A5059544679- Mesenchymal stem cell research
- Liver physiology and pathology
- Tissue Engineering and Regenerative Medicine
- Organ Transplantation Techniques and Outcomes
- Extracellular vesicles in disease
- Pancreatitis Pathology and Treatment
- Silk-based biomaterials and applications
- Congenital Diaphragmatic Hernia Studies
- Collagen: Extraction and Characterization
- Pancreatic and Hepatic Oncology Research
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
Institute of Molecular Biology and Genetics
2020-2023
National Scientific Center "M.D. Strazhesko Institute of Cardiology"
2023
National Academy of Sciences of Ukraine
2022
Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine
2020-2022
Collagen and its derivates are typically obtained by extracting them from fresh animal tissues. Lately, however, there has been an increased interest in obtaining collagen other sources, such as waste material, because of the growing trend to replace synthetic materials with sustainable, natural counterparts various industries, well ensure a rational revalorization. In this paper, was non-tanned leather production, taken at different stages production process: limed pelt, delimed fleshings....
Pancreatitis is a disease characterized by an acute or chronic inflammatory process of the pancreas, induced activation trypsin inside acinocytes. These processes result in necrosis organ's parenchyma, abscess formation, and systemic complications, contributing to patient mortality rates ranging from 30-47%. As now, there no globally recognized effective treatment for pancreatitis. Multipotent mesenchymal stem cells (MMSCs) are potential candidates treating this due their immunomodulatory...
Mesenchymal stem cells (MSCs) have unique properties that ensure the regeneration of damaged tissues, which allows using them in cell therapy various diseases.The realization these is mainly related to interaction MSCs with macrophages.Aim.To study human umbilical cord macrophages vivo a model sterile inflammation peritoneal cavity mice.Methods.Cytological methods for assessing acute mice, isolation and cultivation MSCs, expression MSC surface markers by flow cytometry, determination...
Abstract Mesenchymal stem cells are the most promising regenerative medicine tool for treatment of various diseases, including liver disease, although exact mechanism their therapeutic action remains unclear. It was found that MSCs captured by lungs after systemic transplantation, quickly disappear, and not detected at site injury, but same time exhibit an obvious effect. Comparison MSC efficiency depending on route administration may shed light mechanisms involved in implementation...
Mesenchymal stem cells are the most promising regenerative medicine tool for treating various diseases, including liver disease, although exact mechanism of their therapeutic action remains unclear. It was found that MSCs captured by lungs after systemic transplantation, quickly disappear, and not detected at site injury but same time exhibit an obvious effect. Comparison MSC efficiency depending on route administration may shed light mechanisms involved in implementing potential. In this...
Aim. To study the process of recovery rat liver in a model cirrhosis, which was induced by intraperitoneal injection CCl4, after transplantation human umbilical cord MSCs. Today world as an alternative to is offered cell therapy, leads organ’s functions through The key role MSCs development fibrosis and its final stage - cirrhosis inhibitory effect on proliferation extracellular matrix. Methods. methods histology morphometry were used work. Results. It found, that 13 weeks CCl4 induction,...
Aim.The study aims to determine the effects of transplantation preconditioned human umbilical cord mesenchymal stem cells (hUC-MSC) seeded on a biomimetic 3D scaffold.Methods.Porous collagen scaffolds were prepared by freeze-drying type I solutions.hUC-MSC isolated explant method.The hUC-MSC with H 2 O or LPS for 24 hours, and onto scaffolds.The MSC preconditioning studied xenogenic model.The five days after implantation analyzed histologically PCRbased detection human-specific sequences in...