A5021421440- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Actinomycetales infections and treatment
- Metastasis and carcinoma case studies
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Diagnosis and treatment of tuberculosis
- Healthcare Systems and Public Health
- Legal and Regulatory Analysis
- Construction Management and Sustainability
- Diverticular Disease and Complications
- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders Research
- Infective Endocarditis Diagnosis and Management
- Regional Socio-Economic Development Trends
- Global trade, sustainability, and social impact
- Intensive Care Unit Cognitive Disorders
- Blood disorders and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infectious Disease Case Reports and Treatments
- Sepsis Diagnosis and Treatment
- Parasitic Diseases Research and Treatment
North-Western State Medical University named after I.I. Mechnikov
2019-2025
Ministry of Health of the Russian Federation
2024
Saint Petersburg State Pediatric Medical University
2023
Volgograd State Technical University
2019
Introduction. Systemic immune-inflammatory diseases can affect many systems and organs have an extremely severe course with complications, causing multiple organ failure death. Often, children such require hospitalization in the intensive care unit (ICU). For example, approximately 50% of patients multisystem inflammatory syndrome, associated COVID-19 (MIS-C) systemic lupus erythematosus ICU. The objective was to determine risk factors for lethal outcome hospitalized Materials methods....
We studied the risk factors, etiology, clinical features and effectiveness of therapy COVID-19-associated pulmonary aspergillosis (CAPA) in adult patients. In this retrospective study, we included 45 patients with proven (7%) probable (93%) CAPA. The ECMM/ISHAM, 2020 criteria were used to diagnose A case-control study was conducted factors CAPA; control group 90 COVID-19 without IA. CAPA patients, main underlying diseases diabetes mellitus (33%), hematological oncological (31%). probability...
Primary immune deficiencies are usually attributed to genetic defects and, therefore, frequently referred as inborn errors of immunity (IEI). We subjected the genomic DNA 333 patients with clinical signs IEI next generation sequencing (NGS) analysis 344 immunity-related genes in some instances, additional techniques. Genetic causes disease were identified 69/333 (21%) subjects, including 11/18 (61%) children syndrome-associated IEIs, 45/202 (22%) nonsyndromic Jeffrey Modell Foundation (JMF)...
We studied the risk factors, etiology, clinical manifestations, and treatment outcomes of COVID-19-associated invasive candidiasis (COVID-IC) in adult patients admitted to six medical facilities St. Petersburg. (November 2020–December 2022). In this retrospective study, we included 72 with COVID-IC a median age 61 years (range 29–96), 51% whom were women. The predisposing factors for central venous catheter (CVC) more than 10 days (the odds ratio (OR) = 70 [15–309]), abdominal surgical...
Actinomycosis is a chronic bacterial infection caused by bacteria from the Actinomycetaceae family. The causes of abdominal actinomycosis are usually destructive appendicitis, prolonged presence an intrauterine contraceptive or perforation colon. Of internal organs, left colon and sigmoid most often affected, which leads to surgical complications. At same time, diagnosis significantly difficult due nonspecific nature clinical presentation, similar that oncological diseases, verification...
Invasive fungal infections (IFIs) are a serious threat to patients with hematological diseases. These characterized by high mortality and lead significant financial costs for treatment. The most common pathogens of IFIs Aspergillus spp. Candida spp., but in recent years, cases caused rare have become more frequent. Diagnosis choice treatment remain challenging due the nonspecificity symptoms diversity clinical cases. In this regard, problem start time antifungal therapy remains current...
Mucormycosis is a severe mycotic infection with high mortality among immunocompromised patients. Its in- cidence in solid organ transplant recipients 2–8% of all invasive fungal infections. In most cases, it occurs the late posttransplant period. Risk factors this patient cohort are graft-versus-host disease (GvHD) and use immunosuppressive drugs. The article describes clinical cases mucormycosis analysis literature data on problem recipients. It also reviews main methods diagnosis treatment...
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Introduction . In children with rheumatic diseases, severe fungal infections (invasive mycoses – IM) are not well understood. Objectives To analyze risk factors, disease course of IM in systemic diseases. Materials and methods For diagnosis were used criteria EORTC/MSGERC, 2019. We reviewed the literature over past 15 years on diseases from international databases Pubmed Web Science. Results retrospective multicenter study included 8 diseases: ANCA-associated vasculitis (n=4), lupus...
Abstract The purpose of this article is finding ways increasing habitat sustainability in residential areas the first mass series. According to results carried out studies on basis calculated assessment development with 5-storey brick buildings series 1-447 city Volgograd, following main conclusions are formulated. Before increase sustainability, construction area have class E (S-factor equal 209 points). After a grade expected rise level C 341 Systematization and synthesis data “green”...
Objective. To study risk factors, clinical and radiological features effectiveness of the treatment invasive aspergillosis (IA) in adult patients with COVID-19 (COVID-IA) intensive care units (ICU). Materials Methods. A total 60 COVID-IA treated ICU (median age 62 years, male – 58%) were included this multicenter prospective study. The comparison group 34 outside 68%). ECMM/ISHAM 2020 criteria used for diagnosis CAPA, EORTC/MSGERC evaluation efficacy. case-control (one patient main per two...
РУБРИКА ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ Синдром хронического кандидоза кожи и слизистых у детей с мутациями гена STAT 1 Федеральное государственное бюджетное образовательное учреждение высшего образования «Северо-Западный государственный медицинский университет имени И.И.Мечникова» Министерства здравоохранения Российской Федерации, 191015, г.Санкт-Петербург, Российская Федерация 2 «Санкт-Петербургский педиатрический университет» 194100, г
We present a case of fungal peritonitis in patient secondary to intestinal perforation and repeated laparotomy. An analysis data from the register patients with invasive candidiasis is also presented. In study were included 42 candida peritonitis. The risk factors: antibiotics (100%), vascular catheters (95%), total parenteral nutrition (81%), abdominal surgery (69%), sepsis bacteremia (50%), perforations on gastrointestinal tract (43%), oncopathology (36%), infected pancreatic necrosis...
<p>The article considers the current state of insurance market in Kemerovo region, as well trends affecting market. In crisis year 2015, Russia and region was developing due to growth compulsory life insurance, whereas classical saw a decline. Comparative analysis showed preferential development optional medical third party car regional The features an structure portfolio companies, place role companies region. Regional organizations specialize voluntary health which reflects specifics...
Objectives. Actinomycosis in children has not been studied enough, the number of publications is limited. knee joint very rare, disease mimics tuberculosis or malignant neoplasms, which can lead to late diagnosis and inadequate treatment. Materials methods. We report on first case an 8-year-girl with actinomycosis knee. Diagnosis based histological examination. Results. Surgical resection infected tissue longterm antibiotic therapy for 4.5 months was effective treatment pediatric patient...
The prevalence of invasive candidiasis (IC) in pediatric hospitals is from 4,3 to 15,2 per 10,000 hospitalized, ICU – 3,5 7 cases 1,000, with HSCT 2,9%. average length stay a patient the hospital before development IC varies 21 56 days, more than 15 days. Knowledge risk factors (ICU for ≥15 use antibacterial drugs and parenteral nutrition, active malignant neoplasm, etc.) makes it possible identify patients high (10-46%) developing IC. Candida albicans remains leading causative agent...