual MRI examinations. Additional 24 (9.2 4.4 3-17 homozygous for the F508del...
Abstract Objectives We hypothesized that semiquantitative visual scoring of lung MRI is suitable for GOLD-grade specific characterization parenchymal and airway disease in COPD scores correlate with quantitative CT (QCT) pulmonary function test (PFT) parameters. Methods Five hundred ninety-eight subjects from the COSYCONET study (median age = 67 (60–72)) at risk or GOLD1-4 underwent PFT, same-day paired inspiratory/expiratory CT, structural contrast-enhanced MRI. QCT assessed total volume...
Introduction In children with pneumonia, chest x-ray (CXR) is typically the first imaging modality used for diagnostic work-up. Repeated CXR or computed tomography (CT) are often necessary if complications such as abscesses empyema arise, thus increasing radiation exposure. The aim of this retrospective study was to evaluate potential radiation-free magnetic resonance (MRI) detect at baseline and follow-up, compared without additional lung ultrasound (LUS). Methods Paired MRI scans were...
Rationale: Primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) are characterized by inherited impaired mucociliary clearance leading to chronic progressive lung disease as well rhinosinusitis (CRS). The diseases share morphological functional commonalities on magnetic resonance imaging (MRI) of the lungs paranasal sinuses, but comparative MRI studies lacking. Objectives: To determine whether PCD shows different associations pulmonary sinus abnormalities function test results in...
Introduction: Chronic rhinosinusitis (CRS) usually presents with nasal congestion, rhinorrhea and anosmia impacts quality of life in cystic fibrosis (CF). Especially mucopyoceles pathognomonic for CRS CF may cause complications such as spread infection. Previous studies using magnetic resonance imaging (MRI) demonstrated early onset progression from infancy to school age patients CF, mid-term improvements preschool school-age children treated lumacaftor/ivacaftor at least 2 months. However,...
In-line free propagation phase-contrast synchrotron tomography of the lungs has been shown to provide superior image quality compared with attenuation-based computed (CT) in small-animal studies. The present study was performed prove applicability on a human-patient scale using chest phantom ventilated fresh porcine lungs. Local areas interest were imaged pixel size 100 µm, yielding high-resolution depiction anatomical hallmarks healthy and artificial lung nodules. Details like fine...
Purpose To evaluate the utility of delayed gadolinium‐enhanced magnetic resonance imaging cartilage (dGEMRIC) and T 2 mapping in evaluation type II osteochondral lesions (OCLs) talus define cutoff values for identifying patients with good/poor clinical outcomes. Materials Methods 28 (mean age, 42.3 years) underwent dGEMRIC at least 1.5 years duration, 3.5 after microfracture ( n = 12) or conservative 16) treatment OCL. Clinical outcomes were considered good an American Orthopedic Foot Ankle...
Abstract This study evaluated the ability of T2 mapping to assess glenoid cartilage using arthroscopy as gold standard. Eighteen consecutive patients (mean age: 52.4 ± 14.72 years, including 12 men) with shoulder pain underwent at 3-T subsequent arthroscopy. With correlation cartilage-sensitive morphologic sequences regions-of-interest were placed in corresponding maps both normal-appearing and focal lesions a quadrant-wise approach. Inter-reader intra-reader coefficients (ICCs) between two...
This study investigated the ability of T2 mapping to assess glenoid labrum and differentiate between healthy labral substances superior anterior posterior (SLAP) lesions using arthroscopy as gold standard. Eighteen patients (mean age: 52.4 ± 14.72 years, 12 men) with shoulder pain were examined 3-Tesla mapping. All underwent arthroscopy. Using morphological sequences for correlation, regions interest covering entire substance placed in corresponding maps. The diagnostic cutoff values,...
The aim of this study was to apply quantitative computed tomography (QCT) for GOLD-grade specific disease characterization and phenotyping air-trapping, emphysema, airway abnormalities in patients with chronic obstructive pulmonary (COPD) from a nationwide cohort study.
Background We sought to replace full‐dose Gd‐DTPA with safer and lower‐dose contrast agents for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC). Gd‐BOPTA has a lower intrinsic nephrogenic systemic fibrosis risk 2‐fold higher relaxivity at 3T; thus, the agent dose may be halved, further reducing agent‐dependent risks. Purpose To compare feasibility using half‐dose, high‐relaxivity vs. standard‐dose dGEMRIC. Study Type Prospective observational study. Subjects Eleven healthy volunteers...
Abstract Background Superior labral anterior to posterior (SLAP) lesions remain a clinical and diagnostic challenge in routine (non-arthrographic) MR examinations of the shoulder. This study prospectively evaluated ability 3D-Multi-Echo-Data-Image-Combination (MEDIC) compared that high resolution 2D-proton-density weighted fat-saturated (PD fs) sequence using 3 T-MRI detect SLAP arthroscopy as gold standard. Methods Seventeen consecutive patients (mean age, 51.6 ± 14.8 years, 11 males) with...
Purpose: To explore the typical magnetic resonance imaging (MRI) pattern of osteoblastoma (OB) after radiofrequency ablation (RFA) treatment and to identify signs indicating success or relapse.Materials methods: Forty-four follow-up MRI examinations 15 patients with OB who had undergone 19 RFA procedures were analyzed retrospectively. An early group (1-4 months RFA) a late (8-131 established. The groups further subdivided according success. Images for presence central nidus enhancement...
Introduction Quantitative analysis of multi-detector computed tomography (MDCT) plays an increasingly important role in assessing airway disease. Depending on the algorithms used, dimensions may be over- or underestimated, primarily if contrast material was used. Therefore, we tested a modified integral-based method (IBM) to address this problem. Methods Temporally resolved cine-MDCT performed seven ventilated pigs breath-hold during iodinated (CM) infusion over 60s. Identical slices...
This study evaluates how far T2 mapping can identify arthroscopically confirmed pathologies in the long biceps tendon (LBT) and quantify values healthy pathological substance. comprised eighteen patients experiencing serious shoulder discomfort, all of whom underwent magnetic resonance imaging, including sequences, followed by joint arthroscopy. Regions interest were meticulously positioned on their respective maps, capturing sulcal portion LBT allowing for quantification average values....
Juvenile Osteochondritis Dissecans (JOCD) is a common reason for knee pain among children. The aim of this case study was to report on clinical and radiographic outcomes after fixation an osteochondral fragment with bioabsorbable pins in children open growth plates. We hypothesized that surgical treatment technique will result good function, high rates healing return sport rates. A total 13 knees 12 patients (6 male, 6 female) median years (11, 17) were evaluated retrospectively at minimum...