A5016402147- Metal complexes synthesis and properties
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- Microbial Community Ecology and Physiology
- RNA Research and Splicing
- Polysaccharides and Plant Cell Walls
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Polysaccharides Composition and Applications
- Biofuel production and bioconversion
- Soil Carbon and Nitrogen Dynamics
- Genetics and Neurodevelopmental Disorders
- Food composition and properties
- Inorganic and Organometallic Chemistry
- Legume Nitrogen Fixing Symbiosis
- Ferrocene Chemistry and Applications
- Insect Resistance and Genetics
- Autism Spectrum Disorder Research
- Arsenic contamination and mitigation
- Chromium effects and bioremediation
- RNA modifications and cancer
- Seed and Plant Biochemistry
- Transgenic Plants and Applications
- Magnetism in coordination complexes
- Soil Management and Crop Yield
University of Calcutta
2006-2020
Duke Medical Center
2000-2001
Indian Institute of Chemical Biology
1997-2000
Duke University Hospital
2000
Compelling in vivo studies suggest a tight functional linkage between RNA polymerase II transcription and pre-messenger splicing. At present, the specific interactions involved this coupling are poorly understood deserve investigation. To end, we developed an vitro system that permits study of coupled Transcripts generated by were accurately efficiently spliced under reaction conditions permitted both splicing to occur simultaneously. The RNA-polymerase-II-driven transcripts was accelerated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on gold(II) complexes with hard and soft donor ligands. 3. Complexes N-(2-pyridylmethyl)-2-mercaptoanilineA. P. Koley, R. Nirmala, L. S. Prasad, Ghosh, T. ManoharanCite this: Inorg. Chem. 1992, 31, 10, 1764–1769Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 1992https://pubs.acs.org/doi/10.1021/ic00036a009https://doi.org/10.1021/ic00036a009research-articleACS PublicationsRequest reuse...
The effect of pH the assay media and different carbon sources in culture on activities 4 enzymes, namely polygalacturonase (PG), pectin lyase (PNL), xylanase, cellulase, some pectinolytic bacteria were studied. bacterial strains isolated from jute retting water bodies 2 important growing areas North 24 Parganas, West Bengal, India. highest PG (12.45 to 41.0 IU/g cell wet weight) PNL (22.55 75.7 U/mL) occurred at alkaline 8.0 8.5, respectively. Maximum xylanase activity (0.01 0.735...
Retention of unspliced pre‐messenger RNA (pre‐mRNA) in the nucleus is essential for cell survival. Available nuclear factors must recognize and discern between diverse export signals present pre‐mRNA to establish an inhibitory complex. We found that polypyrimidine domains both intron exon were important inhibition a minigene transcript based on hepatitis B virus pregenomic RNA. Overexpression PTB drastically reduced presence RRM4 domain seemed critical. This network overrode stimulation from...
Small RNA (sRNA)-mediated regulation of gene expression is a major tool to understand bacterial responses environmental changes. In particular, pathogenic bacteria employ sRNAs adapt the host environment and establish infection. Members Burkholderia cepacia complex, normally present in soil microbiota, cause nosocomial lung infection especially hospitalized cystic fibrosis patients. We sequenced draft genome cenocepacia KC-01, isolated from coastal saline soil, identified several potential...
A double-headed chymotrypsin inhibitor, WCI, from winged bean seeds was cloned for structural and biochemical studies. The inhibitor subjected to two point mutations at a conserved position, Asn14. This residue, known have pivotal role in stabilizing the first reactive-site loop (Gln63–Phe68) of is highly sequences other members Kunitz (STI) family as well Kazal serine protease inhibitors. mutants, N14K N14D, were assay their characteristics compared with those recombinant (rWCI)....
Retting of jute is essentially microbiological and biochemical in nature. Community Level Physiological Profiles (CLPP) as well genomic diversity bacterial communities were assessed water samples collected during pre-retting, after 1st 2nd charges retting. The from two widely cultivated growing locations, Sonatikari (22 degrees 41'27"N; 88 35'44"E) Baduria 44'24"N; 47'24"E), West Bengal, India. CLPP, expressed net area under substrate utilization curve, was studied by carbon source patterns...
HBV particles with genome derived from spliced mRNAs accumulate in patients virus-derived severe liver necrosis and fibrosis. We investigated the role of an intronic element (intronic splicing silencer-long, ISS(L)) on minigene transcripts. Removal entire ISS(L) showed two-fold increase while shorter deletions within indicated isolated clusters activator repressor domains. Activator domains stimulated presence PRE, a long 3' exon even when present heterologous context. Mutations domain...
Abstract The direct method program SAYTAN has been applied successfully to redetermine the structure of cytochrome c 6 , a heme-containing redox protein with 89 amino acids, Fe atom and 151 solvent water molecules in asymmetric unit data 1.1 Å resolution. crystal system is rhombohedral space group R3, cell parameters = b 40.43(10) Å, α β γ 80.25(5)°. Starting initially random phases, useful phase sets could be obtained from multiple trials methods based on reciprocal space. E-map...