A5101990909- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Acute Myeloid Leukemia Research
- Orthopedic Infections and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Surgical Sutures and Adhesives
- Mass Spectrometry Techniques and Applications
- Clinical practice guidelines implementation
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Research Studies
- Advanced Proteomics Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Cytokine Signaling Pathways and Interactions
- Tendon Structure and Treatment
- Brain Metastases and Treatment
- Virus-based gene therapy research
- Eosinophilic Disorders and Syndromes
- Hip and Femur Fractures
- CRISPR and Genetic Engineering
- Pharmaceutical Practices and Patient Outcomes
- Lipoproteins and Cardiovascular Health
Princess Margaret Cancer Centre
2014-2024
Sunnybrook Health Science Centre
2023-2024
Health Sciences Centre
2023-2024
Royal Liverpool University Hospital
2023
University of Liverpool
2023
University of Oxford
2010-2021
Brigham and Women's Hospital
2017-2021
Nuffield Orthopaedic Centre
2017-2020
University Health Network
2006-2018
Palmetto Hematology Oncology
2018
Unicompartmental knee replacement (UKR) has substantial benefits over total (TKR) but higher revision rates. The cementless Oxford UKR was introduced to address this there are concerns about fixation and tibial plateau fractures. first long-term study of the device with clinical radiographic outcomes is reported.The 1000 medial were prospectively identified followed up by independent physiotherapists. Survival calculated using endpoints reoperation, revision, TKR, major requiring TKR...
Some health providers ration knee arthroplasty on the basis of body mass index (BMI). There is no long-term data outcome medial mobile-bearing unicompartmental (UKA) in different BMI groups. This study aimed to determine effect patient (BMI) patient-reported outcomes and survival UKA a large non-registry cohort. Our hypothesis that increasing would be associated with worse outcomes.Data were analysed from prospective cohort 1000 consecutive Oxford mean 10-year follow-up. Patients grouped: <...
The purpose of this study was to understand why the revision rate unicompartmental knee replacement (UKR) in National Joint Registry (NJR) is so high. Using radiographs, appropriateness patient selection for primary surgery, surgical technique, and indications were determined. In addition, alignment radiographs assessed.Oxford UKR registered with NJR between 2006 2010 subsequently revised identified by NJR. A blinded review undertaken pre-primary, post-primary, pre-revision anteroposterior...
Aims To report mid- to long-term results of Oxford mobile bearing domed lateral unicompartmental knee arthroplasty (UKA), and determine the effect potential contraindications on outcome. Methods A total 325 consecutive UKAs undertaken for recommended indications were included, their functional survival outcomes assessed. The effects age, weight, activity, presence full-thickness erosions cartilage in patellofemoral joint outcome evaluated. Results Median follow-up was seven years (3 14),...
The validity of administrative data may be vulnerable to how well physicians document medical charts. objective this study is determine the relationship between chart documentation quality and data. charts for patients who underwent carotid endarterectomy were re-abstracted rated documentation. Poorly well-documented compared by patient, physician, hospital variables, as on agreement Of 2061 reviewed, 42.6 per cent documented. proportion documented varied from 14.6 87.5 across 17 hospitals,...
Abstract The complex inhomogeneous architecture of the human meniscal tissue at micro and nano scale in absence artefacts introduced by sample treatments has not yet been fully revealed. knowledge internal structure organization is essential to understand mechanical functionality meniscus its relationship with tissue’s structure. In this work, we investigated using up-to-date non-invasive imaging techniques, based on multiphoton fluorescence quantitative second harmonic generation microscopy...
Abstract Transformation of BCR::ABL1-negative myeloproliferative neoplasms (MPN) to an accelerated or blast phase is associated with poor outcomes. The efficacy acute myeloid leukemia (AML)–type intensive and nonintensive hypomethylating agent–based regimens not well studied. We therefore performed a retrospective analysis patients MPN-AP/BP (N = 138) treated 81) 57) blast-reduction strategies. used clinically relatable response criteria developed at the Princess Margaret Cancer Centre....
The meniscus is an integral part of the human knee, preventing joint degradation by distributing load from femoral condyles to tibial plateau. Recent qualitative studies suggested that constituted intricate net collagen channels inside which fluid flows during loading. aim this study describe in detail structure quantifying orientation and morphology meniscal tissue. A 7 mm cylindrical sample, extracted vertically central a lateral porcine was freeze-dried scanned using highest-to-date...
Activation of JAK2 by chromosomal translocation or point mutation is a recurrent event in hematopoietic malignancies, including acute leukemias and myeloproliferative disorders. Although the effects activated signaling have been examined cell lines murine models, functional consequences deregulated context human cells are currently unknown. Here we report that expression TEL-JAK2, constitutively active variant kinase, lineage-depleted umbilical cord blood results erythropoietin-independent...
Background: There is controversy about optimal limb alignment following knee replacement. An aim of using Oxford medial unicompartmental replacement (UKR) implants to accurately restore normal ligament tension in the knee, thereby restoring kinematics. This return typically results a prearthritic alignment, which frequently varus. The this study was investigate relationship between postoperative and patient-reported outcome implant revision rate. Methods: We used consecutive cohort 891 knees...
Abstract Background Osteoporosis and osteopenia are conditions characterised by reduced bone mineral density (BMD). There is concern that with BMD may not provide sufficient fixation for cementless components which primarily rely on the quality of surrounding bone. The aim our study was to report midterm clinical outcomes patients undergoing unicompartmental knee replacements (UKR). Our hypothesis there would be no difference in outcome between normal those BMD. Methods From a prospective...
The aim of this study was to determine the polyethylene wear rate Phase 3 Oxford Unicompartmental Knee Replacement bearings and investigate effects resin type manufacturing process.A total 63 patients with at least ten years' follow-up three bearing types (1900 machined, 1050 moulded) were recruited. Patients underwent full weight-bearing model-based radiostereometric analysis thickness. linear estimated from change in thickness divided by duration implantation.The for 1900 machined (n =...
Abstract Purpose Unicompartmental knee replacement (UKR) is widely considered to be a pre-total (TKR) particularly in the young. The implication of this that it sensible do UKR, even though will revised at some stage, as delay need for TKR. chance UKR being during patient’s life time has not previously been calculated. aim study was estimate lifetime revision risks patients different ages undergoing UKR. Methods Calculations were based on data from designer series 1000 medial Oxford with...