A5072400587- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Mitochondrial Function and Pathology
- X-ray Diffraction in Crystallography
- Particle accelerators and beam dynamics
- Crystallization and Solubility Studies
- Particle Accelerators and Free-Electron Lasers
- Cell death mechanisms and regulation
- Nicotinic Acetylcholine Receptors Study
- stochastic dynamics and bifurcation
- Electrochemical Analysis and Applications
- Magnetic confinement fusion research
- Photoreceptor and optogenetics research
- DNA and Nucleic Acid Chemistry
- Heat shock proteins research
- Neuroscience and Neural Engineering
- Connexins and lens biology
- Mosquito-borne diseases and control
- ATP Synthase and ATPases Research
- Microfluidic and Capillary Electrophoresis Applications
- Protein Structure and Dynamics
- Spectroscopy and Quantum Chemical Studies
- Superconducting Materials and Applications
University of Delhi
2015-2025
Guru Ghasidas Vishwavidyalaya
2025
Technische Universität Dresden
2016
University of Hyderabad
2005-2006
Inter-University Accelerator Centre
2000-2002
Jawaharlal Nehru University
1981-1986
University of Iowa
1963
Viroporins like influenza A virus M2, hepatitis C p7, HIV-1 Vpu and picornavirus 2B associate with host membranes, create hydrophilic corridors, which are critical for viral entry, replication egress. The 6K proteins from alphaviruses conjectured to be viroporins, essential during egress of progeny viruses although the analogue in Chikungunya Virus (CHIKV) remains relatively uncharacterized. Using a combination electrophysiology, confocal electron microscopy, molecular dynamics simulations...
Alphaviruses, a genus of vector-borne viruses in the Togaviridae family, encode small ion-channel-forming protein, 6K, and its transframe variant (TF) during infections. Although 6K/TF have vital roles glycoprotein transport, virus assembly, budding, there is no mechanistic explanation for these functions. We investigated distinct biochemical functionalities 6K TF from mosquito-borne alphavirus, Chikungunya Virus. show that like also capable forming ion channels bilayer membranes. The...
Aims: This study aimed to investigate novel therapeutic approaches for Alzheimer's disease (AD) by targeting the Transforming Growth Factor-β (TGF-β) pathway using hybrid compounds derived from oxymatrine and amino acids. Background: AD remains a significant challenge in neurodegenerative disorders, necessitating innovative treatments that can mitigate its devastating effects. The TGF-β has been implicated pathogenesis, making it promising target intervention. Objective: objective of this...
Abstract Apoptosis is a controlled form of cell death that participates in development, elimination damaged cells and maintenance homeostasis. Also, it plays role neurodegenerative disorders like Alzheimer's disease. Recently, mitochondria have emerged as being pivotal controlling apoptosis. They house number apoptogenic molecules, such cytochrome c , which are released into the cytoplasm at onset When rat brain mitochondrial voltage‐dependent anion channel (VDAC), an outer membrane protein,...
Noise profile of Voltage Dependent Anion Channel (VDAC) is investigated in open channel state. Single-channel currents through VDAC from mitochondria rat brain reconstituted into a planar lipid bilayer are recorded under different voltage clamped conditions across the membrane. Power spectrum analysis current indicates power law noise 1/f nature. Moreover, this nature seen throughout range applied membrane potential -30 to +30 mV. It being proposed that ion arises out obstruction passage...
Voltage-Dependent Anion Channel (VDAC) phosphorylated by c-Jun N-terminal Kinase-3 (JNK3) was incorporated into the bilayer lipid membrane. Single-channel electrophysiological properties of native and VDAC were compared. The open probability versus voltage curve displayed symmetry around axis, whereas that showed asymmetry. This result indicates phosphorylation JNK3 modifies voltage-dependence VDAC.
Abstract The membrane capacitance has been shown to have a nonlinear dependence on the cell potential in various types of cells. But role neurons not studied detail. Herein, by considering be parameter, we explored behavior three different neurons, i.e. , squid giant neuron, rodent hippocampal interneuron, and cortical neuron. Hodgkin-Huxley equation action was modified accordingly simulated computationally. Our results suggest that amplitude neuron almost remains same for some duration when...
KvAP is a voltage-gated tetrameric K(+) channel with six transmembrane (S1-S6) segments in each monomer from the archaeon Aeropyrum pernix. The objective of present investigation was to understand plausible role S6 segment, which has been proposed form inner lining pore, membrane assembly and functional properties channel. For this purpose, 22-residue peptide, corresponding segment (amino acids 218-239), scrambled peptide (S6-SCR) rearrangement only hydrophobic amino but without changing its...
For many driven-nonequilibrium systems, the probability distribution functions of magnitude and recurrence-time large events follow a powerlaw indicating strong temporal correlation. In this paper we argue why these are ubiquitous in driven nonequilibrium derive universal scaling laws connecting magnitudes, recurrence-time, spatial intervals events. The relationships between exponents have also been studied. We show that ion-channel current Voltage-dependent Anion Channels obeys law.
Collective behavior of S6 peptide channels derived from KvAP (a bacterial potassium channel) incorporated in lipid bilayer membrane, has been investigated at various applied potentials through multi-channel electrophysiological experiments. The current versus time traces any particular membrane potential show clear steps for sequential opening the multi-channels. minimum (representing one-channel current) was found out amplitude histograms. Accordingly, number open corresponding to a state...
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a key enzyme that plays significant role in intracellular signaling and the modulation of mitochondrial membrane properties. It known voltage-dependent anion channel (VDAC) one most abundant outer (OMM) proteins acting as passageway regulatory site for various enzymes, proteins, ions, metabolites. Considering this, we hypothesize VDAC could be targets CaMKII enzymatic activity. Our vitro experiments indicate can phosphorylated by...
Abstract The fluorescence studies of E. coli porin OmpF at pH 7.5 were carried out using excitation 280 and 305 nm. Similar performed in presence a denaturant (urea) quencher (KI). Results show that both the tryptophans present (residue numbers 61 214) contribute to nm excitation, whereas only one residue shows emission when excited Based on these findings available crystal structure, it is speculated tryptophan selectively point some interesting features microenvironments OmpF.