A5011431222- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Lung Cancer Treatments and Mutations
- Airway Management and Intubation Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nosocomial Infections in ICU
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Tuberous Sclerosis Complex Research
- Neuroscience of respiration and sleep
- Economic and Financial Impacts of Cancer
- Obstructive Sleep Apnea Research
- COVID-19 Clinical Research Studies
- Vascular Anomalies and Treatments
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Therapeutic Uses of Natural Elements
- Sarcoidosis and Beryllium Toxicity Research
- Extracellular vesicles in disease
- Polyomavirus and related diseases
- Autoimmune and Inflammatory Disorders
Azienda USL di Bologna
2021-2024
University of Bologna
2019-2024
Policlinico S.Orsola-Malpighi
2019-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2021
University Hospital of Bern
2019
University of Bern
2019
University of Pisa
2017-2018
Azienda Ospedaliera Universitaria Pisana
2016
High flow nasal cannula (HFNC) is used to treat acute hypoxemic respiratory failure (AHRF) even outside the ICU and ROX index (pulse oximetry/fraction of inspired oxygen/respiratory rate) may predict HFNC failure. The purpose this investigation was therefore verify whether an accurate predictor for COVID-19 patients treated intensive care unit (ICU) evaluate validity previously suggested threshold. Multicenter study. Retrospective observational analysis prospectively collected data. 3...
This retrospective cohort study was conducted in two teaching hospitals over a 3-month period (March 2010-June 2020) comparing severe and critical COVID-19 patients admitted to Respiratory Intensive Care Unit for non-invasive respiratory support (NRS) subjected awake prone position (PP) with those receiving standard care (SC). Primary outcome endotracheal intubation (ETI) rate. In-hospital mortality, time ETI, tracheostomy, length of RICU hospital stay served as secondary outcomes. Risk...
Up to fifteen percent of patients with novel pandemic coronavirus disease (Covid-19) have acute respiratory failure (ARF). Ratio between arterial partial pressure oxygen (PaO2) and fraction inspired (FiO2), P/F, is currently used as a marker ARF severity in Covid-19. P/F does not reflect the efforts made by maintain blood oxygenation, such tachypnea hyperpnea, leading hypocapnia. Standard PaO2, value PaO2 adjusted for carbon dioxide (PaCO2) subject, better reflects pathophysiology hypoxemic...
Persistent hypercapnia after COPD exacerbation is associated with excess mortality and early rehospitalization. High Flow Nasal cannula (HFNC), may be theoretically an alternative to long-term noninvasive ventilation (NIV), since physiological studies have shown a reduction in PaCO2 level few hours of treatment. In this clinical study we assessed the acceptability HFNC its effectiveness reducing patients recovering from Acute Hypercapnic Respiratory Failure (AHRF) episode. We also...
<b><i>Background:</i></b> Few studies have reported a double-step follow-up of patients after hospitalization for COVID-19. <b><i>Objectives:</i></b> We designed an observational study with clinical, functional, and radiological evaluation at 2 6 months The primary outcome was to describe symptoms, spirometry, 6-minute walking test (6MWT) months. Secondary outcomes were identify if the lowest...
The present study describes the case of a 45-year-old man diagnosed with metastatic lung adenocarcinoma, which harbored deletion within exon 19 epidermal growth factor receptor (EGFR) gene. patient was subsequently treated gefitinib (250 mg/day orally from May 2013 to March 2014), but developed acquired resistance drug following 11 months treatment. Tumor burden molecular analysis performed on tumor rebiopsy and plasma sample, histological also rebiopsy. A small cell transformation retaining...
Worldwide there is an imbalance between the number of patients discharged after Covid-19 and availability healthcare resources to follow them acute illness. Six-minute walking test (6MWT) a valid inexpensive measure exercise capacity for people with chronic lung disease. We used 6MWT during follow-up verify if it can be reliable disease recovery. During we reported distance in meters (6MWD), lowest SpO2 when breathing air (SpO2 nadir), desaturation distance–saturation product (DSP), defined...
Interstitial lung diseases (ILDs) encompass a heterogeneous group of parenchymal disorders which have significant burden on quality life and exercise. The primary purpose this randomised pilot trial performed in advanced ILD was to determine the feasibility efficacy multidisciplinary palliative care approach (including physiotherapist, psychologist, pulmonologists, doctors) relieve patients' symptoms dyspnoea, depression measured with Center for Epidemiological Studies-Depression (CES-D)...
Nasal high flow (NHF) therapy is an established form of non invasive respiratory support used in acute and chronic care. Recently, a new nasal cannula with asymmetric prongs was approved for clinical use. The benefits the have not yet been defined no evidence are available on use NHF patient Chronic Obstructive Pulmonary Disease (COPD). We conducted single-centre, prospective, physiologic, crossover, randomised study to investigate effects partial pressure carbon dioxide (PaCO2) levels two...
3067 Background: Nivolumab is the first checkpoint inhibitor approved for treatment of squamous non small cell lung cancer (Sq-NSCLC) to show a survival benefit in randomised phase III trial. The experience patients and physicians routine clinical practice often different from those controlled trial setting. purpose this analysis evaluate nivolumab use real world Methods: was available upon physician request (pts) aged ≥ 18 years who had relapsed after minimum one prior systemic stage...
Abstract This 68-year-old woman with a 9-year history of skin sarcoidosis presented abdominal pain, bloating, and diarrhea. Following positive occult fecal blood, diagnosis ascending colon was pathologically confirmed after colonoscopy. FDG PET/CT performed for sarcoid staging, the demonstrated only focal site active (SUVmax = 10).
<b><i>Background:</i></b> Assessment of intrinsic dynamic positive end-expiratory pressure (PEEPi,dyn) may be clinically important in stable patients with chronic obstructive pulmonary disease (COPD), but epidemiological data are scant. <b><i>Objectives:</i></b> The aim our study was (i) to assess the PEEPi,dyn a large population COPD and (ii) evaluate correlations some noninvasive measurements routinely assessed....
Postoperative pain and persisting fatigue represent critical concerns for patients receiving lung transplantation. The purpose of this study was to illustrate the trajectory symptoms in a patient who presented with posttransplant musculoskeletal syndrome after double redo-lung transplantation attended therapeutic sessions global postural re-education during symptomatic phase. A 32-year-old woman interstitial disease underwent At 23 months, functional parameters deteriorated, placed on active...
Background/Aims Although an increasing volume of research is emerging, rehabilitative treatment patients with COVID-19 still continues to be a matter great importance that must explored further. The purpose the present study was describe effects inpatient rehabilitation in acute treated sub-intensive hospital setting during pandemic. Methods A retrospective analysis conducted based on prospectively collected data 192 undergoing physiotherapeutic regimen their hospitalisation. Patients were...
Multiple organ failure has been considered a contraindication for noninvasive ventilation (NIV).We described the outcome of Do-not-Intubate (DNI) patients with acute respiratory failure, treated NIV and, subsequently, necessitating renal replacement therapy (RRT).Seven admitted to our Respiratory Intensive Care Unit, developed Acute Kidney Injury (AKI) during treatment and received RRT 12.8 ± 8 days together NIV. All but one, discontinued support because they regained satisfactory urinary...