A5017212378- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Genetics and Neurodevelopmental Disorders
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- RNA regulation and disease
- Neurotransmitter Receptor Influence on Behavior
- Biochemical effects in animals
- Stress Responses and Cortisol
- Lipid Membrane Structure and Behavior
National Institute of Mental Health
2016-2023
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2022
Czech Academy of Sciences, Institute of Physiology
2009-2016
Czech Academy of Sciences
2009-2014
Charles University
2009
Synthetic cannabinoid compounds are marketed as "legal" marijuana substitutes, even though little is known about their behavioral effects in relation to pharmacokinetic profiles. Therefore, the present study we assessed of systemic treatment with two synthetic cannabinoids JWH-073 and JWH-210 phytocannabinoid Δ9-THC on locomotor activity, anxiety-like phenotype (in open field) sensorimotor gating (measured prepulse inhibition acoustic startle response, PPI), serum levels. Wistar rats were...
The activation of metabotropic glutamate receptors subtype 4 (mGluR4) potentiates models absence seizures in adult rats. These are age-dependent, but data concerning the role mGluR4 immature brain is insufficient. N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1acarboxamide (PHCCC), which a positive allosteric modulator these receptors, was used three different rats: 1) convulsions induced by high doses pentetrazol (PTZ; model generalised tonic-clonic seizures); 2) rhythmic...
Abstract Formation and consolidation of memories for highly stressful (traumatic) events is a complex process that involves interplay between multiple memory systems has implications etiology treatment stress- trauma-related disorders. Here we study effects sleep/wake state high intra-hippocampal corticosterone on aversive contextual as well association simple cues fear response in rats. Animals were implanted with EEG EMG electrodes sleep assessment cannulas application. They familiarized...