A5072639341- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Adenosine and Purinergic Signaling
- Gene Regulatory Network Analysis
- Autism Spectrum Disorder Research
- Neuropeptides and Animal Physiology
- Forensic Toxicology and Drug Analysis
Florida Atlantic University
2018-2025
Disruptions of dopamine (DA) signaling contribute to a broad spectrum neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), addiction, bipolar disorder, and schizophrenia. Despite evidence that risk for these disorders derives from heritable variation in DA-linked genes, better understanding is needed the molecular circuit context through which gene drives distinct disease traits. Previously, we identified DA transporter (DAT) variant Val559 subjects with...
Abstract Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms depression and anxiety-related disorders, e.g., social phobias post-traumatic stress disorder. Recent evidence from preclinical clinical studies established therapeutic potential drugs inducing release 5-HT via 5-HT-transporter. Nevertheless, current releasing compounds under investigation carry risk for abuse deleterious side effects. Here, we demonstrate that S -enantiomers certain...
Dopamine (DA) signaling dysfunction is believed to contribute multiple neuropsychiatric disorders including attention-deficit/hyperactivity disorder (ADHD). The rare DA transporter (DAT) coding substitution Ala559Val found in subjects with ADHD, bipolar and autism, promotes anomalous efflux vitro and, DAT Val559 mice, leads increased reactivity imminent handling, waiting impulsivity, enhanced motivation for reward. Here, we report that, contrast amphetamine methylphenidate, which induce...
The antidepressant-sensitive serotonin (5-HT) transporter (SERT) dictates rapid, high-affinity clearance of the neurotransmitter in both brain and periphery. In a study families with multiple individuals diagnosed autism spectrum disorder (ASD), we previously identified several, rare, missense coding variants that impart elevated 5-HT transport activity, relative to wild-type SERT, upon heterologous expression as well ASD subject lymphoblasts. most common these variants, SERT Ala56, located...
Abstract Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD), autism spectrum (ASD), substance use disorder, and attention-deficit/hyperactivity (ADHD). Treatment of these disorders remains inadequate, as exemplified by the therapeutic d-amphetamine methylphenidate for treatment ADHD, agents with high abuse liability. In search an improved non-addictive approach DA-linked disorders, we utilized a preclinical mouse model expressing human DA transporter...
Abstract Virtually all neuropsychiatric disorders display sex differences in prevalence, age of onset, and/or clinical symptomology. In sex-biased disorders, one is often suggested to harbor protective mechanisms, rendering them resilient genetic environmental risk factors. Here, we demonstrate molecular, pharmacological and behavioral effects induced by the dopamine (DA) transporter (DAT) coding variant Ala559Val, previously identified subjects diagnosed with male-biased...