Background: Nephrolithiasis is a kidney disorder caused by the formation of crystals through physiological and chemical processes in body, with calcium oxalate being major contributor. Moringa oleifera leaves are known for their antioxidant, diuretic, anti-inflammatory properties, containing alkaloids, flavonoids, polyphenols, polysaccharides, saponins, phenolics, tannins. Aim: This study aimed to investigate potential leaf extract (MLE) as crystal inhibitor, its effect on reducing...

Background: Lead intoxication triggers testicular toxicity via oxidative stress. Aim: This study aimed to explore the antioxidant potential of Moringa oleifera leaf extract (MOLE) in enhancing semen quality rats exposed lead acetate. Methods: Twenty-five healthy were randomly and equally divided into five groups. Group C served as negative control, whereas group C+ was acetate at 50 mg/kg body weight (BW)/day without MOLE. The T1, T2, T3 groups BW concurrently received MOLE doses 200, 316,...

Lead intoxication triggers testicular toxicity via oxidative stress. This study aimed to explore the antioxidant potential of Moringa oleifera leaf extract (MOLE) in enhancing semen quality rats exposed lead acetate. Twenty-five healthy were randomly and equally divided into five groups. Group C served as negative control, whereas group C+ was acetate at 50-mg/kg body weight (BW)/day without MOLE. The T1, T2, T3 groups BW concurrently received MOLE doses 200-, 316-, 500-mg/kg BW/day,...

Background: Breast cancer affects women at various ages, and its recurrence is a significant cause of death. The search for potent anticancer compounds herbal origin with well-defined mechanisms action an essential focus current research. Aim: This study aimed to investigate the effects alkaloids in Achyranthes aspera Linn (AAL) leaf extract on necrosis, apoptosis, related molecular markers, namely, cyclin-dependent kinase 1, Bcl-2 associated X-protein (Bax), rat sarcoma virus (Ras),...

Penelitian ini bertujuan untuk membuktikan ekstrak buah pare (Momordica charantia Linn.) terhadap kadar glukosa darah, sel penyusun pulau Langerhans dan Leydig tikus putih (Rattus norvegicus) hiperglikemia. Tikus sebanyak 25 ekor dibagi secara acak menjadi 5 kelompok. Induksi aloksan dengan dosis 150 mg/kgbb intraperitoneal menimbulkan kerusakan pankreas dilakukan pada kelompok perlakuan. Tiga perlakuan diterapi berbagai pare, (P1) 29 mg/1ml/hari, (P2) 50 (P3) 59 satu sebagai kontrol negatif...

Since the damage to alveolar tissue due cigarette smoke exposure (CSE) is lipid peroxidation, antioxidant treatment needed. The red guava (Psidium guajava L.) fruit contains antioxidants derived from quercetin, lycopene, and vitamin C. This study aimed determine effect of extract (RGFE) on rats exposed smoke. 25 (Rattus norvegicus) were divided into five groups. control T0 groups only administered placebo, while T1, T2, T3 orally RGFE 18.9, 37.8, 56.7 mg/kg body weight daily for 44 days. CSE...

Diabetes mellitus is a chronic condition defined by elevated blood sugar levels (hyperglycemia). This can lead to complications such as nephropathy, which histologically shown with glomerulosclerosis. Glucomannan, component of Amorphophallus muelleri , offers numerous health benefits, but its direct therapeutic effect on glomeruli remains uncertain. Male Wistar rats were taken random sampling ( n = 30) distributed into six distinct groups. All groups, excluding Group N, received 125 mg/kg BW...

This study aims to determine the α-tocopherol effect on repairing histological damage testicles of rats exposed 2,3,7,8-tetrachlorodibenzo-p-dioxin. The testicle and repairs were evaluated based spermatogenic staging changes, seminiferous tubule diameter thickness epithelium. A total 100 divided into five groups. control group (CG) only received a placebo. Meanwhile, in treatment groups, dioxin 700 ng/kg/BW/day four hours later they 0, 77, 140 259 mg/kg/BW/day T0, T1, T2 T3 respectively....

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent organic pollutant that induces overproduction of reactive oxygen species (ROS). Studies on avoiding the adverse effects dioxin pollution exposure are needed in all aspects, including reproductive health. This study aimed to determine effect α-tocopherol superoxide dismutase (SOD) and malondialdehyde (MDA) levels, live spermatozoa, apoptosis, necrosis male rats exposed as model. Thirty healthy 12-week-old were randomly divided into...

Latar belakang: Pencemaran plastik menjadi isu kesehatan saat ini. Partikel berukuran mikron (MPs) dapat mengganggu karena terkonsumsi secara tidak sengaja oleh mahluk hidup dan masuk kedalam rantai makanan manusia. Polietilena salah satu polimer yang banyak mengkontaminasi terabsorbsi akan mengalami persisten bioakumulasi dalam darah. ini mengandung bahan toksik sehingga menimbulkan reaksi oksidasi pada komponen biologi, satunya low-density lipoprotein (LDL). Ox-LDL menyebabkan kerusakan...

Abstract Preclinical studies for discovering and developing a drug disease involve utilizing animals as experimental subjects. The search an effective efficient murine model of dengue virus (DENV) infection is ongoing to support further scientific updates. This study aimed explore the suitability Wistar rats DENV infection. Twenty-four (male sex, 2-3 months old, 200-300 grams weight) were randomly divided into four groups (n=6 per group): control group (no infection), SC-Group (DENV-2 s.c.),...

Background of the Problem: In 2000, deaths caused by air pollution in world reached 57,000 people per year and it is estimated that over next 20 years this figure will increase to close 14% or 0.7 year. According Calvin, 2020, Gold Mining, incidents Silica exposure among workers aged 45-55 out 2255 people, was found 1592 (71%) died. From number above, there were 1296 (81%) suffering from silicosis pulmonary Tuberculosis (TB). Chemical dust (Silica) causes lung disorders, which one...

Dengue infection has become one of the most important mosquito-borne diseases worldwide and is caused by dengue virus (DENV). Recently, neither patent drug, phytopharmaceutical medicine, nor standardized herbal medicine been officially available against DENV. Dried red jujube fruit (Ziziphus jujuba) ethanol extract proven to have an antiviral effect, anti-inflammatory efficacy, antioxidant properties, which potential activity DENV infection. This research was conducted analyze dried DENV-2...

Background: The LD50 (lethal dose causing 50% mortality) of ethylene glycol (EG) and its associated toxicity in mice (Mus musculus) were assessed by evaluating kidney function. Aim: This study aimed to determine the acute oral lethal (LD50) glycol, also degeneration, necrosis, inflammatory cell invasion tubules male rats (Rattus norvegicus) as animal model. Methods: There 66 DDG (Deutschland Denken Yoken) 11 groups six this investigation. daylong metabolic cage contained one control (C) ten...

The Regional Leading Product Development Program (RLPDP) activities are carried out to sustain the existence of Micro, Small, and Medium Enterprises (MSMEs) processed marine products in increasing marketing new normal Covid-19 Pandemic period. This makes implementation team assist strategies used by MSMEs effectiveness these strategies. In this activity, factors influencing MSMEs’ sustainability were product innovation, packaging, marketing. method was education, training, mentoring for...

Background: Coronavirus 2019 (COVID-19) is a global pandemic with various clinical manifestations and affected by multifactor. Epidemiological data of COVID-19 in Indonesia, especially Surabaya have not been well established yet. Purpose: This study aims to provide the patients profile City, Indonesia. Method: The were retrospectively collected from electrical medical records Primasatya Husada Citra (PHC) Hospital Surabaya, one referral hospitals for Surabaya. Descriptive Spearman...

Aims: To analyze the effect of severity long COVID syndrome on quality life COVID-19 survivors at age 15-64 years old.
 Study Design: Cross-sectional observational study.
 Place and Duration Study: Gotong Royong Hospital, Surabaya, Indonesia between July to September 2022
 Methodology: This study uses a cross-sectional design. The number samples used was 67 respondents who had been hospitalized Surabaya during acute infection. sampling technique in this simple purposive...

Rapid oxygen desaturation has been widely reported in sufferers of Coronavirus Disease (COVID-19) with severe and critical severity. The latest scientific evidence shows that this virus can interact erythrocytes disrupt the function hemoglobin as an transporter. This study aims to analyze relationship between erythrocyte index severity COVID-19 sufferers. research is a cross-sectional 120 confirmed at PHC Surabaya hospital. was conducted from January 2021 July 2021. data collected electronic...

The SARS-CoV-2 pandemic has a very high daily mortality rate. Rapid spread and worsening of clinical manifestations need early intervention. Systemic inflammation in COVID-19 can cause multi-organ damage, thus one markers, Neutrophil Lymphocyte Ratio (NLR) be used as an predictive factor for COVID-19. Liver is the organs affected by COVID-19, which seen from increased Alanine Transaminase (ALT) Aspartate (AST). This study aims to analyze correlation between NLR, ALT, AST with disease...

The Covid-19 pandemic had a big impact on the world over past two years., and it is estimated that 1 in 10 people have been infected. development of prevention treatment systems can reduce mortality, but new problem has emerged group survivors. New clinical complaints, Getting COVID-19 again or having ongoing symptoms for four weeks after first infection, affect wide variety organ functions. long-term effects COVID-19, like feeling tired, trouble breathing, chest pain, difficulty thinking,...