A5070200212- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Photodynamic Therapy Research Studies
- DNA Repair Mechanisms
- HER2/EGFR in Cancer Research
- Advanced biosensing and bioanalysis techniques
- Fatty Acid Research and Health
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Biochemical and Molecular Research
- Intraperitoneal and Appendiceal Malignancies
- Cancer Treatment and Pharmacology
- Click Chemistry and Applications
- Cancer Research and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Birth, Development, and Health
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
UPMC Hillman Cancer Center
2016-2025
Jilin University
2014-2020
Jinzhong University
2019-2020
Peking University Shougang Hospital
2018
University of Pittsburgh
2002-2016
Tianjin University of Science and Technology
2010-2011
Central Arkansas Veterans Healthcare System
2004
University of Arkansas for Medical Sciences
2004
National Cancer Institute
2004
Grace (United States)
2003
The purpose of this phase II study was to evaluate hyperthermic intraperitoneal chemotherapy (HIPEC) with carboplatin for recurrent ovarian cancer during secondary cytoreductive surgery.Patients were intraoperatively randomly assigned HIPEC (800 mg/m2 90 minutes) or no HIPEC, followed by five six cycles postoperative IV carboplatin-based chemotherapy, respectively. Based on a binomial single-stage pick-the-winner design, an arm considered winner if ≥ 17 49 patients without disease...
The c-Myc oncoprotein is overexpressed in many tumors and essential for maintaining the proliferation of transformed cells. To function as a transcription factor, must dimerize with Max via basic helix-loop-helix leucine zipper protein (bHLH-ZIP) domains each protein. small molecule 7-nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine (10074-G5) binds to distorts bHLH-ZIP domain c-Myc, thereby inhibiting c-Myc/Max heterodimer formation its transcriptional activity. We report vitro...
Abstract Purpose: The primary objective was to establish the dose-limiting toxicity (DLT) and recommended phase II dose of 17-(allylamino)-17-demethoxygeldanamycin (17AAG) given twice a week. Experimental Design: Escalating doses 17AAG were i.v. cohorts three six patients. Dose levels for schedule A (twice weekly × 3 weeks, every 4 weeks) 100, 125, 150, 175, 200 mg/m2 B 2 200, 250 mg/m2. Peripheral blood mononuclear cells (PBMC) collected assessment heat shock protein (HSP) 90 HSP90 client...
Abstract New targeted chemotherapeutics are urgently needed to minimize off-target toxicity and reduce the high-mortality rate associated with metastatic prostate cancer. Herein, we report on modular synthesis, pharmacokinetics, efficacy of two small-molecule–drug conjugates (SMDC) prostate-specific membrane antigen (PSMA) incorporating either: (i) a cathepsin-B–cleavable valine–citrulline (Val–Cit), or (ii) an acid-cleavable phosphoramidate linker. Crucial components used in design include:...
The crystal structure of human class alpha glutathione (GSH) S-transferase A3-3 (hGSTA3-3) in complex with GSH was determined at 2.4 Å. Despite considerable amino acid sequence identity other GSTs (e.g., hGSTA1-1), hGSTA3-3 is unique due to its exceptionally high steroid double bond isomerase activity for the transformation Δ5-androstene-3,17-dione (Δ5-AD) Δ4-androstene-3,17-dione. A comparative analysis active centers hGSTA1-1 and reveals that residues positions 12 208 may contribute their...
Although many cancer cells have significantly higher copper concentrations compared with normal and tissues, the role of in biology metastatic disease remains poorly understood. Here, we study importance osteosarcoma, which frequently metastasizes to lungs is often chemoresistant. K12 K7M2 are murine OS differing phenotypes: highly metastatic, whereas much less so. Intracellular levels were determined using atomic absorption. Copper transporters quantified by qPCR. Cytotoxicity doxorubicin,...
Cervical cancer is the second most common in women worldwide [1]. Photodynamic therapy has been used for cervical intraepithelial neoplasia with good responses, but few studies have newer phototherapeutics. We evaluated effectiveness of photodynamic using Pc 4 vitro and vivo against human cells.CaSki ME-180 cells were grown as monolayers spheroids. Cell growth cytotoxicity measured a methylthiazol tetrazolium assay. cellular uptake intracellular distrubtion determined. For irradiated at...
Aldehyde dehydrogenase 1A1 (ALDH) is a cancer stem cell marker highly expressed in metastatic cells. Disulfiram (Dis) an FDA-approved antialcoholism drug that inhibits ALDH and has been studied as candidate for repurposing multiple neoplasia. Dis cytotoxicity cells shown to be copper-dependent, part due Dis's ability function bivalent metal ion chelator of copper (Cu). The objectives this research were test expression levels Cu concentrations sarcoma patient tumors human osteosarcoma (OS)...
The present study describes the cDNA cloning, expression and characterization of a novel Mu class murine glutathione transferase (GST) isoenzyme. Screening library from small intestine female A/J mouse using consensus probes derived GST genes (mGSTM1-mGSTM5) resulted in isolation full-length clone previously unknown gene (designated as mGSTM7). choice tissue was based on our previous identification potentially deduced amino acid sequence mGSTM7, which comprises 218 residues, exhibited about...
Abstract Purpose: Interaction of 17-allylamino-17-demethoxygeldanamycin (17-AAG) with heat shock protein 90 results in proteasomal degradation many proteins, including Her-2-neu, subsequent decreased expression insulin-like growth factor binding protein-2 (IGFBP-2). Concentrations both IGFBP-2 and Her-2 extracellular domain (Her-2 ECD) sera mice bearing BT474 human breast cancer xenografts decrease after 17-AAG treatment. We investigated whether this phenomenon occurred patients. Materials...
Victims of a radiation terrorist event will include pregnant women and unborn fetuses. Mitochondrial dysfunction oxidative stress are key pathogenic factors fetal injury. The goal this preclinical study is to investigate the efficacy mitigating injury by maternal administration mitochondrial-targeted gramicidin S (GS)-nitroxide mitigator JP4-039. Pregnant female C57BL/6NTac mice received 3 Gy total-body irradiation (TBI) at mid-gestation embryonic day 13.5 (E13.5). Using novel...
The ability to noninvasively measure photosensitizer concentration at target tissues will allow optimization of photodynamic therapy (PDT) and could improve outcome. In this study, we evaluated whether preirradiation tumor phthalocyanine 4 (Pc 4) concentrations, measured by the optical pharmacokinetic system (OPS), correlated with response PDT. Mice bearing human breast cancer xenografts were treated 2 mg kg(-1) Pc iv only, laser irradiation (150 J cm(-2)) followed fractionated or continuous...
ABSTRACT Victims of a radiation terrorist event will include pregnant women and unborn fetuses. Mitochondrial dysfunction oxidative stress are key pathogenic factors fetal irradiation injury. The goal this preclinical study is to investigate the efficacy mitigating injury by maternal administration mitochondrial-targeted gramicidin S (GS)- nitroxide mitigator, JP4-039. Pregnant female C57BL/6NTac mice received 3 Gy total body ionizing (TBI) at mid-gestation embryonic day 13.5 (E13.5). Using...