A5041694394- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Mechanical Circulatory Support Devices
- Ultrasound in Clinical Applications
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Vascular Anomalies and Treatments
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Coronary Artery Anomalies
- Tryptophan and brain disorders
- Cardiovascular and Diving-Related Complications
- Cancer, Hypoxia, and Metabolism
- Hemodynamic Monitoring and Therapy
- Tissue Engineering and Regenerative Medicine
- Spaceflight effects on biology
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
Children's Hospital Colorado
2016-2025
University of Colorado Denver
2016-2025
University of Colorado Anschutz Medical Campus
2020-2025
University of Colorado Health
2020
Columbia University Irving Medical Center
2020
RELX Group (United States)
2019
Cornell University
2010-2011
Children's Mercy Hospital
2010
Rush University Medical Center
2006
University of Applied Sciences Landshut
1996
Background Mortality for infants undergoing complex cardiac surgery is >10% with a 30% to 40% risk of complications. Early identification and treatment high-risk remains challenging. Metabolites are small molecules that determine the minute-to-minute cellular phenotype, making them ideal biomarkers postsurgical monitoring potential targets intervention. Methods Results We measured 165 serum metabolites by tandem mass spectroscopy in ≤120 days old cardiopulmonary bypass. Samples were...
Infants with SVHD experience morbidity related to pulmonary vascular inadequacy. Metabolomic analysis involves a systems biology approach identifying novel biomarkers and pathways in complex diseases. The metabolome of infants is not well understood no prior study has evaluated the relationship between serum metabolite patterns readiness for staged palliation. purpose this was evaluate circulating interstage single ventricle heart disease (SVHD) determine whether levels were associated This...
The combination of a carotid-basilar and vertebro-vertebral collateral circulation was verified directly in patient with complete subclavian steal by means transcranial Doppler ultrasonography. showed permanently reversed blood flow the basilar artery. influenced hemodynamics circle Willis at rest during functional tests collaterally supplied arm. Our investigation provides first direct experimental evidence increased velocity carotid artery after decompressing
Coronary artery disease (CAD) is common in patients with abdominal aortic aneurysms (AAA). Some will present the combination of unstable angina, impaired left ventricular function, and a large symptomatic (ie, leaking, expanding) AAA. In this subgroup high-risk patients, cross-clamping may have deleterious effect on cardiac whereas coronary bypass graft surgery before aneurysmectomy (staged operation) carries risk perioperative aneurysm rupture. One-stage surgery, ie, myocardial...
OBJECTIVE. The purpose of this article is to review the outcomes patients with malignant biliary obstruction treated by immediate placement a metallic stent at time percutaneous drainage.
Adverse ventricle-ventricle interaction and resultant left ventricular (LV) dysfunction are a recognized pathophysiological component of disease progression in pulmonary arterial hypertension (PAH) can be associated with electrical mechanical dyssynchrony. The purpose this study was to investigate the clinical mechanistic implications LV electromechanical dyssynchrony children PAH by using novel systolic stretch diastolic relaxation discoordination indexes derived noninvasively from cardiac...
Disturbed balance between matrix metalloproteinases (MMPs) and their respective tissue inhibitors (TIMPs) is a well-recognized pathophysiological component of pulmonary arterial hypertension (PAH). Both classes proteinases have been associated with clinical outcomes as well specific pathological features ventricular dysfunction remodeling. The purpose this study was to evaluate the circulating levels MMPs TIMPs in children PAH undergoing same-day cardiac magnetic resonance imaging (MRI)...
Kawasaki Disease (KD), a systemic vasculitis of medium sized vessels, is the most common cause acquired heart disease among children in developed world. Some KD patients demonstrate echocardiographic evidence depressed myocardial mechanics. However, incidence, etiology, and reversibility abnormal mechanics remain undefined.We retrospectively studied 41 measured strain rate by velocity vector imaging from pre-treatment convalescent echocardiograms. Pre-treatment procalcitonin, C-reactive...
Multiple right ventricular (RV) metrics have prognostic value in pulmonary hypertension (PH). A cardiac magnetic resonance imaging (CMR) derived global function index (GFI) provided improved prediction of composite adverse outcome (CAO) adults with atherosclerosis. GFI has not yet been explored a PH population. We the feasibility as predictor CAO pediatric Two center retrospective chart review identified patients undergoing CMR from Jan 2005–June 2021. GFI, defined ratio stroke volume to sum...
This cohort study assesses proteins measured in infancy and neurodevelopmental outcomes single ventricle heart disease.
Preliminary evidence suggests perturbations of the kynurenine pathway (KP) tryptophan metabolism in infants with single ventricle heart disease (SVHD). In 72 SVHD undergoing stage 2 palliation (S2P) and 41 controls, we quantified serum KP metabolite concentrations via tandem mass spectroscopy pre-S2P post-S2P at 2, 24, 48 h assessed relationships outcomes (length stay, hypoxemia burden, intubation duration). Pre-S2P, had lower serotonin levels higher kynurenic acid, 3-hydroxykynurenine,...