A5005339910- Cancer Cells and Metastasis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Magnolia and Illicium research
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Chemical Reactions and Isotopes
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Oxidative Organic Chemistry Reactions
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Curcumin's Biomedical Applications
- Phytochemical Studies and Bioactivities
- 14-3-3 protein interactions
- Hedgehog Signaling Pathway Studies
- Cancer, Lipids, and Metabolism
- Genomics and Chromatin Dynamics
SRM Institute of Science and Technology
2017-2025
The University of Kansas Cancer Center
2012-2021
University of Kansas Medical Center
2011-2021
Chettinad Academy of Research and Education
2016-2018
SRM University
2017
University of Kansas
2011-2015
University Medical Center
2011-2013
University Hospital and Clinics
2011-2013
Lanzhou University Second Hospital
2012
Lanzhou University
2012
Nanotechnology is an embryonic field that grips countless impacts on the drug delivery system. Nanoparticles as haulers increase capability of target-specific to many folds hence are used in treatment dreadful diseases such cancer, diabetes, etc. This boom has aimed at, synthesize Copper oxide nanoparticles (CuO-NPs) using Acalypha Indica leaf extract and then incorporated with graphene (GO) form GO-CuO nanocomposites. Secondly, sightsee photocatalytic activity CuO-NPs nanocomposites towards...
Abstract Cancer stem cells are implicated in resistance to ionizing radiation (IR) and chemotherapy. Honokiol, a biphenolic compound has been used traditional Chinese medicine for treating various ailments. In this study, we determined the ability of honokiol enhance sensitivity colon cancer IR. The combination IR suppressed proliferation colony formation while inducing apoptosis culture. There were also reduced numbers size spheroids, which was coupled with expression cell marker protein...
CUGBP2, a translation inhibitor, induces colon cancer cells to undergo apoptosis. Mcl-1, an antiapoptotic Bcl-2 family protein, interferes with mitochondrial activation inhibit Here, we have determined the effect of CUGBP2 on Mcl-1 expression. We developed HCUG2 cell line by stably expressing in HCT-116 cells. demonstrate decreased levels proliferation and increased apoptosis, compared Flow cytometry analysis demonstrated higher G 2 -M phase. Western blot analyses that there was protein but...
Background Curcumin inhibits the growth of pancreatic cancer tumor xenografts in nude mice; however, mechanism action is not well understood. It becoming increasingly clear that RNA binding proteins regulate posttranscriptional gene expression and play a critical role stability translation. Here, we have determined curcumin modulates protein CUGBP2 to inhibit growth. Methodology/Principal Findings In this study, show treated significant reduction volume angiogenesis. inhibited proliferation,...
// Parthasarathy Rangarajan 2 , Dharmalingam Subramaniam Santanu Paul 1 Deep Kwatra Kanagaraj Palaniyandi Shamima Islam Sitaram Harihar Satish Ramalingam William Gutheil 3 Sandeep Putty Rohan Pradhan 4 Subhash Padhye Danny R. Welch 1, Shrikant Anant Animesh Dhar Department of Cancer Biology, University Kansas Medical Center, City, KS, USA Molecular and Integrative Physiology, Pharmaceutical Sciences, Missouri at MO, Interdisciplinary Science Technology Research Academy, Abeda Inamdar...
Abstract Metastasis is a major cause of cancer-related deaths. A dearth preclinical models that recapitulate the metastatic microenvironment has impeded development therapeutic agents are effective against disease. Because majority solid tumors metastasize to lung, we developed multicellular lung organoid mimics with air sac–like structures and production surfactant protein. We used these cultures, called primitive lung-in-a-dish (PLiD), recreate disease using primary established cancer...
Abstract Colorectal cancer is one of the common cancers worldwide and second leading cause cancer-related death. The current treatment has inherent drawbacks there a need developing new treatment. Interleukin-6 pleiotropic cytokine involved in immune regulation activation JAK2/STAT3 pathway colorectal cancer. signaling functions as critical regulator cell growth, differentiation, expression. abnormality tumorigenesis colon including apoptosis. In this study, we identified novel inhibitors...
Colon cancer is the third leading cause of death in both men and women United States. Every year, 160000 cases colorectal are diagnosed, 57000 patients die. CUGBP, Elav-like family member 2 (CELF2) an RNA binding protein that modulates various posttranscriptional events including splicing, shuttling, editing, stability translation. Previous studies have demonstrated CELF2 expression low colon cells. Furthermore, ectopic overexpression induces cells to undergo by mitotic catastrophe. Based on...
Abstract: MicroRNAs (miRNAs) are a class of noncoding RNAs that regulate gene expression in cancer cells and Cancer Stem Cells (CSCs), play an indispensable role the development resistance to radiotherapy chemotherapy treatment. The dysregulation miRNAs CSCs plays vital influencing features their mechanisms different forms cancer. These also engaged regulating important signaling pathways, such as Notch Wnt, which have impact on behavior response intricate network interactions with essential...
Background: Breast cancer (BC) is a common malignancy that poses serious threat to women's health. The hypoxic tumor microenvironment in BC promotes drug resistance, making hypoxia-targeted therapies crucial. Targeting hypoxia-inducible factors (HIFs), particularly HIF-2α, has emerged as promising approach inhibit growth and improve response chemotherapy radiotherapy. However, further research required fully understand the role of HIF-2α develop more effective treatments for BC. Aim: aim...
Abstract: RNA-binding proteins (RBPs) regulate gene expression at the post-transcriptional level and are important factors in cancer progression response to various therapeutic strategies. Radioresistance, an obstacle caused due intrinsic extrinsic factors, remains a major hindrance treatment of could lead tumor recurrence. Though research is being conducted on cause association radioresistance with cellular environmental there much be explored discovered. The roles several metastasis well...