A5016182893- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Redox biology and oxidative stress
- Fluorine in Organic Chemistry
- Smoking Behavior and Cessation
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Molecular Sensors and Ion Detection
- Antioxidant Activity and Oxidative Stress
- Organic Chemistry Cycloaddition Reactions
- Electron Spin Resonance Studies
- Oxidative Organic Chemistry Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced Chemical Sensor Technologies
- Click Chemistry and Applications
- Genomics, phytochemicals, and oxidative stress
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chemical Reactions and Mechanisms
- Alcohol Consumption and Health Effects
Centers for Disease Control and Prevention
2019-2021
National Center for Environmental Health
2019-2021
Center for Environmental Health
2020
Oak Ridge Associated Universities
2019
Oak Ridge Institute for Science and Education
2019
Georgia State University
2015-2017
Gwinnett College
2015
The causative agents for the current national outbreak of electronic-cigarette, or vaping, product use-associated lung injury (EVALI) have not been established. Detection toxicants in bronchoalveolar-lavage (BAL) fluid from patients with EVALI can provide direct information on exposure within lung.BAL fluids were collected 51 16 states and 99 healthy participants who part an ongoing study smoking involving nonsmokers, exclusive users e-cigarettes vaping products, cigarette smokers that was...
Abstract Pyrazoles are highly essential heterocyclic structures prevalent in biologically active products used widely throughout various disciplines of chemical industry‐including medicine and agriculture. The efficacy these pyrazole species is enhanced through the introduction fluorine corresponding functionalities; therefore, synthetic methods for fluorination appealing which follows overall trend increasing interest chemistry. Toward assimilating known techniques incorporation to...
Asymmetric monomethine cyanines have been extensively used as probes for nucleic acids among other biological systems. Herein we report the synthesis of seven cyanine dyes that successfully prepared with various heterocyclic moieties such quinoline, benzoxazole, benzothiazole, dimethyl indole, and benz[e]indole adjoining benz[c,d]indol-1-ium, which was found to directly influence their optical energy profiles. In this study properties vs. structural changes were investigated using nuclear...
Oxidative stress (OS) plays a major role in the pathogenesis of various diseases humans. OS is result an imbalance between reactive oxygen species (ROS) and biologically available antioxidants that prevent or repair damage ROS inflict on host cells. are naturally generated during normal mitochondrial respiration by oxidative burst immune response. Many factors may influence OS, including genetics, diet, exercise, exposure to environmental toxicants (e.g., tobacco smoke). A nonenzymatic...
In August 2019, the Centers for Disease Control and Prevention (CDC) received first reports of lung injuries that were eventually termed e-cigarette, or vaping, product use–associated injury (EVALI). As part investigation, CDC laboratories rapidly developed assays analyzing substances in bronchoalveolar lavage (BAL) fluid collected from EVALI case patients. This report describes development validation a high-throughput isotope dilution UHPLC-MS/MS method measuring major oxidative stress...
p-Nitro-p′-hydroxyazobenzene, p-hydroxyazobenzene, and p-aminoazobenzene have been oxidized with 30% hydrogen peroxide. It has found that in the case of first two compounds prolonged treatment (25 hr.) disrupts both benzene rings results their complete oxidation to carbon dioxide, water, nitrogen, or oxides nitrogen. Oxidation third compound is not after six days.
Abstract Review: [103 refs.