A5088014950- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Lanthanide and Transition Metal Complexes
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Electron Spin Resonance Studies
University of Lausanne
2017-2023
Purpose To implement a fluorine‐19 ( 19 F) chemical shift encoding (CSE) approach for the sensitive imaging of molecules with multi‐resonance spectra to remove their displacement (CSD) artifacts, and characterize its sensitivity versus established pulse sequences. Methods The feasibility CSE spoiled gradient echo (GRE) balanced steady‐state free precession (bSSFP) was first demonstrated in phantom study. dependence CSE‐bSSFP on several sequence parameters then established, after which...
Abstract Fluorine-19 ( 19 F) magnetic resonance imaging (MRI) of injected perfluorocarbons (PFCs) can be used for the quantification and monitoring inflammation in diseases such as atherosclerosis. To advance translation this technique to clinical setting, we aimed 1) demonstrate feasibility quantitative F MRI small foci on a scanner, 2) characterize PFC-incorporating leukocyte populations plaques. end, thirteen atherosclerotic apolipoprotein-E-knockout mice received 2 × 200 µL PFC, were...
The two main challenges that prevent the translation of fluorine-19 (19 F) MRI for inflammation monitoring or cell tracking into clinical practice are (i) relatively low signal-to-noise ratio generated by injected perfluorocarbon (PFC), which necessitates long scan times, and (ii) need regulatory approval a high biocompatibility PFCs also suitable MRI. ABL-101, an emulsion perfluoro(t-butylcyclohexane), is third-generation PFC already used in trials, but has not yet been 19 F objective this...
Fluorine-19 (19F) MRI of injected perfluorocarbon emulsions (PFCs) allows for the non-invasive quantification inflammation and cell tracking, but suffers from a low signal-to-noise ratio extended scan time. To address this limitation, we tested hypothesis that 19F pulse sequence combines specific undersampling regime with signal averaging has increased sensitivity robustness against motion artifacts compared to non-averaged fully-sampled dataset, when both are reconstructed compressed...
To investigate three MR pulse sequences under high-frequency noninvasive ventilation (HF-NIV) at 3 T and determine which one is better-suited to visualize the lung parenchyma.A 3D ultra-short echo time stack-of spirals Volumetric Interpolated Breath-hold Examination (UTE Spiral VIBE), without with prospective gating, a double-echo UTE sequence spiral phyllotaxis trajectory (3D radial UTE) were performed in ten healthy volunteers HF-NIV. Three experienced radiologists evaluated visibility...
Rationale and Objectives Computed tomography (CT) lung nodule assessment is routinely performed appears very promising for cancer screening. However, the radiation exposure through time remains a concern. With overall goal of an optimal management indeterminate nodules, objective this prospective study was therefore to evaluate potential optimized ultra-short echo (UTE) MRI detection volumetric assessment. Materials Methods Eight (54.9 ± 13.2 years) patients with at least 1 non-calcified ≥4...
Purpose To develop high‐spatial‐resolution cardiac T 2 mapping that allows for a reduced acquisition time while maintaining its precision. We implemented and optimized new golden‐angle radial technique named SKRATCH (Shared k‐space Radial Characterization of the Heart) shares peripheries ‐weighted images preserving their contrasts. Methods Six variants (gradient‐recalled echo balanced SSFP, free‐breathing breath‐held, with without saturation preparation) were implemented, precision was...
To evaluate the effect of lung stabilization using high-frequency non-invasive ventilation (HF-NIV) and breath-hold (BH) techniques on nodule detection texture assessment in PET/CT compared to a free-breathing (FB) standard CT acquisition PET/CT.Six patients aged 65 ± 7 years, addressed for initial at least one suspicious with 18F-FDG PET/CT, underwent three consecutive acquisitions FB, HF-NIV BH. Lung nodules were assessed all characterized any size, volume solid/sub-solid nature.BH...