A5078429145- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Advanced Radiotherapy Techniques
- Blood donation and transfusion practices
- Acute Lymphoblastic Leukemia research
- Pancreatic and Hepatic Oncology Research
- Testicular diseases and treatments
- Autopsy Techniques and Outcomes
- Educational Curriculum and Learning Methods
- Ocular Oncology and Treatments
- Full-Duplex Wireless Communications
- interferon and immune responses
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Bipolar Disorder and Treatment
- Parvovirus B19 Infection Studies
- Bone health and osteoporosis research
- Liver physiology and pathology
- Acute Kidney Injury Research
- Cancer Genomics and Diagnostics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Myeloid Leukemia Research
University of Indonesia
2018-2024
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2018-2024
Thalassaemia is one of the most prevalent inherited blood disorders in Indonesia, with highly diverse mutations ranging from mild to severe that can be found across nation. Nevertheless, thalassaemia management Indonesia still limited supportive treatment, such as transfusion, iron chelation, complications monitoring, psychosocial support and a comfortable transition child adult clinic. However, these managements are suboptimal parts has long way implementing optimal curative treatment for...
Background Routine blood transfusions and increased intestinal iron absorption lead to accumulation in various organs, especially the liver. To date, T2-star magnetic resonance imaging (T2*MRI) is a valuable tool evaluate level organs.
 Objective assess degree of liver overload among children with thalassemia major (TM) its possible correlations hepatic function laboratory values.
 Methods This cross-sectional study was conducted Cipto Mangunkusumo Hospital. The evaluated by...
Background: Hemoglobin disorders such as thalassemia major have created an economic burden on the health care system. Iron chelation therapy (ICT) is most expensive cost component in patients with thalassemia. ICT was administered to reduce toxic effects of iron overload. This study aims compare costs chelators monotherapy Indonesia, specifically Cipto Faculty Medicine, Universit. Methods: a retrospective analytical observational study. Data were collected from registry 2016 2019. Patients’...
Abstract BACKGROUND To enhance the quality of care available for children with central nervous system (CNS) tumors across world, a systematic evaluation service delivery capacity is needed to identify gaps in pediatric neuro-oncology and prioritize interventions. that end, we created PediAtric Neuro-Oncology Resource AssesMent Aid (PANORAMA) tool. METHODS PANORAMA development consisted three phases: operationalization, consensus building, piloting. was designed have domains capture elements...
Abstract BACKGROUND Most children with central nervous system (CNS) tumors reside in LMICs, yet their complex management is limited by the availability of trained pediatric neuro-oncologists (PNO). The St. Jude Global VPNOF was designed to train oncologists (PO) LMICs as CNS tumor experts while remaining home countries. METHODS structure initially developed through semi-structured interviews physicians who had served global mentors or mentees oncology. Employing a modified Delphi method, we...
Abstract Background To enhance the quality of care available for children with central nervous system (CNS) tumors across world, a systematic evaluation capacity is needed to identify gaps and prioritize interventions. that end, we created pediatric neuro-oncology (PNO) resource assessment aid (PANORAMA) tool. Methods The development PANORAMA encompassed 3 phases: operationalization, consensus building, piloting. aimed capture elements PNO continuum through domains weighted assessments...
Abstract BACKGROUNDS Gliomas are the most common form of pediatric brain tumor. The primary obstacle to optimizing tumor health services, particularly in LMICs, is lack comprehensive epidemiological data. We aim compile data on gliomas, focusing clinical profiles and outcomes within a national general hospital Indonesia. METHODS A retrospective observational longitudinal study was performed at Cipto Mangunkusumo National General Hospital, glioma patients’ outcomes, registered under CNS...
Abstract BACKGROUND Systematic documentation and research on pediatric brain tumor (PBT) have been underreported in Indonesia. Precise readily available epidemiological data hold significant value enhancing the PBT service of any center, each with its own distinctive characteristics. We aim to evaluate our registry after Cipto Mangunkusumo National General Hospital utilized St. Jude (SJ) Cares Registry program. METHODS A retrospective observational longitudinal study, carried out at...
Abstract INTRODUCTION Subependymal giant cell astrocytoma (SEGA) represents a rare type of brain tumor that predominantly manifests in individuals with tuberous sclerosis complex (TSC), genetic disorder characterized by the growth benign tumors various organs. In radiology, SEGA exhibits distinct imaging characteristics modalities such as magnetic resonance (MRI) and computed tomography (CT). Radiological features include well-defined intraventricular masses variable enhancement patterns...
Abstract BACKGROUNDS Pediatric brain tumors (PBT) exhibit extensive heterogeneity, impacting treatment outcomes. While traditionally classified based on histopathological features, recent WHO classifications have integrated DNA methylation array profiling amongst other molecular characteristics, which improves diagnostic accuracy and thus decisions. However, access to this technology is limited in low- middle-income countries (LMICs) like Indonesia. As part of the MNP Outreach Consortium, we...
Abstract BACKGROUND Medulloblastoma is the most frequent malignant brain tumor in children and adolescents, accounting for 20–25% of all tumors. Epidemiological data fundamental to optimising pediatric (PBT) health services reducing overall morbidity mortality. To bridge this gap, we aimed present comprehensive medulloblastoma data, focusing on clinical profiles outcomes within one national general hospitals country. METHODS A retrospective observational longitudinal study was conducted at...
Abstract Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a sporadic and highly malignant that usually affects very young children typically deadly despite aggressive treatment. The optimal treatment for AT/RT remains unclear, including surgery, radiotherapy, chemotherapy. Here we report cases in Indonesia. Case 1: A three-year-old girl came with worsening intermittent headaches projectile vomiting, progressive insidious right spastic hemiparesis, slowly weight loss...
Abstract Diffuse Intrinsic Pontine Gliomas (DIPG) is a rare and highly aggressive central nervous system tumour arising from glial cells which occur mostly in children. It remains potentially deadly cancer despite treatment, with the highest mortality rate, most children die within 1-year of diagnosis. Radiation therapy might improve clinical symptoms, but results are temporary, tumor progression typically occurring months post radiation, whereas chemotherapy controversial. Here we present...
Introduction: Thalassemia is the most common hemoglobinopathy in Indonesia. Chronic anemia, iron overload, and treatment with chelating agents are factors that contribute to kidney dysfunction children transfusion-dependent thalassemia (TDT). Urine neutrophil gelatinase-associated lipocalin (uNGAL) urine albumin-creatinine ratio (uACR) markers of glomerular tubular damage. Objectives: To analyze glomerulotubular function TDT children. Patients Methods: This prospective cohort study recruited...
BACKGROUND: Organ damage due to iron toxicity is one factor that increases the risk of getting cardiovascular and metabolic diseases in thalassemia patient. This study aims determine glucose lipid profiles adolescents with major its association overload pancreas liver.METHODS: was a cross sectional study. Subjects were without any confounding factors may affect levels. Blood samples collected measure level, profiles, ferritin level transferrin saturation. T2-Magnetic Resonance Imaging used...
Abstract Methotrexate (MTX) is an essential component of chemotherapy for childhood acute lymphoblastic leukemia (ALL). Both intravenous (IV) and most commonly intrathecal (IT) routes MTX have been complicated in acute, subacute, chronic neurotoxicity syndromes. A 9-year-old girl had diagnosed with standard risk ALL since 2011 first protocol was Indonesian 2006 remission 2012. On July 2015, patient as relapse underwent high 2013. The last 2013 maintenance phase 89th weeks total dosage 336 mg...
Abstract BACKGROUND Optic nerve infiltration in acute lymphoblastic leukemia is a rare manifestation. This may appear months advance as an isolated sign of extramedullary relapse and considered one the significant clinical findings central nervous system leukemia. AIM: To describe case rapidly progressive optic girl with ALL remission. CASE: A 13-year-old full remission following treatment for B-cell presented decreased vision proptosis on left eye. She completed chemotherapy course two...
Abstract Retinoblastoma is the most common primary malignant intraocular cancer that usually develops in early childhood. About 5% of those patients are at risk developing trilateral retinoblastoma (TRB). In countries, them came late stage; therefore, ocular and patient survival rates lower than developed countries. From 2015–2019, we found four cases retinoblastoma. Two had bilateral retinoblastoma, two unilateral They all presented with leukocoria no family history The mean age was 13.8...
Background: Thalassemia major has various complications that can increase morbidity and mortality. Osteoporosis is a common complication in thalassemia multifactorial pathogenesis. cause vertebral compression fractures lead to disability. In TIF recommendation, DEXA-scan used measure bone density patients. However, most patients Indonesia could not afford the examination because it covered by insurance. The 2019 ISCD Pediatric Positions Task Forces stated diagnosis of pediatric osteoporosis...
Abstract INTRODUCTION: Tuberous sclerosis complex (TSC) is an autosomal-dominant genetic disorder causing the formation of hamartomas in many organs, including brain. It generally benign but can block flow cerebrospinal fluid that increases intracranial pressure and leads to severe neurologic behavioural changes. Subependymal giant cell astrocytoma (SEGA) occurs 10-15% TSC patients. Routine brain surveillance important look for SEGA all CASE: We report a girl who was previously diagnosed...
Transfusion-dependent thalassemia is the most severe form of thalassemia; patients require regular blood transfusions to maintain their hemoglobin level. The COVID-19 pandemic has disrupted routine measures for controlling chronic diseases like thalassemia. This study aims measure difference in pre-transfusion levels and frequency before during pandemic. retrospective cross-sectional utilized medical record data 101 transfusion-dependent (TDT) treated Cipto Mangunkusumo Hospital (CMH) from...