A5045520061- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Tuberculosis Research and Epidemiology
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Retinal Development and Disorders
- MicroRNA in disease regulation
- Synthesis of β-Lactam Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Dental materials and restorations
- Pharmaceutical and Antibiotic Environmental Impacts
- Molecular Biology Techniques and Applications
- Dental Trauma and Treatments
- Cognitive Science and Mapping
- Gene expression and cancer classification
- Trace Elements in Health
- Antibiotic Use and Resistance
- Orthodontics and Dentofacial Orthopedics
- Bacterial biofilms and quorum sensing
Duke University
2018-2024
Environmental Protection Agency
2020
National Institute of Standards and Technology
2015
University of Maryland, Baltimore County
2015
American Dental Association
2015
The short average service life of traditional dental composite restorative materials and increasing occurrence secondary caries adjacent to restorations sealants are necessitating the development new, longer lasting compositions. Novel monomers their polymers, reinforcing fillers, adhesive components needed. goal this research is develop resin systems for use in restorations, sealants, other services that superior properties endurance currently used bisphenol A glycidyl...
The unabated rise in bacterial resistance to conventional antibiotics, coupled with collateral damage normal flora incurred by overuse of broad-spectrum necessitates the development new antimicrobials targeted against pathogenic organisms. Here, we explore antibacterial outcomes and mode action a prochelator that exploits production β-lactamase enzymes drug-resistant bacteria convert nontoxic compound into metal-binding antimicrobial agent directly within microenvironment Compound PcephPT...
Antibacterial drug resistance is a rapidly growing clinical threat, partially due to expression of β-lactamase enzymes, which confer bacteria by hydrolyzing and inactivating β-lactam antibiotics. The increasing prevalence metallo-β-lactamases poses unique challenge, as currently available inhibitors target the active site serine β-lactamases but are ineffective against zinc-containing sites metallo-β-lactamases. There an urgent need for metallo-β-lactamase antibiotics that circumvent...
Abstract Environmental exposure to metals is known cause a number of human toxicities including cancer. Metal-responsive transcription factor 1 (MTF-1) an important component metal regulation systems in mammalian cells. Here, we describe novel method identify chemicals that activate MTF-1 based on microarray profiling data. biomarker genes were identified exhibited consistent, robust expression across 10 comparisons examining the effects (zinc, nickel, lead, arsenic, mercury, and silver)...
Abstract Bacterial expression of β‐lactamases, which hydrolyze β‐lactam antibiotics, contributes to the growing threat antibacterial drug resistance. Metallo‐β‐lactamases, such as NDM‐1, use catalytic zinc ions in their active sites and nearly all clinically available antibiotics. Inhibitors metallo‐β‐lactamases are urgently needed overcome this resistance mechanism. Zinc‐binding compounds promising leads for inhibitor development, many NDM‐1 inhibitors contain zinc‐binding pharmacophores....
Abstract The rise of β-lactam resistance necessitates new strategies to combat bacterial infections. We purposefully engineered the prodrug AcephPT exploit β-lactamase activity selectively suppress resistant bacteria producing extended-spectrum-β-lactamases (ESBLs). Selective targeting requires avoiding interaction with penicillin-binding proteins, conventional targets antibiotics, while maintaining recognition by ESBLs activate only in cells. Computational approaches provide a rationale for...