A5031533421- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- biodegradable polymer synthesis and properties
- Dental materials and restorations
- Dental Research and COVID-19
- Bone Tissue Engineering Materials
- Analytical Methods in Pharmaceuticals
- Antimicrobial agents and applications
- Dental Erosion and Treatment
- Dental Implant Techniques and Outcomes
- Pharmacological Effects of Natural Compounds
- Organoselenium and organotellurium chemistry
- Bee Products Chemical Analysis
- Pain Mechanisms and Treatments
- Microencapsulation and Drying Processes
- Phytochemicals and Antioxidant Activities
- Analytical Chemistry and Chromatography
- Dermatology and Skin Diseases
- Essential Oils and Antimicrobial Activity
- Skin Protection and Aging
- Endodontics and Root Canal Treatments
- Crystallization and Solubility Studies
- Periodontal Regeneration and Treatments
- Phytochemistry Medicinal Plant Applications
Universidade Estadual de Ponta Grossa
2014-2024
Universidade Federal do Paraná
2015-2016
Skin aging causes changes such as wrinkles and flaccidity leading to a large demand for aesthetic procedures, including dermal filling. A key agent in filling is hyaluronic acid (HA), which naturally occurring glycosaminoglycan. However, it hydrophilic macromolecule that experiences great difficulty crossing the skin barrier causing most commercial formulations containing be injectable, turn brings risks since they involve an invasive technique. In sense, aim of this study was develop...
This study investigated the resin–dentin bond strength (μTBS), degree of conversion (DC), and antibacterial potential an innovative adhesive system containing a quaternary ammonium methacrylate polymer (QAMP) using in situ vitro assays. Forty-two human third molars were flattened until dentin was exposed randomly distributed into three groups self-etching systems: Clearfil™ SE Bond 5% QAMP (experimental group), Protect (positive control) (negative control). After light curing, 1...
Background: As part of the efforts to find natural alternatives for cancer treatment and overcome barriers cellular resistance chemotherapeutic agents, polymeric nanocapsules containing curcumin and/or methotrexate were prepared by an interfacial deposition preformed polymer method. Methods: Physicochemical properties, drug release experiments in vitro cytotoxicity these performed against Calu-3 lung cell line. Results: The colloidal suspensions showed suitable size (287 325 nm), negative...
A simple stability-indicating HPLC-DAD method was validated for the determination of ferulic acid (FA) in polymeric microparticles. Chromatographic conditions consisted a RP C 18 column (250 mm × 4.60 mm, 5 μ m, 110 Å) using mixture methanol and water pH 3.0 (48 : 52 v/v) as mobile phase at flow rate 1.0 mL/min with UV detection 320 nm. The developed per ICH guidelines respect to specificity, linearity, limit quantification, detection, accuracy, precision, robustness provided suitable...
A quaternary ammonium methacrylate polymer (QAMP) with antimicrobial potential was synthesized. The resulting product characterized by FTIR spectroscopy, NMR visible spectrophotometry, XRPD and TGA. in vitro susceptibility tests against Streptococcus mutans of QAMP were investigated prior after incorporation into a commercial adhesive system (Clearfil™ SE Bond). release compounds from the experimental Bond + 5% QAMP) performed during 1, 7, 14, 21 30 days. Spectroscopic data confirmed that...
This article aimed to improve the relative solubility and dissolution rate of ferulic acid (FA) by use spray-dried solid dispersions (SDs) in order ensure its vitro antioxidant potential enhance vivo anti-platelet effect. These SDs were prepared spray-drying at 10 20% drug concentration using polyvinylpyrrolidone K30 (PVP-K30), polyethylene glycol 6000 (PEG 6000) poloxamer-188 (PLX-188) as carriers. physical mixtures (PM) characterized SEM, XRPD, FTIR spectroscopy TGA analysis. Spray-dried...
The objective of this research was to synthetize a hydroxyapatite-capsaicin composite (HAp-CAP) and assess its physicochemical properties for potential use in an in-office dental bleaching gel. HAp-CAP nanocomposite prepared by the precipitation method using 4:1 ratio nano-hydroxyapatite (nano-HAp) capsaicin (CAP) dissolved 99.5% ethyl alcohol (q.s.p) with assistance zirconia beads SpeedMixer®. Characterization involved morphological, spectroscopic, thermal analyses. Subsequently,...
Adapalene (ADAP) is an important drug widely used in the topical treatment of acne. It a third-generation retinoid and provides keratolytic, anti-inflammatory, antiseborrhoic action. However, some adverse effects such as erythema, dryness, scaling have been reported with its commercial formula. In this sense, microencapsulation using polyesters can circumvent side lead to enhancement delivery into sebaceous glands. The goal work was obtain ADAP-loaded poly(ε-caprolactone) (PCL)...
ABSTRACT Objectives: to analyze the diagnostic criteria for ventilator-associated pneumonia recommended by Brazilian Health Regulatory Agency and National Healthcare Safety Network/Centers Disease Control Prevention, as well its risk factors. Methods: retrospective cohort study carried out in an intensive care unit throughout 12 months, 2017. Analyses included chi-square, simple linear regression, Kappa statistical tests were conducted using Stata software. Results: sample was 543 patients...
Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application the often causes adverse side effects some patients. Hence, nanoencapsulation could be as an improved novel therapy mitigate and enhance bioavailability drug.Physicochemical properties, vitro release experiments, vivo anti-inflammatory activity studies were performed.TAC-loaded nanocapsules successfully prepared by interfacial deposition preformed...
Freeze- and spray-dried inclusion complexes (ICs) of chlorhexidine (CHX) in β-cyclodextrin were characterized by Fourier transform (FT)-Raman, 1H nuclear magnetic resonance (NMR), photoacoustic spectroscopy. The active Raman modes CHX simulated using the density functional theory. By considering semiempirical calculations, it was observed that guest penetrates on wider rim host a proportion 1:2. We observe from FT-Raman analysis drying method influences CHX:β-cyclodextrin conformational...
In this study, the preparation and characterization of three hydroxyapatite-based bioactive scaffolds, including hydroxyapatite microspheres (HAps), amoxicillin-hydroxyapatite composite (Amx-HAp), collagen-hydroxyapatite (Col-HAp) were performed. addition, their behavior in human dental pulp mesenchymal stem cell (hDPSC) culture was investigated. HAps synthesized through following methods: microwave hydrothermal, hydrothermal reactor, precipitation, respectively. hDPSCs obtained from samples...
The objective of this triple-blind, split-mouth, randomized clinical trial was to evaluate the bleaching efficacy and tooth sensitivity an in-office agent submitted different storage temperatures (room temperature at 21.04°C±3.13°C or refrigeration 5°C).Thirty volunteers were selected who had central incisors with color A2 higher. volunteers' maxillary hemi-arches received either treatment room refrigerated (two sessions 3×15 minutes, one-week interval). Color variation evaluated by...
The aim of this study was to synthetize a hydroxyapatite-capsaicin composite (HAp-CAP) and evaluate its physicochemical data for further use in hydrogen peroxide in-office dental bleaching gel. HAp-CAP prepared by the precipitation method, performed 4:1 ratio using 3.2 g nano-hydroxyapatite (nano-HAp) 0.8 capsaicin (CAP) 99.5% ethyl alcohol (q.s.p) zirconia beads at SpeedMixer®. characterized morphological, spectroscopic, thermal analyses. In following, added an test effect on reducing...