A5038399151- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Social and Educational Sciences
- Asthma and respiratory diseases
- Acute Myocardial Infarction Research
- Artificial Intelligence in Healthcare and Education
- SARS-CoV-2 and COVID-19 Research
- Autopsy Techniques and Outcomes
- Cardiac Imaging and Diagnostics
- Manufacturing Process and Optimization
- SARS-CoV-2 detection and testing
- Cutaneous Melanoma Detection and Management
- Cardiac Fibrosis and Remodeling
- Intellectual Property and Patents
- Business Process Modeling and Analysis
- Nonmelanoma Skin Cancer Studies
- Quality and Supply Management
- Colorectal Cancer Surgical Treatments
- Corporate Finance and Governance
- Biosensors and Analytical Detection
- Hormonal Regulation and Hypertension
- Antiplatelet Therapy and Cardiovascular Diseases
- Research in Social Sciences
Karolinska Institutet
2015-2024
Örebro University Hospital
2024
NU Hospital Group
2022-2023
Vårdcentralen Teleborg
2021
Stockholm South General Hospital
2017
Institute for Medical Informatics and Biostatistics
2015
Skanska (Sweden)
2004
Chalmers University of Technology
2000
Karolinska University Hospital
1982
To compare drug survival on adalimumab, etanercept and infliximab in patients with rheumatoid arthritis (RA).Patients RA (n=9139; 76% women; mean age 56 years) starting their first tumour necrosis factor (TNF) inhibitor between 2003 2011 were identified the Swedish Biologics Register (ARTIS). Data collected through 31 December 2011. Drug over up to 5 years of follow-up was compared overall by period treatment start (2003-2005/2006-2009; n=3168/4184) adjustment for age, sex, education,...
Abstract Unreliable predictions can occur when an artificial intelligence (AI) system is presented with data it has not been exposed to during training. We demonstrate the use of conformal prediction detect unreliable predictions, using histopathological diagnosis and grading prostate biopsies as example. digitized 7788 from 1192 men in STHLM3 diagnostic study, used for training, 3059 676 testing. With prediction, 1 794 (0.1%) incorrect cancer (compared 14 errors [2%] without prediction)...
Risk of basal cell carcinoma (BCC) has been reported to be several‐fold increased among organ transplant recipients (OTRs). However, due lack reliable BCC registration, population‐based risk estimates are scarce. To characterize OTRs compared with the general population, and contrast cutaneous squamous (SCC). transplanted during 2004–2011 were identified through national healthcare registers linked nationwide Swedish Register initialized in 2004. Relative was expressed as standardized...
Abstract The International Society of Urological Pathology (ISUP) hosts a reference image database supervised by experts with the purpose establishing an international standard in prostate cancer grading. Here, we aimed to identify areas grading difficulties and compare results those obtained from artificial intelligence system trained In series 87 needle biopsies cancers selected include problematic cases, failed reach 2/3 consensus 41.4% (36/87). Among non-consensus weighted kappa was 0.77...
Many patients with rectal cancer receive radiotherapy (RT) to reduce the risk of local recurrence. Radiation may give rise adverse effects, including second primary cancers. In view divergent results previous studies, present study evaluated following RT in all randomized trials conducted Sweden and Swedish ColoRectal Cancer Registry (SCRCR).Patients included five SCRCR were linked Registry. Cox regression models estimated hazard ratio (HR) among who received compared those did not.A total...
The objective of this study is to find clinical variables that predict the prognosis for men with castration-resistant prostate cancer (CRPC) in a Swedish real-life CRPC cohort, including risk group classification clarify succumbing cancer. This natural history cohort representing premodern drug era before introduction novel hormonal therapies.PSA tests from chemistry laboratories serving health care six regions Sweden were retrieved and cross-linked National Prostate Cancer Registry (NPCR)...
Background and objective Image-based artificial intelligence (AI) methods have shown high accuracy in prostate cancer (PCa) detection. Their impact on patient outcomes cost effectiveness comparison to human pathologists remains unknown. Our aim was evaluate the cost-effectiveness of AI-assisted pathology for PCa diagnosis Sweden. Methods We modeled quadrennial prostate-specific antigen (PSA) screening men between ages 50 74 yr over a lifetime horizon using health care perspective. Men with...
Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. We conducted a nested case–control study of ASA after diagnosis among women using Swedish National Registries. assessed prospectively recorded exposure during different time windows following conditional logistic regression death as the main outcome. Within each six-month period follow-up, we categorized dispensed doses into three groups: 0, less than 1, and 1 or more daily doses....
Background Bleeding risk stratification in acute coronary syndrome is of highest clinical interest but current scores have limitations. We sought to develop and validate a new in‐hospital bleeding score for patients with myocardial infarction. Methods Results From the nationwide SWEDEHEART (Swedish Web‐System Enhancement Development Evidence‐Based Care Heart Disease Evaluated According Recommended Therapies) register, 97,597 infarction enrolled from 2009 until 2014 were selected. A full...
Given the wide public health implications of melanoma epidemic, ultraviolet radiation (UVR) exposure patterns contributing to cutaneous development should be clearly identified. To describe time trends anatomic sites using a UVR model based on clothing and sun habits, we reviewed medical records all patients diagnosed with primary invasive or in situ (MIS) during years 1977-78, 1983-84, 1989-90, 1995-96, 2000-01 (n=3058) one healthcare region Sweden. Age-standardized incidence rates relative...
Summary Background Asthma is common in both children and adults the Western world, just like anxiety depression. While some research has revealed that these diseases might share important environmental pathophysiological aspects, exact mechanisms still remain unclear. Objective To study correlation firstly between depression or asthma diagnosis adult twins secondly association parental offspring of twins. Methods In total, 24 685 aged 20–47 years were interviewed completed a Web‐based...
<h3>Importance</h3> Diabetic men appear to have a lower risk of prostate cancer. Whether antidiabetic medications are protective or potentially mask cancer by lowering prostate-specific antigen (PSA) levels is unclear. <h3>Objective</h3> To examine the associations medication use with (1) PSA levels, (2) frequency testing, (3) receipt biopsy following elevated results, and (4) detection at biopsy. <h3>Design, Setting, Participants</h3> Population-based cohort study using data from Stockholm...
Active surveillance (AS) is increasingly utilized for low-risk prostate cancers, to delay or avoid treatment.To (1) describe uptake and intensity of real-world use AS compare with national guidelines, (2) transitions from conservative curative treatment by different indications disease progression.A population-based cohort study men diagnosed cancer, in Stockholm County, Sweden, during 2008-2017. Follow-up was up 10yr, a median 3.5yr.Poisson regression used estimate incidence rate ratios...
None of the authors have any conflicts interest.
There is strong evidence that cribriform morphology indicates a worse prognosis of prostatic adenocarcinoma. Our aim was to investigate its interobserver reproducibility in prostate needle biopsies.A panel nine pathology experts from five continents independently reviewed 304 digitised biopsies for cancer according recent International Society Urological Pathology criteria. The were collected series 702 by one the panellists enrichment high-grade and potentially structures. A 2/3 consensus...
Abstract Background In the future, we can expect an increase in older patients emergency departments (ED) and acute wards. The main purpose of this study was to identify predictors short- long-term mortality ED at hospital discharge. Methods This is a retrospective, observational, single-center, cohort study, involving critically ill adults, recruited consecutively ED. primary outcome mortality. All were followed for 6.5–7.5 years. Cox proportional hazards model used. Results Regarding all...
Active surveillance (AS) for men with low-risk prostate cancer (PC) can lead to patient morbidity and healthcare overutilization. The aim of this study was evaluate an AS protocol using the Stockholm3 test magnetic resonance imaging (MRI) reduce biopsy intensity.We conducted a prospective multicenter 280 invited from contemporary screening (STHLM3), Gleason Score (GS) 3 + PC on current protocol. Patients underwent prostate-MRI blood sampling analysis including protein biomarkers, genetic...