A5028665290- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Inorganic Fluorides and Related Compounds
- Fluorine in Organic Chemistry
- Protein purification and stability
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Carbon dioxide utilization in catalysis
- Cancer, Lipids, and Metabolism
- Advanced Chemical Sensor Technologies
Jiangsu Hengrui Medicine (China)
2023
Chinese Academy of Sciences
2012-2020
Shanghai Institute of Organic Chemistry
2012-2020
Dual action: The Lewis acid CuF2⋅2 H2O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β-unsaturated carboxylic acids by dually activating both reactants, thus affording di- trifluoromethyl alkenes in high yields with excellent E/Z selectivity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note:...
Doppelfunktion: Die Lewis-Säure CuF2⋅2 H2O katalysiert effizient die Umsetzung von α,β-ungesättigten Carbonsäuren mit elektrophilen Fluoralkylierungsreagentien, Di- und Trifluormethylalkene in hohen Ausbeuten ausgezeichneter E/Z-Selektivität liefert. Das Kupfersalz aktiviert dabei beide Reaktanten. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the...
In this work, we developed a rapid and high-sensitivity method for simultaneous analyses of fatty alcohols, aldehydes, sterols by combining the optimized derivatization reaction with electrospray ionization-ion mobility-mass spectrometry (ESI-IM-MS). Pyridine thionyl chloride were used as reagents they easily removed after could generate permanently charged tags on different functional groups including hydroxyls aldehydes. Through one-step reaction, sensitivity detection was significantly...
In-depth characterization of charge heterogeneity is a pivotal step desired in the therapeutics antibody development. To this end, novel on-line multidimensional liquid chromatography-mass spectrometry (MDLC-MS) method for variant was developed to dig out potential risks on safety and efficacy. This implemented 96-well plate fractionation on-column preconcentration by multi-injection, thereby facilitating detection charged species at low abundance. Eleven variants mAb-A were preliminarily...
Abstract The copper reagent and the carboxylic acid group in substrates play an important role new effective protocol for title synthesis.