Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with very poor prognosis as it has 2.5 to 5 years mean survival after proper diagnosis. Even nintedanib and pirfenidone cannot halt the progression, though they slow progression of IPF. Hence, there need understand novel pathophysiology. Phospholipase A2 (PLA2) could be ideal candidate study in IPF, have role both inflammation fibrosis. In present study, we shown expression profile various secretory isoforms by analyzing publicly...

Multi-system inflammatory syndrome in children (MIS-C) associated with COVID-19 is a recently recognised potentially life-threatening entity. There limited data on post-MIS-C sequelae. 21 fulfilling the WHO criteria for MIS-C were included our study. Data collected at baseline and 12–16 weeks post-discharge to look any persistent sequelae mainly relating lungs or heart including coronary arteries. Fever was most common presentation, found 18 (85.7%) patients. All had marked...

Abstract Influenza, a significant cause of seasonal morbidity and mortality, can lead to severe complications affecting multiple organ systems. This case series highlights the diverse manifestations influenza-related dysfunction in children such as myocarditis, acute respiratory distress syndrome, kidney injury, necrotizing encephalopathy, liver failure, influenza-associated encephalopathy. emphasizes critical need for early recognition aggressive management influenza cases, given potential...

Sepsis is one of the leading causes morbidity and mortality in children. The aim our study was to compare procalcitonin-to-albumin ratio (PAR) C-reactive protein(CRP)-to-albumin (CAR) predicting sepsis its severity children know which better. This prospective observational conducted a tertiary care hospital from July 2022 January 2024. Procalcitonin, CRP, albumin, along with baseline investigations, were sent on day admission (day 0), 2 admission, 7 for all suspected sepsis. included 118...

Background: Multiple choice questions (MCQs) are usually used to assess students in different educational streams. However, the MCQs be should of quality which depends upon its difficulty index (DIF I), discrimination (DI) and number Non-functional distracter (NFD). Objective study is evaluate MCQs, for creating a valid question bank future use identify low achievers, whose problems can corrected by counselling or modifying learning methods. This was done Kalinga Institute Medical Science...

Lot of work has already been done for automatic text summarization.In this paper we have given a novel statistical approach to summarize the text.In our extraction relevant sentences is which can give actual concept input document in concise form.We rank each sentence by assigning weight value word and boost factor also added those terms appear bold, italic or underlined any combination these features.It helps us extract more will lead good summary text.

Background: In developing countries, there is scarce data on paediatric critical care. This makes modification of practices to improve outcome, difficult. The above study was done highlight the lack facilities and concept pediatric in eastern part India so that management can lead better outcome critically ill children.Methods: A retrospective demography, clinical profile, diagnosis, treatment children admitted PICU Kalinga Institute Medical Sciences from January 2014 December 2015 done....

Lot of work has already been done for automatic text summarization.In this paper we have given a novel statistical approach to summarize the Odia text.In our extraction relevant sentences is which can give actual concept input document in concise form.We rank each sentence by assigning weight value word sentence.The are extracted as per their rank, will lead good summary text.

Brief Communication IntroductIonAutoimmune encephalitis (AIE) is a difficult clinical diagnosis as the imaging and laboratory findings mimic many forms of autoimmune infectious encephalitis. [1]These noninfectious causes are diagnostic priority they treatable if diagnosed early delay in treatment can be life-threatening.They associated with an underlying malignancy or systemic disease.A careful history examination may give clues such cognitive disturbances, mood/ personality changes, memory...

Following an asymptomatic or mildly symptomatic coronavirus disease (COVID-19), otherwise healthy children may develop serious manifestations in the form of cardiac, neurological, respiratory, gastrointestinal, and dermatologic dysfunction. Many such cases were being observed Odisha, eastern state India, have been reported from different health-care facilities. We related these unexplained to multisystem inflammatory syndrome associated with COVID-19 (MIS-C) planned this study.This...

Background: Nosocomial infection, due to Candida, contracted in the pediatric intensive care unit (PICU), is emerging as a significant healthcare challenge. The incidence of non-albicans Candida cause candidemia on rise, unlike previous decades. Materials and Methods: All cases confirmed by culture, admitted PICU during study period January 2017 December 2019, were retrospectively studied. prevalence, speciation, sensitivity pattern risk factors mortality recorded analyzed. Results: There...

Background: Scrub typhus was unseen in Odisha, but during postmonsoon months of 2014, for the first time, 25 cases scrub were identified pediatric department Kalinga Institute Medical Sciences, Bhubaneswar. Objectives: This study aimed at analyzing demographic pattern, symptomatology, complications, and response to therapy, which will help medical fraternity early diagnosis management. Materials Methods: By retrospective analysis case records between September 2014 February 2015, children...

Introduction: The need for mechanical ventilation (MV) is an absolute indication admission to Paediatric intensive care unit (PICU). Management of children requiring invasive in resource limited developing countries challenging. Scare data available from Asian regarding use MV PICUs. objectives this study were determine the clinical profile, characteristics, common causes ventilation, related complications and final outcome these patients.Material Methods: A retrospective ventilator support...

Japanese encephalitis (JE) is the important cause of Acute Encephalitis Syndrome (AES). However, in large proportion AES cases, specific cannot not be established. For this, scrub typhus one such emerging cause. In line with first case report on Odisha due to encephalopathy paediatric age group presented.J Nepal Paediatr Soc 2016;36(3):307-309

Abstract Inherited causes of cavernous venous sinus thrombosis (CVST) leading to stroke in infancy are rare. Methylenetetrahydrofolate reductase (MTHFR) gene mutation is one such cause. Polymorphism MTHFR, an essential enzyme Vitamin B12 metabolism, leads increase homocysteine levels. This a prothrombotic state and, therefore, pediatric stroke. Children with the MTHFR have elevated The index case polymorphism CVST stoke had normal level. association A1298C can be confirmed only after further...

Abstract: The most common self-limiting viral infection of the lower respiratory tract in pediatric population is bronchiolitis, which commonly affects infants. In cases, syncytial virus (RSV) causative agent. general, recovery occurs within 5–7 days without any complications. Spontaneous pneumothorax one rare and less-reported complications bronchiolitis. We report a case male child aged 5 months with bilateral spontaneous (PNO) subcutaneous emphysema following nasopharyngeal swab was...

Abstract Background Multi System Inflammatory Syndrome in children (MIS-C) associated with COVID-19 is a recently recognised potentially life-threatening entity. There limited data on post MIS-C sequelae. Methods 21 fulfilling the WHO criteria for were included our study. Data was collected at baseline and 12-16 weeks discharge to look any persistent sequelae mainly relating lungs or heart including coronary arteries Results Fever most common presentation, found 18 (85.7%) patients. All had...

This retrospective, observational study was conducted by collecting data from medical records during COVID 19 pandemic March 2020 till August 2020. compared with the of 2019 similar months. The impact on use preventive and curative paediatric health care service units like outpatient department, casualty, intensive immunization clinic were assessed. Data to using standard parametric nonparametric tests. There a significant decline in routine OPD (68%) attendance period as pre-COVID period....

Snakebite is a commonly seen problem in tropical countries like India. Early morning neuroparalytic syndrome and cranial nerve palsies are the usual presentations. Locked-in (LIS) rare presentation. We present 1-year 6-month-old female toddler with acute onset of weakness all four limbs, who developed LIS. The patient was given anti-snake venom on day 3 admission fully recovered after weeks ventilation. should be suspected any child presenting early-onset or LIS even if there no history...