A5009800175- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Takotsubo Cardiomyopathy and Associated Phenomena
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac pacing and defibrillation studies
- Thermal Expansion and Ionic Conductivity
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiomyopathy and Myosin Studies
- Advanced battery technologies research
- Pulmonary Hypertension Research and Treatments
- Innovative Teaching Methods
- Eosinophilic Disorders and Syndromes
- Bipolar Disorder and Treatment
- Social Media in Health Education
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
University of Cape Town
2018-2025
Universitätsklinikum des Saarlandes
2020-2025
Saarland University
2020-2025
Groote Schuur Hospital
2023-2024
Medizinische Hochschule Hannover
2018-2020
Abstract Background and Aims Peripartum cardiomyopathy (PPCM) remains a serious threat to maternal health around the world. While bromocriptine, in addition standard treatment for heart failure, presents promising pathophysiology-based disease-specific option PPCM, evidence regarding its efficacy limited. This study aimed determine whether bromocriptine is associated with improved outcomes PPCM. Methods patients from EORP PPCM registry available follow-up were included. The main exposure of...
Peripartum cardiomyopathy (PPCM) is an important cause of pregnancy-associated heart failure worldwide. Although a significant number women recover their left ventricular (LV) function within 12 months, some remain with persistently reduced systolic function.Knowledge gaps exist on predictors myocardial recovery in PPCM. N-terminal pro-brain natriuretic peptide (NT-proBNP) the only clinically established biomarker diagnostic value We aimed to establish whether NT-proBNP could serve as...
Abstract Aims Peripartum cardiomyopathy (PPCM) is characterized by left ventricular (LV) dysfunction developing towards the end of pregnancy or in first months postpartum. Although about 60% women with PPCM (the majority which are prescribed evidence based heart failure [HF] medications) show LV recovery within 6 to 12 months, others remain persistently impaired function. Poor adherence medical therapy represents a major cause avoidable hospitalizations, disability, and death other...
Abstract Aims In peripartum cardiomyopathy (PPCM), electrocardiography (ECG) and its relationship to echocardiography have not yet been investigated in large multi‐centre multi‐ethnic studies. We aimed identify ECG abnormalities associated with PPCM, including regional ethnic differences, their correlation echocardiographic features. Methods results studied 411 patients from the EURObservational PPCM registry. Baseline demographic, clinical, data were collected. ECGs analysed for rate,...
Abstract Background ECGs are often taught without clinical context. However, in the setting, rarely interpreted knowing presentation. We aimed to determine whether ECG diagnostic accuracy was influenced by knowledge of context and/or prior exposure diagnosis. Methods Fourth- (junior) and sixth-year (senior) medical students, as well residents were invited complete two multiple-choice question (MCQ) tests a survey. Test 1 comprised 25 case vignettes. 2, completed immediately thereafter, same...
Abstract Background Patients with peripartum cardiomyopathy (PPCM) are at increased risk of sudden cardiac death (SCD). However, the exact underlying mechanisms SCD in PPCM remain unknown. By means extended electrocardiographic monitoring, we aimed to systematically characterize burden arrhythmias occurring patients newly diagnosed PPCM. Methods and results Twenty-five consecutive women were included this single-centre, prospective clinical trial randomised receiving either 24 h-Holter ECG...
Anterior ST-segment depression encompasses important differential diagnoses, including elevation myocardial infarction, non-ST-segment infarction and pulmonary embolism. Diagnostic accuracy is crucial, as this has therapeutic implications. This ECG case report reviews the electrocardiographic changes seen in patients with chest pain anterior depression.
Mobile learning is attributed to the acquisition of knowledge derived from accessing information on a mobile device. Although increasingly implemented in medical education, research its utility Electrocardiography remains sparse. In this study, we explored effect accuracy electrocardiogram (ECG) analysis and interpretation.The study comprised 181 participants (77 fourth- 69 sixth-year students, 35 residents). Participants were randomized analyse ECGs with strategy [either searching Internet...
Poor medication adherence leads to poor health outcomes and increased healthcare costs among patients with heart failure (HF). This study aimed objectively assess by measuring carvedilol enalaprilat plasma concentrations HF.
Abstract Background Patients who have undergone prior pulmonary vein isolation (PVI) for atrial fibrillation (AF) often require a repeat ablation AF recurrence. The optimal ablative strategy the redo procedure and predictors of recurrence thereafter remain largely unknown. Purpose We aimed to characterise strategies applied at re-PVI identify possible Methods Our single-centre, retrospective study included all consecutive patients underwent first PVI our centre from 2017 2022. Inclusion...