A5051489255- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Conducting polymers and applications
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Advanced Sensor and Energy Harvesting Materials
- Organic Electronics and Photovoltaics
- Tumors and Oncological Cases
- Neuroscience and Neural Engineering
- Semiconductor materials and interfaces
- Semiconductor materials and devices
- Renal cell carcinoma treatment
- Molecular Junctions and Nanostructures
- Luminescence Properties of Advanced Materials
- Plant Diversity and Evolution
- Reproductive Biology and Fertility
- Evolution and Paleontology Studies
- Bone Tumor Diagnosis and Treatments
- Nanowire Synthesis and Applications
- Renal and related cancers
- Genomics and Phylogenetic Studies
- Chalcogenide Semiconductor Thin Films
- Soft tissue tumors and treatment
- solar cell performance optimization
University of California, San Diego
2022-2024
Colorado School of Mines
2017-2023
California Institute of Technology
2016
National University of Singapore
1999
Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue without approved treatments. Download a PDF of the Research Summary. We conducted phase 3, international, double-blind, randomized, placebo-controlled trial nirogacestat in adults with progressing desmoid according to Response Evaluation Criteria Solid Tumors, version 1.1. Patients were assigned 1:1 ratio receive oral γ-secretase inhibitor (150 mg) or placebo twice daily. The primary end point was progression-free...
For a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) film employed in device stack, charge must pass through both the bulk of and interfaces between adjacent layers. Thus, transport is governed by contact resistances. However, for ultrathin films (e.g., flexible devices, thin-film transistors, printed electronics, solar cells), interfacial properties can dominate over properties, making resistance significant determinant performance. most applications, conductivity...
Abstract Durable and conductive interfaces that enable chronic high‐resolution recording of neural activity are essential for understanding treating neurodegenerative disorders. These implants require long‐term stability small contact areas. Consequently, they often coated with a blend polymers crosslinked to enhance durability despite the potentially deleterious effect crosslinking on mechanical electrical properties. Here grafting poly(3,4 ethylenedioxythiophene) scaffold,...
Functionalization of semiconductor surfaces with organic moieties can change the charge distribution, surface dipole, and electric field at interface. The modified will shift band-edge positions relative to those a contacting phase. Achieving chemical control over energetics promises provide means tuning form optimized junctions desired material. Si(111) functionalized 3,4,5-trifluorophenylacetylenyl (TFPA) groups were characterized by transmission infrared spectroscopy, X-ray photoelectron...
A web interface to PHYLIP (version 3.57 C) is implemented using CGI/Perl programming. It enables users do phylogenetic analysis through the Internet.
Abstract Introduction Nirogacestat is a targeted gamma secretase inhibitor approved in the United States for adults with progressing desmoid tumors. In phase 3 DeFi study (NCT03785964) of nirogacestat, ovarian toxicity (OT) was identified as safety signal among females reproductive potential (FORP). This analysis further describes incidence, presentation, and resolution OT. Methods Patients were randomized to twice‐daily oral nirogacestat (150 mg) or placebo, taken continuous 28‐day cycles....
Abstract Crosslinking is a ubiquitous strategy in polymer engineering to increase the thermomechanical robustness of solid polymers but has been relatively unexplored context π‐conjugated (semiconducting) polymers. Notwithstanding, mechanical stability key many envisioned applications organic electronic devices. For example, wide‐scale distribution photovoltaic devices incorporating conjugated may depend on integration with substrates subject insult—for road surfaces, flooring tiles, and...
Plastic scintillators based on thermoplastics, such as polystyrene and poly(vinyl toluene) (PVT), are capable of neutron γ radiation detection via pulse shape discrimination (PSD) when overdoped with select fluorescent molecules. This class plastic scintillator has been extensively studied but is limited to applications suitable for thermoplastics. For requiring flexibility, composed elastomers, polysiloxanes, offer an alternative PVT scintillators. Polysiloxane inherently flexible have a...
11558 Background: Nirogacestat (niro) is a targeted and selective gamma secretase inhibitor approved in the US for adults with progressing desmoid tumors (DT). In phase 3 DeFi study, niro demonstrated significant improvement vs placebo (pbo) progression-free survival (PFS: HR, 0.29 [95% CI: 0.15-0.55]; P<.001), objective response rate (ORR: 41% 8%; P<.001); patient-reported outcomes (PROs) of pain, DT-specific symptom burden, physical role functioning, overall quality life ( P≤.01,...
ABSTRACT Poly(vinyl toluene) (PVT) overdoped with 2,5‐diphenyloxazole and using 1,4‐bis(5‐phenyloxazol‐2‐yl)benzene as a fluorescent secondary dopant can be used to detect differentiate neutron gamma radiation via scintillation. The low cost of PVT makes these plastic scintillators attractive for both portable larger sized first line detection special nuclear materials. Current fabrication methods rely on thermally initiated radical polymerization that generally requires an approximately...
The functionality and usability of π-conjugated (semiconducting) polymers is dependent on the adhesive interfacial properties solid film. Such are critical in devices incorporating semiconducting because these layers serve both an active structural role. They load bearing sense that bending, stretching, scratching, impact places stress within film at interfaces with other device stack. Thus, organic semiconductors must have good cohesive despite being designed primarily for optoelectronic...
We report PEDOT:PSS brushes grafted from gold using surface-initiated atom-transfer radical polymerization (SI-ATRP) which demonstrate significantly enhanced mechanical stability against sonication and electrochemical cycling compared to spin-coated analogues as well lower impedances than bare at frequencies 0.1 10
Interest in plastic scintillators for the detection of special nuclear materials (SNMs) has increased recent years due to development systems capable distinguishing between neutron and γ radiation. For example, poly(vinyltoluene) (PVT)-based overdoped with fluorescent small molecule 2,5-diphenyloxazole (PPO) distinguish two types radiation via pulse shape discrimination (PSD). However, PPO overdoping leads softening dopant aggregation, causing major issues efficiency, lifetime, scalability....
11556 Background: Desmoid tumors (DT) are rare, locally aggressive, soft-tissue with a highly unpredictable natural course and substantial patient burden, including pain functional limitations. Prognosis of DT is potentially dependent on multiple factors, tumor location, size, patient’s age, mutational status, presence pain. Nirogacestat (niro), targeted gamma secretase inhibitor, the only treatment approved in US for adults progressing DT. In phase 3 DeFi study, niro demonstrated...
11514 Background: MRI tumor volume or T2 signal intensity changes may represent novel imaging techniques that could have a prognostic predictive value for assessing response in desmoid tumors (DT). For example, hyperintense areas on T2-weighted images been associated with active fibroblastic proliferation and ≥90% hyperintensity is DT disease progression, whereas iso- hypo-intense are inactive sites of disease. In DeFi (NCT03785964), the gamma secretase inhibitor nirogacestat (n=70 patients)...
Plastic scintillators offer a cost-effective and scalable option for detection of special nuclear materials. Traditional plastic are based on thermoplastics such as poly(vinyl toluene) (PVT) polystyrene. When over-doped with select fluorescent molecules, PVT polystyrene capable distinguishing between neutrons gamma ray via pulse shape discrimination (PSD). While this formulation has been extensively studied commercialized, the resulting restricted to applications involving rigid...