A5088572511- CRISPR and Genetic Engineering
- Psychiatric care and mental health services
- Virus-based gene therapy research
- Healthcare Decision-Making and Restraints
- CAR-T cell therapy research
- Facial Nerve Paralysis Treatment and Research
- Healthcare Policy and Management
- Mental Health and Patient Involvement
- Primary Care and Health Outcomes
- Cytomegalovirus and herpesvirus research
- Education and Technology Integration
- Child and Adolescent Health
- Ear Surgery and Otitis Media
- Geriatric Care and Nursing Homes
- Schizophrenia research and treatment
- Employment and Welfare Studies
- Healthcare innovation and challenges
- Healthcare Systems and Challenges
- Collaborative Teaching and Inclusion
- Workplace Health and Well-being
- Health and Medical Research Impacts
- Salivary Gland Tumors Diagnosis and Treatment
- Intergenerational Family Dynamics and Caregiving
- LGBTQ Health, Identity, and Policy
- Sleep and related disorders
Bar-Ilan University
2020-2023
Institute of Nanotechnology
2023
Sheba Medical Center
2023
Edmond and Lily Safra Children's Hospital
2023
Foundation Center
2023
Belfast Metropolitan College
2022
Western University
2017-2020
Oxford Health NHS Foundation Trust
2009-2010
Buckinghamshire Healthcare NHS Trust
2008-2009
Wycombe General Hospital
1999-2003
Severe combined immunodeficiency (SCID) is a group of disorders caused by mutations in genes involved the process lymphocyte maturation and function. CRISPR-Cas9 gene editing patient's own hematopoietic stem progenitor cells (HSPCs)
The temporal bone is a part of the lateral skull surface that contains organs responsible for hearing and balance. Mastering surgery challenging because this complex microscopic three-dimensional anatomy. Segmentation intra-temporal anatomy based on computed tomography (CT) images necessary applications such as surgical training rehearsal, amongst others. However, segmentation due to similar intensities complicated anatomical relationships among critical structures, undetectable small...
Abstract Controlling off-target editing activity is one of the central challenges in making CRISPR technology accurate and applicable medical practice. Current algorithms for analyzing do not provide statistical quantification, are sufficiently sensitive separating signal from noise experiments with low rates, address detection translocations. Here we present CRISPECTOR, a software tool that supports quantification on- genome-editing NGS data using paired treatment/control experiments. In...
CRISPR-Cas technology has revolutionized gene editing, but concerns remain due to its propensity for off-target interactions. This, combined with genotoxicity related both CRISPR-Cas9-induced double-strand breaks and transgene delivery, poses a significant liability clinical genome-editing applications. Current best practice is optimize parameters in preclinical studies. However, quantitative tools that measure interactions are costly time-consuming, limiting the practicality of screening...
Abstract RAG2 -SCID is a primary immunodeficiency caused by mutations in Recombination-activating gene 2 (RAG2) , intimately involved the process of lymphocyte maturation and function. ex-vivo manipulation patient’s own hematopoietic stem progenitor cells (HSPCs) using CRISPR-Cas9/rAAV6 editing could provide therapeutic alternative to only current treatment, allogeneic cell transplantation (HSCT). Here we show an innovative correction strategy that replaces entire endogenous coding sequence...
The primary objective of this study was to use high-resolution micro-CT images create accurate three-dimensional (3D) models several intratemporal structures, and compare surgically important dimensions within the temporal bone. secondary a statistical shape model (SSM) dominant non-dominant sigmoid sinus (SS) provide template for automated segmentation algorithms.A free image processing software, 3D Slicer, utilized reconstructions SS, jugular bulb (JB), facial nerve (FN), external auditory...
Energy and stimulant drinks which contain caffeine provide enlivening effects, reduce fatigue improve concentration endurance. However, consumers may also experience physical psychological side effects as a result of excessive consumption within these drinks. Caffeine is known to exacerbate or induce some psychiatric conditions such anxiety, panic attacks, psychosis mania. Here we discuss case acute suicidality following sleep deprivation after the popular energy drink. We are concerned that...
Hypothesis: To characterize anatomical measurements and shape variation of the facial nerve within temporal bone, to create statistical models (SSMs) enhance knowledge bone anatomy aid in automated segmentation. Background: The is a fundamental structure otologic surgery, detailed anatomic with surgical experience are needed avoid its iatrogenic injury. Trainees can use simulators practice techniques, however manual segmentation required develop simulations be time consuming. Consequently,...
The incudostapedial joint (ISJ) of the middle ear is important for proper transmission sound energy to cochlea. Recently, biomechanics ISJ have been investigated using finite-element (FE) modelling, simplified geometry. objective present study was investigate feasibility synchrotron-radiation phase-contrast imaging (SR-PCI) in visualising ultrastructure. Three human cadaveric ISJs were dissected and scanned SR-PCI at 0.9 µm isotropic voxel size. One samples previously 9 images visually...
Aims and Method Buckinghamshire crisis home treatment team was struggling to meet its commissioned care episodes found itself detached from community mental health teams (CMHTs) acute day hospitals. An operations management consultant, using ‘lean’ principles developed in industry, worked alongside staff redesign the service. Results Improvements capacity ability contributed more reduced ward-stay times, compensating for impact of a ward closure. Re-examination individuals needs through...
Aims and Method To ascertain employers' attitudes to interviewing hiring job applicants with a history of mental illness and, in particular, assess the potential effect on prospects for admission under Mental Health Act 1983. A postal tick-box questionnaire was sent 174 companies; there 32% response rate. Results The main factors influencing decisions were medical opinion regarding an applicant's fitness work their employment sickness records. In about three-quarters small companies half...
Aims and Method To ascertain employers' attitudes to interviewing hiring job applicants with a history of mental illness and, in particular, assess the potential effect on prospects for admission under Mental Health Act 1983. A postal tick-box questionnaire was sent 174 companies; there 32% response rate. Results The main factors influencing decisions were medical opinion regarding an applicant's fitness work their employment sickness records. In about three-quarters small companies half...
Abstract RAG2 -SCID is a primary immunodeficiency caused by mutations in Recombination-activating gene 2 (RAG2) , intimately involved the process of lymphocyte maturation and function. ex-vivo manipulation patient’s own hematopoietic stem progenitor cells (HSPCs) using CRISPR-Cas9/rAAV6 editing could provide therapeutic alternative to only current treatment, allogeneic cell transplantation (HSCT). Here we show first-of-its-kind correction strategy that replaces entire endogenous coding...
Abstract The clinical problem of whether to stop antidepressants when patients develop mania is looked at in the light existing practice and advice both UK USA. It concluded that based more on an empirical than a scientific basis. literature subject reviewed with especial reference questions actually cause mania, they interfere treatment discontinuing them stops withdrawal causes mania. Finally case notes study conducted by one authors summarized recommendations for further research are made.
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It is common for people with low mood to drink alcohol excess, thus setting up a cycle of worsening depression. well recognised that antidepressants are not stand-alone treatment and concurrent help the patient reduce or stop drinking also required. This article describes how nalmefene, relatively new drug which helps comsumption, was used effectively in woman
A new breed of community practitioner is reaching out to people with dementia who might otherwise be missed, says Daniel Allen
Confusion, uncertainty and controversy: not words usually associated with a central plank of health policy. But according to report from the RCN, those are key characteristics continuing care for older people, which, since welfare state was established, has been subject intense disagreement.
Summary Although psychiatrists in England and Wales are generally familiar with the Mental Health Act 1983 Capacity 2005, there is a body of law that available to assist patients community which they less familiar. There two main reasons for this. The first it rather confused amalgam different statutes case affecting each other ways than clear. care programme approach (CPA) was meant cut through all this make provision straightforward. In fact, latter has never been always sat uneasily...