Quantitative detection of cancer biomarkers with higher accuracy and sensitivity provides an effective platform for screening, monitoring, early diagnosis, disease surveillance. The present work demonstrates the fabrication application fluorescent turn-on biosensor ultrasensitive small cell lung biomarker utilizing biofunctionalized graphene quantum dots as energy donor gold nanoparticles (AuNPs) acceptor. One-pot bottom-up hydrothermal route have been employed synthesis in situ...

Abstract Nanoparticles and their composites are considered to play a significant role in the development of electrochemical biosensors. In present work, we have synthesized titanium dioxide (TiO 2 ) nanoparticles comprising poly (3‐hexylthiophene) (PHT) nanohybrid for fabrication glucose biosensor. The thin film hybrid PHT/TiO nano‐composite was deposited onto indium‐tin‐oxide (ITO) glass substrate followed by immobilization oxidase (GOx). developed sensor characterized using X‐Ray...

Graphene quantum dots (GQDs) are one of the most promising luminescent carbon derived nanomaterials decorated with multiple useful functional groups and remarkable optoelectronic properties. Heteroatom doping hexagonal sheet GQDs is an effective strategy to tailor their properties meet desired application. In this work, sulfur doped (S-GQDs) were synthesized by simply pyrolyzing citric acid (CA) as a source 3-Mercaptopropionic dopant. The optimal reaction conditions (ratio dopant source,...

This review summarizes the recent progress in synthetic, functional, structural and property control strategies of GQDs their current potential applications biomedical optoelectronic domain.

In this work, a new nanocomposite (Ag@S-GQDs) have been synthesized using one-step facile synthesis process and their antibacterial as well cytotoxicity properties were investigated systematically.

Pictorial representation of various topics discussed in the review: GQDs synthesis strategies, properties, their regulation through heteroatom doping/surface functionalization, and (bio)analytical sensors (optical, ECL, electrochemical).

Abstract In this work, we report, the synthesis of Boron and Sulfur co-doped graphene quantum dots (BS-GQDs) its applicability as a label-free fluorescence sensing probe for highly sensitive selective detection dopamine (DA). Upon addition DA, intensity BS-GQDs were effectively quenched over wide concentration range DA (0–340 μM) with an ultra-low limit 3.6 μM. The quenching mechanism involved photoinduced electron transfer process from to dopamine-quinone, produced by oxidization under...

The development of a straightforward, economical, portable, and highly sensitive sensing platform for the rapid detection cholesterol is desirable early diagnosis several pathologic conditions. In this work, we present fascinating skin-worn microneedle sensor monitoring in interstitial fluid samples. was developed by incorporating platinum (Pt) silver (Ag) wires within pyramidal microneedles containing microcavity opening; oxidase (ChOx) coupled on Pt transducer surface using bovine serum...

Recent advances in noninvasive portable and wearable biosensors have attracted significant attention due to their capability offer continual physiological information for continuous healthcare monitoring through the collection of biological signals. To make collected data understandable improve efficacy these biosensors, scientists integrated machine learning (ML) with analyze large sensing various ML algorithms. In this article, we highlighted recent developments ML-enabled biosensors....

The programmed fabrication of oral dosage forms is associated with several challenges such as controlled loading and disintegration. To optimize the drug payload, excipient breakdown, site-specific sustained release hydrophobic (sulfamethoxazole, SM), we propose development acrylate polymer tablets enclosed drug-loaded polycaprolactone (PCL) films. active pharmaceutical ingredient (API) physisorbed into porous iron (Fe)-based metal-organic framework (MOF) later converted to tangible PCL...

Abstract Conventional diagnostic platforms often lack point-of-care, simple, economical, prompt and personalized detection features, whereas nanomaterial-supported intelligent biosensors belonging to the 5th/6th generation are vital vectors in medical diagnostics. The tunable enhanced physicochemical properties of nanomaterials such as surface area, chemistry, band gap, flexibility, nano-biosensors exhibit high sensitivity, specificity, accurate detection. Despite substantial research an...

Abstract The development of an analytical probe to monitor highly mutagenic picric acid (PA) carries enormous significance for the environment and health. A novel, simple rapid fluorescence assay using sulfur‐doped graphene quantum dots (SGQDs) was designed sensitive selective detection PA. SGQDs were synthesized via pyrolysis 3‐mercaptopropionic citric characterized advanced techniques. Fluorescence intensity (FI) markedly quenched by addition PA, attributed inner filter effect dominating...

During the γ-radiation sterilization process, levels of radiation exposure to a medical device must be carefully monitored achieve required without causing deleterious effects on its intended physical and chemical properties. To address this issue, here we have demonstrated development an all-printed disposable low-cost sensor that exploits change in electrical impedance semi-interpenetrating polymer network (SIPN) composed poly(vinyl alcohol) (PVA)...

We report a unique photoanode architecture involving TiO2, g-C3N4, and AuNPs wherein synergistic enhancement of the photoelectrochemical (PEC) performance was obtained with photocurrent densities as high 3 mA cm-2 under AM1.5G 1 sun illumination. The PEC highly stable reproducible, photoresponse down to photon energy 2.4 eV, close interband damping threshold Au. maximized when Au plasmon band strongly overlapped g-C3N4 emission band. Our architecture, which involved buried TiO2...

Cellular tight junctions play a key role in establishing barrier between different compartments of the body by regulating selective passage solutes across epithelial and endothelial tissues. Over past decade, significant efforts have been conducted to develop more clinically relevant "organ-on-a-chip" models with integrated trans-epithelial electrical resistance (TEER) monitoring systems help better understand fundamental underpinnings tissue physiology upon exposure substances. However,...

Conductive polymers and their composite materials have attracted considerable interest due to potential applications in sensors, actuators, drug delivery systems, energy storage devices. Despite wide range of applications, many challenges remain primarily with respect the complex synthesis time-consuming manufacturing steps that are often required fabrication process various devices conductive polymers. Here, we demonstrate novel use cold atmospheric plasma (CAP)-assisted deposition...

A new type of heavy-metal free single-element nanomaterial, called sulfur quantum dots (SQDs), has gained significant attention due to its advantages over traditional semiconductor QDs for several biomedical and optoelectronic applications. straightforward rapid synthesis approach preparing highly fluorescent SQDs is needed utilize this nanomaterial technological Until now, only a few approaches have been reported; however, these are associated with long reaction times low yields (QY)....