A5038862116- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Amoebic Infections and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Parasitic Infections and Diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Malaria Research and Control
- Infectious Diseases and Tuberculosis
- Cancer Treatment and Pharmacology
- Biochemical and Molecular Research
- Parasites and Host Interactions
- Antibiotic Resistance in Bacteria
- Nanotechnology research and applications
- Nanoparticles: synthesis and applications
- Prostate Cancer Treatment and Research
- Antibiotic Use and Resistance
- Synthesis and Catalytic Reactions
- Protein Kinase Regulation and GTPase Signaling
- HIV/AIDS drug development and treatment
- Mass Spectrometry Techniques and Applications
- Heat shock proteins research
Jamia Millia Islamia
2013-2025
Abstract A series of novel 4-((7-chloroquinolin-4-yl)amino)phenyl arenesulfonates were synthesized via a two-step process and characterized by different spectroscopic technique for structural confirmation. The electronic structure these derivatives was investigated Density Functional Theory (DFT), quantum mechanical method. All the evaluated their biological potency. antibacterial activity examined against panel bacteria, but they found to be inactive. Antifungal examination demonstrated...
Antibiotic-resistant bacteria are a serious global health threat, making infections harder to treat and increasing medical costs mortality rates. To combat resistant bacterial strains, series of compounds (QS1-12) were synthesized with an excellent yield 85-92%. Initial assessments these analogues as potential antibacterial agents conducted through preliminary screening against panel diverse strains. The results identified compound QS-3 the most effective candidate, exhibiting exceptional...
Microtubule affinity regulating kinase 4 (MARK4) is a Ser/Thr kinase, considered as potential drug target for cancer, diabetes and neurodegenerative diseases. Due to its significant role in the development progression of different in-house libraries synthesized small molecules were screened identify MARK4 inhibitors. A library hydrazone compounds showed considerable binding MARK4. The selected further scrutinized using an enzyme inhibition assay finally two derivatives (H4 H19) that show...
In an endeavour to develop efficacious antiprotozoal agents chloroquinoline–acetamide hybrids were synthesized and screened <italic>in vitro</italic> against <italic>E. histolytica</italic> <italic>P. falciparum</italic> molecular docking studies performed PfDHFR.
Abstract A series of 2-benzimidazolamine-acetamide derivatives were synthesized by substitution reaction different anilines with chloroacetyl chloride followed the 2-aminobenzimidazole formed substituted chloroacetamides. The structures all compounds elucidated various spectral techniques and evaluated against five bacterial strains. Out ten, N-(2-fluorophenyl)-substituted acetamide displayed better minimum inhibitory concentration (MIC). Disk diffusion assay combination studies also...
Background: The increasing prevalence of antimicrobial resistant highlights the urgent need for new therapeutic agents. This study aimed to design and synthesize fused tricyclic benzimidazole–thiazinone derivatives (CS1–CS10) through a convenient method evaluate their activity against various microorganisms. Methods: A series was rationally designed synthesized in one pot by reaction between trans substituted acrylic acids 1H-benzo[d]imidazole-2-thiol using coupling reagent TBTU...
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In an unremitting search for potential antiprotozoal agents, a series of 2-(3-((2-(2-(quinolin-4-yloxy)acetyl)hydrazineylidene)methyl)-1H-indol-1-yl)acetamide derivatives (QC1-QC11) was designed, synthesized, characterized and evaluated its activities. The anti-amoebic activity these synthesized compounds assessed against the HM1:IMSS strain Entamoeba histolytica. All exhibited good to potent with IC50 values in range 0.36-30.94 µM metronidazole (MTZ) taken as standard (IC50 = 1.8 µM)....
A series of hybrid molecules bearing 5-nitroimidazole linked with substituted piperazine have been synthesized.The cytotoxicity all the synthesized compounds has evaluated on HEK293 cells help MTT assay.It was found that treatment these shows a variable toxicity profile for cells.The results showed in tested concentration range, compound NJ3, NJ5, NJ8 and NJ10 show considerable towards cells.
Breast cancer is most frequently detected and leading cause of death in women worldwide. 80% the breast are estrogen receptor positive presently available drugs ineffective either due to intrinsic resistance or acquired resistance. Sulfonamide compounds a class showing activities like, antibacterial, antiviral including antitumor. In present study we have investigated anti-cancerous activity sulfonamide derivative CID-6861424 on cell line, MCF-7 . Our data shows inhibition viability by...