A5018966174- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Biomedical Ethics and Regulation
- scientometrics and bibliometrics research
- Regional Development and Policy
- Pharmaceutical industry and healthcare
- Innovation Policy and R&D
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical studies and practices
- Regional Economics and Spatial Analysis
- Biosimilars and Bioanalytical Methods
- Innovation and Knowledge Management
- CAR-T cell therapy research
- Spatial and Panel Data Analysis
- Pluripotent Stem Cells Research
- Biomedical and Engineering Education
- Blood Pressure and Hypertension Studies
- Business Strategy and Innovation
- Economic and Financial Impacts of Cancer
- Pharmaceutical Quality and Counterfeiting
- Academic Publishing and Open Access
- Renin-Angiotensin System Studies
- International Science and Diplomacy
- Entrepreneurship Studies and Influences
- Environmental Toxicology and Ecotoxicology
Utrecht University
2016-2025
Pharmo Institute
2016-2021
Pharmac
2020
Hospital Universitario Puerta de Hierro Majadahonda
2018
University of Applied Sciences Utrecht
2017
University Medical Center Groningen
2012-2014
University of Groningen
2012-2014
Eindhoven University of Technology
2010-2011
We analyse inter-regional research collaboration as measured by scientific publications and patents with multiple addresses, covering 1316 NUTS3 regions in 29 European countries. The estimates of gravity equations show the effects geographical institutional distance on collaboration. also find evidence for existence elite structures between excellence capital regions. results suggest that current EU science policy to stimulate is legitimate, but doubt compatibility cohesion policy.
Following the start of World Health Organization (WHO) Programme for International Drug Monitoring (PIDM) by 10 member countries in 1968, it took another 24 years first two African to join 1992, which time number PIDM had grown 33. Whilst pharmacovigilance (PV), including submission individual case safety reports (ICSR) VigiBase(®), WHO global ICSR database, is growing Africa, no data have been published on growth reporting from Africa and how features ICSRs compare with rest world (RoW).The...
Advanced therapy medicinal products (ATMPs) hold promise as treatments for previously untreatable and high-burden diseases. Expectations are high active company pipelines observed, yet only 10 market authorizations were approved in Europe. Our aim was to identify challenges experienced European ATMP clinical development by companies. A survey-based cohort study conducted among commercial developers. Respondents shared during various phases, well developer product characteristics....
This paper analyzes the factors underlying university research performance as indicated by number of highly-cited publications, international co-publications, and university-industry co-publications. The three indicators evaluate possible missions, respectively: excellence, internationalization, innovation. Using a regression analysis, we assess to what extent university's is influenced structural variables including size, age, city location in capital city, disciplinary orientation, country...
The Framework Programmes (FPs) funded by the European Commission support transnational research collaborations in order to make Research Area more competitive. Some have raised concerns that FPs compromise cohesion policies of aimed at reducing income disparities between regions. We investigate whether existing scientific Union (EU) subnational regions—as captured co-authored publications—are conducive for acquiring FP funding, and turn, stimulates subsequent co-publication activity pairs EU...
Conditional marketing authorization (CMA) in the European Union (EU) is an early access pathway for medicines that show promising therapeutic effects, but which comprehensive data are not available. Using a mixed quantitative-qualitative research design, we evaluated how CMA has been used of oncology period 2006 to 2013. We compared full authorization, granted based on less data. However, this accompanied by significantly longer assessment times and consensus among regulators about...
Aim The aim of the present study was to provide an insight into characteristics and follow‐up postmarketing studies medicines that were conditionally authorized in European Union (EU). Methods We compiled a list all attached as specific obligations licence granted conditional marketing authorization from January 2006 April 2014. Studies characterized based on their objective, design, status upon (MA) due data set by authorities. They linked online registrations ( Clinicaltrials.gov , ENCePP)...
Recent technical and clinical advances with cell-based therapies (CBTs) hold great promise in the treatment of patients rare diseases those high unmet medical need. Currently majority CBTs are developed manufactured specialized academic facilities. Due to small scale, unique characteristics specific supply chain, CBT manufacturing is considered costly compared more conventional medicinal products. As a result, biomedical researchers clinicians increasingly faced cost considerations...
National pharmacovigilance centres (national centres) are gradually gaining visibility as part of the healthcare delivery system in Africa. As does happen high-income countries, it is assumed that national can play a central coordinating role their (PV) systems. However, there no studies have investigated whether Africa sufficient organizational capacity to deliver on this mandate and previous reported challenges such lack funding, political will adequate human resources. We conducted...
Background Pharmaceutical trials are mainly initiated by sponsors and investigators in the United States, Western Europe Japan. However, more patients enrolled Central Eastern Europe, Latin America Asia. The involvement of new geographical settings raises questions about scientific ethical integrity, especially when experience with those is lacking at level trial management. We therefore studied to what extent shift patient enrolment anticipated composition management teams using author...
Scientific breakthroughs are commonly understood as discoveries that transform the knowledge frontier and have a major impact on science, technology, society. Prior literature studying generally treats them homogeneous group in attempts to identify supportive conditions for their occurrence. In this paper, we argue there different types of scientific breakthroughs, which differ disciplinary occurrence associated with considerations use citation patterns. We develop typology based three...
A recent phase II clinical trial (Reducing Residual Albuminuria in Subjects with Diabetes and Nephropathy AtRasentan an identical Japan (RADAR/JAPAN)) showed that the endothelin receptor antagonist atrasentan lowers albuminuria, blood pressure, cholesterol, hemoglobin, increases body weight patients type 2 diabetes nephropathy. We previously developed algorithm, Parameter Response Efficacy (PRE) score, which translates short-term drug effects into predictions of long-term on outcomes. used...
Innovation within companies is generated by a combination of different types knowledge from external and geographically dispersed sources. Although the geographical dimension collaboration has previously been investigated, studies have not distinguished between involved in collaboration. This article analyses how number collaborations pharmaceutical multinational (MNCs) organizations affected distance, distinguishing four types: basic science, clinical core knowledge, exploration knowledge....
Given the need to reduce animal testing for environmental risk assessment, we aim develop a fish invitrome, an alternative modular framework capable of predicting chemical toxicity in without use animals. The central module is validated RTgill-W1 cell line assay that predicts acute chemicals (Organization Economic Cooperation and Development Test Guideline (OECD TG) 249). Expanding towards prediction chronic toxicity, invitrome includes two other well-advanced modules...