A5021788881- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Pain Management and Treatment
- Botulinum Toxin and Related Neurological Disorders
LivaNova (United States)
2017-2025
University of Alabama at Birmingham Hospital
2024
University of Utah
2024
Northwestern University
2024
Ghent University Hospital
2024
Mayo Clinic in Florida
2024
University of South Florida
2024
University of Alabama at Birmingham
2024
Cornell University
2024
Duke University Hospital
2024
The Automatic Stimulation Mode (AutoStim) feature of the Model 106 Vagus Nerve (VNS) Therapy System stimulates left vagus nerve on detecting tachycardia. This study evaluates performance, safety AutoStim during a 3-5-day Epilepsy Monitoring Unit (EMU) stay and long- term clinical outcomes device stimulating in all modes.The E-37 protocol (NCT01846741) was prospective, unblinded, U.S. multisite AspireSR(®) subjects with drug-resistant partial onset seizures history ictal VNS Normal Magnet...
Electrical stimulation of the cervical vagus nerve using implanted electrodes (VNS) is FDA-approved for treatment drug-resistant epilepsy, treatment-resistant depression, and most recently, chronic ischemic stroke rehabilitation. However, VNS critically limited by unwanted nearby neck muscles-a result non-specific activating motor fibers within vagus. Prior studies suggested that precise placement small epineural can modify therapeutic effects, such as cardiac responses. it remains unclear...
Objectives The most widely used and studied neurostimulation procedure for medically refractory epilepsy is vagus nerve stimulation (VNS) Therapy. goal of this study was to develop a computational model improved understanding the anatomy neurophysiology as it pertains principles electrical stimulation, aiming provide clinicians with systematic rational VNS Materials methods Computational modeling allows peripheral nerves. We finite element electric field models Therapy electrodes calculate...
Abstract Objective In parallel to standard vagus nerve stimulation (VNS), microburst delivery has been developed. We evaluated the fMRI‐related signal changes associated with and optimized in a proof‐of‐concept study (NCT03446664). Methods Twenty‐nine drug‐resistant epilepsy patients were prospectively implanted VNS. Three 3T fMRI scans collected 2 weeks postimplantation. The maximum tolerated VNS intensity was determined prior each scan starting at 0.125 mA increments. FMRI block‐design...
BackgroundVagus nerve stimulation (VNS) at low frequencies (≤30 Hz) has been an established treatment for drug-resistant epilepsy (DRE) over 25 years.ObjectiveTo examine the initial safety and efficacy performance of investigational, high-frequency (≥250 VNS paradigm herein called "Microburst VNS" (μVNS). μVNS consists short, bursts electrical pulses believed to preferentially modulate certain brain regions.MethodsThirty-three (33) participants were enrolled into exploratory feasibility...
Abstract Objective Microburst vagus nerve stimulation (μVNS) may reduce seizure frequency in drug‐resistant epilepsy (DRE) via targeted thalamic plasticity. We prospectively investigated the role of resting‐state functional connectivity (rsFC) μVNS effects and hypothesized a relationship between rsFC long‐term changes. Methods Eighteen patients with focal (Foc) 10 generalized (Gen) DRE underwent 3T fMRI at 2 weeks post‐implantation before starting (baseline) after 6 months μVNS....
The goal of this work is to objectively evaluate the effectiveness responsive (or closed-loop) Vagus nerve stimulation (VNS) therapy in sleep quality patients with medically refractory epilepsy.Using quantitative features obtained from electroencephalography, we first developed a new automatic sleep-staging framework that consists multi-class support vector machine (SVM) classification, based on decision tree approach. To train and performance framework, used polysomnographic data 23 healthy...
Abstract Electrical stimulation of the cervical vagus nerve using implanted electrodes (VNS) is FDA-approved for treatment drug-resistant epilepsy, treatment-resistant depression, and most recently, chronic ischemic stroke rehabilitation. However, VNS critically limited by unwanted nearby neck muscles – a result non-specific activating motor fibers within vagus. Prior studies suggested that precise placement small epineural can modify therapeutic effects, such as cardiac responses. it...
<h3>SUMMARY:</h3> Vagus nerve stimulation devices are conditionally approved for MR imaging with turned off, and the requirement to modify settings may be a barrier scanning in some radiology practices. There is increasing interest studying effects of during imaging/fMRI. This study evaluated safety standard investigational microburst vagus therapies A prospective, multicenter was conducted patients an device that delivered either or stimulation. Thirty participants underwent sequential fMRI...
To investigate effects of microburst vagus nerve stimulation (μVNS) on resting-state functional connectivity (rsFC) in treatment resistant epilepsy (TRE).