A5033120187- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Gut microbiota and health
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory mediators and NSAID effects
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- Reproductive System and Pregnancy
- Organ Transplantation Techniques and Outcomes
- Oral Health Pathology and Treatment
- ATP Synthase and ATPases Research
- Liver Diseases and Immunity
- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
Guangdong Academy of Medical Sciences
2019-2022
Guangdong General Hospital
2022
Guangdong Provincial People's Hospital
2019-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Southern Medical University
2021
Background Imbalance of oral salivary microbiota has been linked to the pathogenesis a variety systemic diseases, and bacterial species have shown be useful biomarkers for diseases.This study aimed characterize alterations in patients with esophageal squamous cell carcinoma (ESCC) evaluate diagnostic performance microbial ESCC. Methods The relative abundance flora saliva samples was analyzed by 16S rDNA sequencing, differences present from ESCC healthy controls (HCs) were identified...
The aim is to explore the predictive value of salivary bacteria for presence esophageal squamous cell carcinoma (ESCC). Saliva samples were obtained from 178 patients with ESCC and 101 healthy controls, allocated screening verification cohorts, respectively. In phase, after saliva DNA was extracted, 16S rRNA V4 regions amplified by polymerase chain reaction (PCR) high-throughput sequencing. Highly expressed target screened Operational Taxonomic Units clustering, species annotation microbial...
Pancreatic cancer (PC), as a highly malignant and aggressive solid tumor, is common in the digestive system. The acidic microenvironment one of critical markers cancer. Nonetheless, there are few studies on how affects development PC. This study focused investigating specific molecular mechanisms In our study, qRT-PCR was conducted for examining microRNA (miR)-451a myocyte enhancer factor 2D (MEF2D) expressions PANC-1 cells. Then, detailed functional effects an environment miR-451a MEF2D...
Objective To study the effect of mycophenolic acid(MPA)on maturation, endocytotic capacity and allostimulatory properties human myeloid dendritic cell ( MDC ). Methods The peripheral blood mononuclear cells were isolated freshly from healthy volunteers (n = 15). group was treated by MPA. Co-stimulatory adhesion molecular on analyzed flow cytometry. After isolation antigen-1 + BDCA-1 ), cellular uptake FITC-dextran measured mixed lymphocyte reaction, percentage allogenic CD+4 T in G0 phase...
Objective To investigate the effect and mechanism of FTY720 on acute graft versus host disease (GVHD) in rat small bowel transplantation (SBTx).Methods Heterotopic SBTx was performed using a parent (WF)-into-F1 (WFxACI)rat combination.Recipient rats were divided into experimental group (n=6) control group(n=6).Rats administered with at 0.5 mg/kg for 14 days.Lymphocyte apoptosis liver mucosa intestine detected by TUNEL flow cytometry 15 days after transplantation.Recipient survival lymphocyte...