A5079535025- Advanced MRI Techniques and Applications
- NMR spectroscopy and applications
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Alzheimer's disease research and treatments
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- High-pressure geophysics and materials
- Solid-state spectroscopy and crystallography
- Rheology and Fluid Dynamics Studies
- Osteoarthritis Treatment and Mechanisms
- Diamond and Carbon-based Materials Research
- Medical Imaging Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Spectroscopy and Chemometric Analyses
- Nuclear Physics and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Fluid Dynamics and Mixing
- Ultrasound Imaging and Elastography
- Total Knee Arthroplasty Outcomes
- Photoacoustic and Ultrasonic Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
- Physiological and biochemical adaptations
- Ultrasound and Hyperthermia Applications
University of California, Davis
2013-2023
Resonance Research (United States)
2006-2021
UC Davis Comprehensive Cancer Center
2014-2020
University of Puget Sound
2014
The University of Texas at El Paso
2004
University of Maine
2003
Texas A&M University
1996
United States Naval Research Laboratory
1993-1995
Florida State University
1992-1994
National High Magnetic Field Laboratory
1994
Abstract The work includes development of a multiphase porous media model and magnetic resonance imaging (MRI) experiments to study microwave combination heating. Combination electromagnetic, convective radiant heating was considered. material being heated modeled as hygroscopic medium with different phases: solid matrix, water gas, included pressure driven flow, binary diffusion phase change. three‐dimensional transport fully coupled electromagnetics include the effect variable properties....
Cerebral edema forms in the early hours of ischemic stroke by processes involving increased transport Na and Cl from blood into brain across an intact blood–brain barrier (BBB). Our previous studies provided evidence that BBB Na–K–Cl cotransporter is stimulated factors hypoxia, aglycemia, arginine vasopressin (AVP), inhibition intravenous bumetanide greatly reduces infarct rats subjected to permanent middle cerebral artery occlusion (pMCAO). More recently, we showed Na/H exchanger activity...
A fundamental mechanistic understanding of the pressure- and/or temperature-induced facile transformation coordination environment boron is important for changing physical properties glass. We have used in situ high-pressure (up to 2 gigapascals) boron-11 solid-state nuclear magnetic resonance spectroscopy combination with ab initio calculations investigate nature transition state pressure-induced BO3→ BO4 conversion a borosilicate glass at ambient temperature. The results indicate an...
Abstract It is conventionally thought that multiplication of the xylem-limited bacterium Xylella fastidiosa (Xf) within xylem vessels sole factor responsible for blockage water movement in grapevines (Vitis vinifera) affected by Pierce's disease. However, results from our studies have provided substantial support idea vessel obstructions, and likely other aspects disease syndrome, result grapevine's active responses to presence Xf, rather than direct action bacterium. The use magnetic...
Abstract Impairment of vascular pathways cerebral β-amyloid (Aβ) elimination contributes to Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we show in human tissues and AD-model rats that bloodborne islet amyloid polypeptide (amylin) secreted from the pancreas perturbs Aβ clearance. Blood amylin concentrations are higher AD than cognitively unaffected persons. Amyloid-forming accumulates circulating monocytes co-deposits within brain microvasculature,...
Abstract Articular cartilage is a load bearing and lubricating tissue in animal joints. Heterogeneous deformations arise the structured zonal under application of mechanical load. The character these altered by degenerative joint disease. Here, we document an MRI‐based technique for determining throughout volume based on displacement encoding with stimulated echoes (DENSE) fast spin echo (FSE) readout. A DENSE‐FSE was designed to image at 9.4 Tesla deformed state during cyclic loading....
While Magnetic Resonance Thermometry (MRT) has been extensively utilized for non-invasive temperature measurement, there is limited data on the use of high field (≥7T) scanners this purpose. MR-guided Focused Ultrasound (MRgFUS) a promising method localized hyperthermia and drug delivery. MRT based sensitivity proton resonance frequency (PRF) implemented in both tissue phantom vivo mouse Met-1 tumor model, using partial parallel imaging (PPI) to speed acquisition. An MRgFUS system capable...
Dynamic Nuclear Polarization (DNP) is a powerful suite of techniques that deliver multifold signal enhancements in nuclear magnetic resonance (NMR) and MRI. The generated athermal spin states can also be exploited for quantum sensing as probes many-body physics. Typical DNP methods require the use cryogens, large fields, high power microwave excitation, which are expensive unwieldy. Nanodiamond particles, rich Nitrogen-Vacancy (NV) centers, have attracted attention alternative agents because...
Nanoparticle-based theranostic agents have emerged as a new paradigm in nanomedicine field for integration of multimodal imaging and therapeutic functions within single platform. However, the clinical translation these is severely limited by complexity fabrication, long-term toxicity materials, unfavorable biodistributions. Here we report an extremely simple robust approach to develop highly versatile biocompatible poly(vinyl alcohol)-porphyrin nanoparticles (PPNs). Through "one-pot"...
A positron emission tomography (PET) system or 'insert' has been constructed for placement and operation in the bore of a small animal magnetic resonance imaging (MRI) scanner to allow simultaneous MR PET imaging. The insert contains electronics, components with variety properties large continuous sheets metal—all characteristics an object that should, by conventional wisdom, never be placed scanner, especially near volume. There are ways two systems might expected interact could negatively...
A double-tuned NMR microprobe with dual RF microcoil assemblies was fabricated and tested. The coils for the proton X (low frequency) nuclei were a variant of loop gap resonator Helmholtz pair, respectively. 1-D 31P spectra phosphoric acid 13C-labeled methanol recorded from 1.4-μL samples. Signal easily observable in one scan. COSY spectrum acetic acquired ∼1 h, demonstrating sufficient sensitivity to perform 2-D 13C direct detect experiments. Thus, ability obtain detection low-γ is demonstrated.
Abstract The miscibility of two‐component polymer blends has been investigated using xenon‐129 ( 129 Xe) nuclear magnetic resonance (NMR) to probe the phase morphology. chemical shift Xe dissolved in a given is unique, thus heterogeneous with large domain sizes exhibit two NMR lines. When single obtained, data are consistent miscibility, yielding an upper bound on size. temperature dependence relative solubilities and shifts pure components may allow determination morphology exhibiting...
Articular cartilage provides critical load-bearing and tribological properties to the normal function of diarthrodial joints. The unique cartilage, as well heterogeneous deformations during mechanical compression, are due nonuniform microstructural organization tissue components such collagens proteoglycans. A new deformation by tag registration (CDTR) technique has been developed authors determine in articular explants. uses a combination specialized MRI methods, custom cyclic loading...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNMR chemical shift of xenon-129 dissolved in polymersJ. B. Miller, J. H. Walton, and C. M. RolandCite this: Macromolecules 1993, 26, 21, 5602–5610Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://doi.org/10.1021/ma00073a011RIGHTS & PERMISSIONSArticle Views185Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads...
Abstract Articular cartilage is critical to the normal function of diarthrodial joints. Despite importance tissue and prevalence degeneration (e.g., osteoarthritis), technology required noninvasively describe nonuniform deformations throughout volume has not been available until recently. The objectives work reported in this paper were 1) a noninvasive technique (termed deformation by tag registration (CDTR) technique) determine articular explants with use specialized MRI tagging image...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrostatic pressure dependence of molecular motions in polycarbonatesJ. H. Walton, Martin J. Lizak, Mark S. Conradi, Terry Gullion, and Jacob SchaeferCite this: Macromolecules 1990, 23, 2, 416–422Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://doi.org/10.1021/ma00204a011RIGHTS & PERMISSIONSArticle Views108Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are...
Significance We report on progress toward combining magnetic resonance imaging (MRI) and optical in diamond microparticles. Our approach relies the nitrogen vacancy (NV) center-driven nuclear hyperpolarizability particles, that renders them “bright” MRI while simultaneously fluorescing optically. Both modes allow suppression of background signals. elucidate how such “dual-mode” can perform better than either taken separately, leveraging relative strengths optics with respect to resolution...