A5026499419- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Cardiovascular Syncope and Autonomic Disorders
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Blood Pressure and Hypertension Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Heart Rate Variability and Autonomic Control
Karolinska University Hospital
2015-2017
Karolinska Institutet
2013-2017
Gävle Hospital
2013-2017
Innsbruck Medical University
2008
Universität Innsbruck
2008
Background HIV-1 subtype B (HIV-1B) still dominates in resource-rich countries but increased migration contributes to changes the global distribution. Also, spread of non-B subtypes within such occurs. The trend distribution from beginning epidemic country has earlier not been reported detail. Thus primary objective this study is describe temporal Sweden over three decades. Methods pol sequences patients (n = 3967) diagnosed 1983– 2012, corresponding >40% ever diagnosed, were re-subtyped...
Background Successful treatment reduces morbidity, mortality and transmission of HIV. We evaluated trends in the status HIV infected individuals enrolled care Sweden Denmark during years 1995-2010. Our aim was to assess proportion HIV-infected who received services along continuum 2010, discuss findings relation organization health system. Methods analyzed CD4 counts viral loads (VL) among all patients cohort. For each month study period we estimated proportions 1) had initiated highly...
Objective Describe trends in antiretroviral treatments and drug resistance mutations among Swedish HIV-patients over time 1997–2011. Methods Treatment histories, viral sequences, demographic clinical data were retrieved from the national database InfCareHIV. All ART-experienced patients included (N = 6537), while tests restricted to those obtained ≥90 days after ART start. This cohort is fully representative for Sweden since covers virtually all diagnosed start of epidemic. Patients grouped...
Background Microbial translocation (MT) contributes to immune activation during HIV and HCV infections. We investigated the kinetics of MT markers anti-HCV anti-HIV treatments, if baseline plasma levels lipopolysaccharide (LPS), binding protein (LBP) soluble CD14 (sCD14) could predict treatment outcome. Methods Plasma from 78 HIV-infected patients was evaluated for LPS, LBP sCD14. The starting (with ongoing antiretroviral (ART) treatment) were categorized into sustained viral responders...
Background As HIV infection needs a lifelong treatment, studying drug therapy duration and factors influencing treatment durability is crucial. The Swedish database InfCareHIV includes high quality data from more than 99% of all patients diagnosed with in Sweden provides unique opportunity to examine outcomes nationwide real world cohort. Methods Adult who started new defined as 3rd agent (all antiretrovirals that are not N[t]RTIs) 2009–2014 100 observations treatment-naive or...
Microbial translocation (MT) contributes to immune activation during HIV-1 infection, and persists after initiation of antiretroviral therapy (ART). We investigated whether levels MT markers are influenced by the use co-trimoxazole (TMP-SMX) in patients. Plasma samples were obtained from HIV-1-infected patients initiating ART with (n=13) or without TMP-SMX prophylaxis. Markers [lipopolysaccharide-binding protein (LBP), lipopolysaccharide (LPS), soluble CD14 (sCD14), intestinal fatty acid...
Diabetes mellitus is becoming increasingly common in sub-Saharan Africa. Autonomic dysfunction contributes to morbidity and mortality diabetic patients. Data on autonomic the African population scarce, no reference values for standardized function tests are available. The aim of this study was establish cut off five easy-to-use cardiovascular that may be suitable resource-poor settings.We recruited 276 healthy individuals, 156 men 120 women, aged > 20 years. Participants were tested (1)...
ObjectivesThe use of the NNRTI rilpivirine in low- and middle-income countries (LMICs) is under debate. The main objective this study was to provide further clinical insights biochemical evidence on usefulness LMICs.
Background Switch from first line antiretroviral therapy (ART) to second-line ART is common in clinical practice. However, there limited knowledge of which extent different reason for switch are associated with differences long-term consequences and sustainability the second ART. Material methods Data 869 patients 14601 visits between 1999–2014 were derived national cohort database. Reason viral load (VL) levels at first-line failure compared regard outcome Using Laplace regression model we...