A5048813998- Microplastics and Plastic Pollution
- Diabetes Treatment and Management
- Effects and risks of endocrine disrupting chemicals
- Click Chemistry and Applications
- Graphene and Nanomaterials Applications
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Birth, Development, and Health
- Neuropeptides and Animal Physiology
- Aquaculture Nutrition and Growth
- Receptor Mechanisms and Signaling
- Zebrafish Biomedical Research Applications
- Environmental Toxicology and Ecotoxicology
- biodegradable polymer synthesis and properties
- Per- and polyfluoroalkyl substances research
- Healthcare cost, quality, practices
- Pesticide Exposure and Toxicity
- Nitric Oxide and Endothelin Effects
- Vitamin D Research Studies
- Synthesis and Biological Evaluation
- Marine Biology and Environmental Chemistry
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Neuroinflammation and Neurodegeneration Mechanisms
Banaras Hindu University
2011-2025
Indian Institute of Technology Bombay
2024
Institute of Medical Sciences
2022
All India Institute of Medical Sciences
2022
XLAB (Slovenia)
2021
Cypermethrin (CYP), a synthetic type II pyrethroid pesticide, is extensively used to control pests in industrial, domestic, and agricultural environments. However, its indiscriminate use leads potential threat aquatic organisms. Although several reports focussed on developmental toxicity effects, concise study combining cardiotoxicity along with Na+/K+-ATPase activity molecular docking of proteins CYP was lacking. This present designed address this gap comprehend the impact exposure (0, 25,...
This article describes studies on the design, synthesis, and biological evaluation of pyrazole-containing β-amino carbonyl compounds (5a-5q) as DPP-4 inhibitors anti-diabetic agents. In contrast, mannich reactions went smoothly with bismuth nitrate (Bi (NO3 )3 ) catalyst in presence ethanol produced good yield. Molecular docking designed derivatives enzyme (PDB: 2OLE), 5d, 5h, 5j, 5k showed excellent interaction. 3D QSAR pharmacophoric model were also carried out. ADMET parameters,...
Stroke is the second largest cause of mortality (WHO 2014) and long-lasting disability worldwide. Many risk factors are associated with stroke, such as age, gender, chronic illnesses, cardiovascular disease, lifestyle, smoking. With global industrialization, roles environmental contaminants their association stroke still unclear have attracted much more attention.We conducted a systematic review on toxic metal ischemic stroke. A comprehensive literature search was carried out till June 30,...
Perfluorooctanesulfonic acid (PFOS) is a prevalent, persistent organic pollutant in environmental matrices, yet its precise mechanism of neurotoxicity remains unclear. This study investigated the developmental and neurobehavioral effects PFOS exposure (0, 100, 500, 1000 µg/L) on zebrafish. The findings indicated that caused various abnormalities, including increased mortality, delayed hatching, shortened body length, bent spine, edema pericardial yolk sac regions. Subsequently, larvae...
In this study, we aimed to elucidate the possible harmful effects of polystyrene microplastics (PS-MPs) on female reproduction via SIRT1 modulation. Female zebrafish were exposed different concentrations (50 and 500 µg/L) PS-MPs. The results revealed a significant reduction in gonadosomatic index after exposure addition, decreased fecundity rate displayed an evident dosage effect, indicating that PS-MPs causes deleterious fertilization. Furthermore, significantly enhanced levels reactive...
Abstract Background Stroke is the second largest cause of mortality (WHO 2014) and long-lasting disability worldwide. Many risk factors are associated with stroke: age, gender, chronic illnesses, cardiovascular disease, lifestyle, smoking. With global industrialisation, roles environmental contaminants their association stroke still unclear have attracted much more attention. Methodology We conducted a systematic review on toxic metals ischemic stroke. A comprehensive literature search was...
A series of novel pyridazine-acetohydrazide hybrids were designed, synthesized, and evaluated for their in vitro vivo antihyperglycemic activity. In this context pyridazine-acetohydrazides (6a-6p) synthesized by coupling substituted aldehyde with 2-(5-cyano-6-oxo-3,4-diphenylpyridazine-1-6H-yl) acetohydrazide, which was prepared via the reaction pyridazine ester hydrazine hydrate. The molecular modeling study carried out to examine binding affinities interaction designed compounds against...