A5027769926- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Infectious Diseases and Mycology
- Single-cell and spatial transcriptomics
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Machine Learning in Healthcare
- Pharmaceutical studies and practices
- Bacteriophages and microbial interactions
- Artificial Intelligence in Healthcare
- Thermoregulation and physiological responses
- Physical Education and Training Studies
- Human Health and Disease
- Bacillus and Francisella bacterial research
- Biotin and Related Studies
- Immune responses and vaccinations
- Viral Infections and Outbreaks Research
- Extracellular vesicles in disease
- COVID-19 diagnosis using AI
- Sperm and Testicular Function
- Metal and Thin Film Mechanics
- Cancer Genomics and Diagnostics
- Cell Image Analysis Techniques
- Healthcare Systems and Public Health
- Biochemical effects in animals
Helmholtz Zentrum München
2023-2025
German Center for Lung Research
2023-2025
Dermatology Research Center
2025
Technical University of Munich
2024
Hudson Institute
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Agency for Science, Technology and Research
2021-2022
Bioinformatics Institute
2021-2022
Siberian State Medical University
2019
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms and fibrogenesis directly in human tissue has been hampered by the lack organotypic models analytical techniques. In this work, we coupled ex vivo cytokine drug perturbations precision-cut lung slices (hPCLS) with single-cell RNA sequencing induced multilineage circuit fibrogenic cell states hPCLS. We showed that these were highly similar to multicohort atlas from patients pulmonary...
Escherichia coli (E. coli) has been one of the most studied model organisms in history life sciences. Initially thought just to be commensal bacteria, E. shown wide phenotypic diversity including pathogenic isolates with great relevance public health. Though pangenome analysis attempted several times, there is no systematic functional characterization subgroups according gene profile.Systematically scanning for optimal parametrization, we have built from 1324 complete genomes. The size...
Abstract With progressive digitalization of healthcare systems worldwide, large-scale collection electronic health records (EHRs) has become commonplace. However, an extensible framework for comprehensive exploratory analysis that accounts data heterogeneity is missing. Here we introduce ehrapy, a modular open-source Python designed heterogeneous epidemiology and EHR data. ehrapy incorporates series analytical steps, from extraction quality control to the generation low-dimensional...
Abstract Background The human proteins TMTC1, TMTC2, TMTC3 and TMTC4 have been experimentally shown to be components of a new O-mannosylation pathway. Their own mannosyl-transferase activity has suspected but their actual enzymatic potential not demonstrated yet. So far, sequence analysis TMTCs compromised by evolutionary divergence within membrane-embedded N-terminal region, inaccuracies in the protein databases difficulty interpret large functional variety known homologous (mostly sugar...
ABSTRACT Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms and fibrogenesis directly in human tissue has been hampered by the lack organotypic models analytical techniques. In this work, we coupled ex vivo cytokine drug perturbations precision-cut lung slices (hPCLS) with scRNAseq induced multi-lineage circuit fibrogenic cell states hPCLS, which show to be highly similar multi-cohort atlas from pulmonary patients. Using micro-CT staged...
Abstract Biphasic insulin aspart 30 is a premixed formulation containing soluble fraction of (30%) and protamine‐crystallized (70%) that was developed to combine the rapid‐acting prolonged advantages commercially available insulins. The aim this bioequivalence study compare pharmacokinetics (PKs) GP‐bi‐asp Novo‐bi‐asp, evaluate pharmacodynamic (PD) properties as well safety these drugs in hyperinsulinemic euglycemic clamp (HEC) procedure. This phase 1, randomized, double‐blind, 2‐sequence,...
РАСПРОСТРАНЕННОСТЬ ФАКТОРОВ РИСКА ХРОНИЧЕСКИХ НЕИНФЕКЦИОННЫХ ЗАБОЛЕВАНИЙ СРЕДИ СТУДЕНТОВ-ПЕРВОКУРСНИКОВ ГОРОДА ТОМСКА
Pulmonary fibrosis (PF) is the shared central pathomechanism across multiple entities of interstitial lung diseases. Studying mechanisms regeneration and fibrogenesis directly in human tissue has been hampered by lack organotypic models analytical techniques. Here, we coupled <i>ex vivo</i> cytokine drug perturbations precision-cut slices (hPCLS) with single-cell RNA sequencing to study early tissue. Comparing hPCLS perturbation data against an <i>in multi-cohort atlas from PF patients...
Abstract With progressive digitalization of healthcare systems worldwide, large-scale collection electronic health records (EHRs) has become commonplace. However, an extensible framework for comprehensive exploratory analysis that accounts data heterogeneity is missing. Here, we introduce ehrapy, a modular open-source Python designed end-to-end heterogeneous epidemiology and record data. Ehrapy incorporates series analytical steps, from extraction quality control to the generation...
мЕТОДИЧЕСКИЙ пОДХОД К АНАЛИЗУ ВЕЩЕСТВ, СОДЕРЖАЩИХ В СТРУКТУРЕ
ВЛИЯНИЕ ИНТЕРЛЕЙКИНОВ il-1α
The blood concentrations of cortisol, aldosterone, thyroxine, triiodothyronine were studied in adult dogs and 3-month puppies every 2 hours during 32 hours. circadian variation these hormones was shown to differ the mean daily level, amplitude variations, time acrophases two age groups animals. findings suggest that diurnal chronotype changes with