A5047935987- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Mental Health Treatment and Access
- Suicide and Self-Harm Studies
- Metabolomics and Mass Spectrometry Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Healthcare Systems and Public Health
- S100 Proteins and Annexins
- Neurogenesis and neuroplasticity mechanisms
- Alcohol Consumption and Health Effects
- Substance Abuse Treatment and Outcomes
- Neuroscience and Neuropharmacology Research
- Bipolar Disorder and Treatment
- Nerve injury and regeneration
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroendocrine regulation and behavior
- Gut microbiota and health
- Treatment of Major Depression
- Neuroscience of respiration and sleep
- Human Health and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Vitamin D Research Studies
Tomsk National Research Medical Center
2020-2025
Russian Academy of Sciences
2021-2025
Mental Health Research Institute
2023-2025
Background: the comorbidity of depressive disorders (DD) and alcohol dependence (AD) negatively affects clinical dynamic characteristics disorders, as well manifestations aggressiveness in these patients. The aim was to evaluate impact DD AD on main aggressiveness. Patients Methods: 182 patients were selected departments affective addictive states Mental Health Research Institute, Tomsk National Medical Center. study group divided into a according ICD-10 classification (n = 132) with...
To assess the influence of comorbid affective disorders (AD) on clinical and dynamic indicators alcohol dependence syndrome (ADS), level aggression in patients, to examine gender differences. Two groups were analyzed: Group F10 (n = 149) included patients with ADS without AD, group + F3 61) AD. Clinical-psychopathological, clinical-follow-up, psychometric, statistical methods used. Comorbidity AD reduces differences duration lucid periods, depressogenic effects alcohol, levels physical...
Alcohol Use Disorder (AUD) and depressive disorder often co-exist have a shared heritability. This study aimed to investigate Brain-Derived Neurotrophic Factor (BDNF) three Cell Adhesion Molecules (CAMs) as transdiagnostic biomarkers in AUD depression co-morbidity. In cross-sectional study, patients with (n=22), (n=19), healthy controls (n=20) were examined. Depression anxiety severity assessed using the Hamilton Rating Scale Anxiety Scale. Anhedonia, alcohol use dependence, craving, social...
Because alcohol use disorder (AUD) is often accompanied by mood (MD) and both alcoholism depression result in activation of the immune system, this study compares serum cytokine levels presence co-morbidity with those either AUD or MD alone.In naturalistic prospective 15 different cytokines were measured samples patients (n = 43), participants combined AUD-MD 44) without 42). The compared cross-sectionally among themselves 50 healthy volunteers.Pro-inflammatory IFN-2α consistently...
Nowadays, nervous tissue damage proteins in serum are considered promising drug targets and biomarkers of Mood Disorders. In a cross-sectional naturalistic study, the S100B, MBP GFAP levels blood were compared between two diagnostic groups (patients with Depressive Episode (DE, n = 28) patients Recurrent Disorder (RDD, 21)), healthy controls (n 25). The value markers was assessed by ROC analysis. DE group, we did not find changed controls. RDD found decreased S100B level (p 0.011) increased...
Depressive disorder is a multifactorial disease that based on dysfunctions in mental and biological processes. The search for biomarkers can improve its diagnosis, personalize therapy, lead to deep understanding of the biochemical processes underlying depression. purpose this work was metabolomic analysis blood serum classify patients with depressive disorders healthy individuals using Compound Discoverer software. Using high-resolution mass spectrometry, plasma samples from 60 people were...
The neuropeptides β-endorphin and oxytocin are released into the bloodstream as hormones from pituitary gland but also have an important function neuroregulators in forebrain. blood levels of both polypeptides been shown to reflect depressive symptoms. β-Endorphin, particular, is involved abstinence alcohol. serum were measured during early withdrawal phase patients with alcohol use disorder (AUD) (N = 35) or without 45) comorbidity compared those healthy volunteers 23). In addition...
To establish the differences and identify prognostic value of biological markers - platelet growth factors PDGF-AA, PDGF-BB brain-derived neurotrophic factor (BDNF) for differential diagnosis patients with unipolar bipolar depression using machine learning.
Background : depressive disorders remain an important medical problem and present significant economic social burden on the health care system. This sets task for scientific community to increase level of their detection, treatment prevention. It seems promising study role markers neuronal disorders, in particular, proteins S-100, MBP, GFAP, pathogenesis primary recurrent disorders. Purpose determine relationship between clinical psychopathological characteristics (anxiety, depression,...