A5085429200- Neurobiology and Insect Physiology Research
- Hippo pathway signaling and YAP/TAZ
- Neuroendocrine regulation and behavior
- Insect Utilization and Effects
- Protease and Inhibitor Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Signaling Pathways in Disease
- Attachment and Relationship Dynamics
- Insect and Arachnid Ecology and Behavior
- Evolutionary Psychology and Human Behavior
- Stress Responses and Cortisol
- Peptidase Inhibition and Analysis
- Bacteriophages and microbial interactions
- Olfactory and Sensory Function Studies
- Genomics and Phylogenetic Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Anesthesia and Neurotoxicity Research
- Cellular transport and secretion
- Glycosylation and Glycoproteins Research
- Neuroscience and Neuropharmacology Research
Emory University
2015-2025
Scripps Research Institute
2016-2022
Emory National Primate Research Center
2015
University of Hawaii System
2009-2010
Pacific Biosciences (United States)
2010
Anatomical and physiological compartmentalization of neurons is a mechanism to increase the computational capacity circuit, major question what role axonal plays. Axonal may enable localized, presynaptic plasticity alter neuronal output in flexible, experience-dependent manner. Here, we show that olfactory learning generates compartmentalized, bidirectional acetylcholine release varies across longitudinal compartments Drosophila mushroom body (MB) axons. The directionality learning-induced...
Abstract Neurofibromatosis I is a common genetic disorder that results in tumor formation, and predisposes individuals to range of cognitive/behavioral symptoms, including deficits attention, visuospatial skills, learning, language development, sleep, autism spectrum disorder-like traits. The nf1-encoded neurofibromin protein (Nf1) exhibits high conservation, from the fruit fly, Drosophila melanogaster, humans. provides powerful platform investigate signaling cascades upstream downstream...
Abstract Neurofibromatosis type 1 is a chronic multisystemic genetic disorder that results from loss of function in the neurofibromin protein. Neurofibromin may regulate metabolism, though underlying mechanisms remain largely unknown. Here we show regulates metabolic homeostasis Drosophila via discrete neuronal circuit. Loss increases rate Ras GAP-related domain-dependent mechanism, feeding homeostatically, and alters lipid stores turnover kinetics. The increase independent locomotor...
Neurofibromatosis type 1 is a monogenetic disorder that predisposes individuals to tumor formation and cognitive behavioral symptoms. The neuronal circuitry developmental events underlying these neurological symptoms are unknown. To better understand how mutations of the gene (NF1) drive alterations, we have examined grooming in Drosophila neurofibromatosis model. Mutations fly NF1 ortholog excessive grooming, increased was observed adults when Nf1 knocked down during development....
Abstract Anatomical and physiological compartmentalization of neurons is a mechanism to increase the computational capacity circuit, major question what role axonal plays. Axonal may enable localized, presynaptic plasticity alter neuronal output in flexible, experience-dependent manner. Here we show that olfactory learning generates compartmentalized, bidirectional acetylcholine release varies across longitudinal compartments Drosophila mushroom body (MB) axons. The directionality...
ABSTRACT Neurofibromatosis type 1 (NF1) is a genetic disorder predisposing patients to range of features, the most characteristic which include areas abnormal skin pigmentation and benign tumors associated with peripheral nerves, termed neurofibromas. Less common, but more serious symptoms also malignant nerve sheath tumors, other malignancies, learning disabilities. The NF1 gene encodes neurofibromin, large protein that functions as negative regulator Ras signaling mediates pleiotropic...