A5023090658- Ion Channels and Receptors
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cannabis and Cannabinoid Research
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Paraoxonase enzyme and polymorphisms
- Metal and Thin Film Mechanics
- Mitochondrial Function and Pathology
- Colorectal Cancer Surgical Treatments
- Cardiac Ischemia and Reperfusion
- Biochemical effects in animals
- Respiratory and Cough-Related Research
- Acute Ischemic Stroke Management
- Acute Kidney Injury Research
- Stoma care and complications
- Gout, Hyperuricemia, Uric Acid
- Biochemical Acid Research Studies
- Tryptophan and brain disorders
- Intramuscular injections and effects
- Orthopaedic implants and arthroplasty
- Chemotherapy-induced organ toxicity mitigation
- Parathyroid Disorders and Treatments
- Sepsis Diagnosis and Treatment
Bozok Universitesi
2018-2025
Istanbul University
2025
Erzincan Binali Yıldırım University
2021-2023
Inonu University
2016-2017
ABSTRACT The transient receptor potential ankyrin 1 (TRPA1) channels, characterized as nonselective cation channels with permeability to calcium ions (Ca 2 + ), are part of the extensive family (TRP) channels. Research has demonstrated that TRPA1 function sensors for oxidative stress in renal tubules. Additionally, expression increased tissue following ischemia‐reperfusion (IR). There is also a significant correlation between IR‐induced injury and expression. This study investigated effects...
Dexmedetomidine (dex) is a potent, highly selective and specific α2-adrenoreceptor agonist. This experimental study was designed to investigate protective therapeutic effect of two different doses dex, on kidney damage induced by ischemia-reperfusion (I/R) in rats. Male Sprague−Dawley rats were divided into four groups, each including 10 animals: control group, group; treated groups with μg/kg dex 100 dex. After removing right the rats, left has performed ischemia during 40 min reperfusion...
Apelin is a peptide hormone defined as ligand for G-protein clamped receptor (APJ) receptor. It indicated in the literature both apelin and APJ are synthesized on peripheral tissues including renal tissues. Which roles does play tissue has not been completely illuminated yet. This study designed to determine possible protective effect of apelin-13 kidney I/R injury. Adult male Sprague-Dawley rats were used this study. In sham group, right kidneys animals dissected. was dissected ischemia 45...
It has been revealed in recent studies that Hypericum Perforatum (HP) is influential on cancer, inflammatory diseases, bacterial and viral neuroprotective antioxidant properties. In this study, we investigated the effect of HP, which known to have anti-inflammatory effects, kidney I/R damage. Male Sprague-Dawley rats were divided into three groups, each groups had eight rats: The Control Group; Ischemia/Reperfusion (I/R) IR + HP Group was treated with 50 mg/kg HP. right kidneys removed, left...
Salusin-α and salusin-β are expressed in many tissues including the central nervous system, vessels kidneys; they have been shown to decrease endoplasmic reticulum stress during heart ischemia/reperfusion (I/R) apoptosis. We investigated relation of salusin-α levels acute ischemic renal failure. also whether these peptides protective against I/R damage. Fifty-three rats were divided into six groups: control, I/R, + salusin-α1, salusin-α10, salusin-β1 salusin-β10. After removing right kidney,...
Saxagliptin is an effective and selective dipeptidyl peptidase-4 (DPP-4) inhibitor. This study was designed to determine possible protective effects of saxagliptin against damage caused by renal ischaemia/reperfusion (I/R) in rats. In this study, 40 rats were divided into 4 groups (n = 10 for each). Group 1 (Control), 2 both kidneys ischaemia 45 min performed, then reperfusion applied 24 h. (Group 3: mg/kg 4: mg/kg) administered oral gavage the animals treatment groups, before I/R. decreased...
Psoriasis is a chronic autoimmune disease in which peripheral blood mononuclear cells (PBMCs) are involved the pathological process. Transient receptor potential (TRP) channels expressed immune have been shown to be associated with inflammatory diseases. We aimed evaluate mRNA expression levels of TRP PBMCs patients psoriasis. 30 plaque psoriasis and healthy age- gender-matched control subjects were included this study. determined by Real-time polymerase chain reaction. A decreased TRPM4,...
Abstract Aim Ovarian torsion is a gynecopathology that requires emergency surgery in women. However, ischemia reperfusion injury (IRI) occurs after treatment with detorsion. This study aimed to evaluate the effects of monoacylglycerol lipase inhibitor JZL184 on ovarian IRI and reserve. Methods Forty‐eight female Wistar albino rats were divided into six groups. Group 1: Sham, 2: Ischemia, 3: ischemia/reperfusion (IR), 4: IR + 4 mg/kg, 5: 16 6: vehicle (dimethyl sulfoxide). Three hours...
The production of reactive oxygen species and inflammatory events are the underlying mechanisms ischemia-reperfusion injury (IRI). It was determined that transient receptor potential melastatin-2 (TRPM2) channels phospholipase A2 (PLA 2 ) enzymes were associated with inflammation cell death. In this study, we investigated effect N-( p-amylcinnamoyl) anthranilic acid (ACA), a TRPM2 channel blocker, PLA enzyme inhibitor on renal IRI. A total 36 male Sprague-Dawley rats divided into four...
Abstract Background Neurological diseases such as Alzheimer's disease and Parkinson's (AD, PD), acute ischemic stroke (AIS), multiple sclerosis (MS) are thought to be deeply affected by changes in the pathophysiological processes of neurons. As new peptides, it was aimed evaluate level adropin MOTS‐c (mitochondrial open reading frame 12S rRNA‐c) its possible relationship with NSE (neuron‐specific enolase) NF‐L (neurofilament light chain) terms neuronal interaction. Methods This study...
Transient receptor potential channels have responsibilities in many cellular processes such as cytokine production, cell differentiation, and cytotoxicity by affecting intracellular cation levels or signal pathways. Multiple sclerosis is a chronic autoimmune central nervous system (CNS) disease caused environmental genetic factors. In this study, we aim to investigate TRPV1-TRPV4, TRPM2, TRPM4, TRPM7, TRPC6, TRPA1 mRNA expression levels, which are associated with the inflammatory process,...
Giriş ve Amaç: Hücre içi kalsiyum (Ca2+) sinyali; hücre proliferasyonu farklılaşması, gen transkripsiyonu, apoptozis gibi birçok hücresel süreçte rol oynar. Yapılan çalışmalarda Ca2+ sinyalinin kanser ile ilişkili olduğu gösterilmiştir. Transient receptor potential vanilloid 4 (TRPV4) kanalları zarında bulunan geçirgen non-selekif katyon kanalıdır. TRPV4 vücutta dokuda yaygın olarak eksprese edilmektedir. miktarının düzenlenmesinde etkisi olan kanallarının hücrelerinin proliferasyonu,...
Aim: This study aims to evaluate the effects of alpha lipoic acid (ALA), which is a strong antioxidant, on endometriosis (EMS).Methods: Thirty sexually-mature, female Wistar albino rats weighing 180-220 grams were separated into three groups: sham (n=10), EMS (n=10) and + ALA (n=10).Blood samples taken from centrifuged stored at -80 °C before forming experimental model.ALA dose 50 mg/kg was orally administered group.At end this procedure, blood again °C.Plasma total antioxidant status (TAS),...