A5079405785- Renal Diseases and Glomerulopathies
- Telomeres, Telomerase, and Senescence
- Phytochemicals and Medicinal Plants
- Vasculitis and related conditions
- Cancer Research and Treatments
- Renal and related cancers
- Advanced Welding Techniques Analysis
- Alkaline Phosphatase Research Studies
- Microstructure and mechanical properties
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Parathyroid Disorders and Treatments
- Cancer Cells and Metastasis
- Additive Manufacturing Materials and Processes
- Chronic Kidney Disease and Diabetes
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Andrographolide Research and Applications
- Cancer Mechanisms and Therapy
- Parvovirus B19 Infection Studies
- PI3K/AKT/mTOR signaling in cancer
- Autoimmune Bullous Skin Diseases
- Biomedical Research and Pathophysiology
- Trace Elements in Health
- MicroRNA in disease regulation
Post Graduate Institute of Medical Education and Research
2013-2024
Maharishi Markandeshwar University, Mullana
2024
University of Mumbai
2023-2024
Chandigarh University
2024
Institute of Post Graduate Medical Education and Research
2023
University of Louisville
2012-2018
Materials Design (France)
2015
Jadavpur University
2012
Indian Institute of Technology Madras
2005
Selective laser melting (SLM) is an additive manufacturing (AM) process in which parts are fabricated by selectively regions of the surface a metallic powder bed layer-by-layer fashion. Various thermal phenomena such as heat conduction, convection, radiation, and solidification, dynamic phase changes, evaporation occur during SLM process. In addition, intensity scan speeds processing complicate understanding due to complex interactions between laser. order study these interactions, finite...
Telomere binding factors viz. TRF1 and TRF2 are a part of sheltrin complex that present exclusively at the ends chromosomes. These play an important role in maintaining chromosomal integrity ends. However, their status not clear renal cell carcinoma (RCC). Therefore, study was conducted to evaluate expressions RCC tissues. Further, these involved tumorigenesis elucidated by gene silencing using siRNA line (A498). The documented significant over-expression (P = 0.005) 0.0048) mRNAs real time...
We have previously reported that high aldehyde dehydrogenase (ALDH) enzyme activity in breast cancer cells results stem cell (BCSC) properties by upregualting Notch‐1 and epithelial mesenchymal markers. This chemoresistance cancer. Here, we examined the functional clinical significance of ALDH expression measuring levels tissues immunohistochemistry. There was a significantly higher grade tumor (Grade‐ II III) versus normal tissues. Injection BCSC (ALDH + CD44 /CD22 − ) resulted aggressive...
// Suman 1 , Trinath P. Das Jim Moselhy Deeksha Pal Venkatesh Kolluru Houda Alatassi 2 Murali K. Ankem Chendil Damodaran Department of Urology, University Louisville, KY, USA Pathology, Correspondence to: Damodaran, email: chendil.damodaran@louisville.edu Keywords: dietary agents, chemoprevention, prostate cancer Received: April 28, 2016 Accepted: June 13, Published: July 20, ABSTRACT We previously reported that withaferin A (WA), a natural compound, deters by inhibiting AKT while inducing...
Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal colon carcinogenesis remain unknown. We investigated the chemopreventive effect WA on transgenic adenomatous polyposis coli (APCMin/+) mouse chemically induced azoxymethane/dextran sodium sulfate (AOM/DSS) models carcinogenesis. Oral administration (4 3 mg/kg) inhibited tumor initiation progression polyps formation in APCMin/+ mice AOM/DSS model. WA-administered showed a significant reduction both...
Cadmium, an established carcinogen, is a risk factor for prostate cancer. Induction of autophagy prerequisite cadmium-induced transformation and metastasis. The ability Psoralidin (Pso), non-toxic, orally bioavailable compound to inhibit prevent cancer was investigated.Psoralidin studied using cadmium-transformed epithelial cells (CTPE), which exhibit high proliferative, invasive colony forming abilities. Gene protein expression were evaluated by qPCR, western blot, immunohistochemistry...
Abstract Epithelial to mesenchymal transition (EMT) in colorectal cancer (CRC) has been attributed activation of AKT and Notch1 signaling pathways. As EMT corresponds increased aggressiveness CRC, approaches that prevent metastasis by targeting AKT/Notch1 pathways are at the forefront current research paradigms. This study examined anti-metastatic potential Verrucarin J (VJ), a small molecule, CRC cells overexpressing Notch1. VJ significantly inhibited AKT/HCT 116 cell growth acting on...
The activation of AKT governs many signaling pathways and promotes cell growth inhibits apoptosis in human malignancies including prostate cancer (CaP). Here, we investigated the molecular association between function death-associated protein kinase 3 (DAPK3) CaP. An inverse correlation pAKT DAPK3 expression was seen a panel CaP lines. Inhibition by wortmannin/LY294002 or overexpression reverts proliferative cells. On other hand, ectopic inhibited induced proliferation In addition,...
A novel dislocation density based crystal plasticity finite element model (DDCP-FEM) framework has been extended to predict subgrain formation during ultrasonic additive manufacturing of Al 3003 H-18 tempered foils. The present study identifies various microstructural transitions such as recrystallization and evolutions that occur the processing these foils a function input parameters normal force, oscillation amplitude, initial microstructure. Furthermore, changes in average grain sizes...
Abstract In this paper, we present a detailed statistical analysis related to the characterization of spatial and temporal fluctuations in rainfall patterns North-East region ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:msup> <mml:mrow/> <mml:mo>∘</mml:mo> </mml:msup> <mml:mtext>N</mml:mtext> </mml:mrow> </mml:math> –26.95 , <mml:mn>88.05</mml:mn> <mml:mstyle scriptlevel="0"/> <mml:mi mathvariant="normal">E</mml:mi> –94.95...
Malware detection plays a critical role in securing endpoints such as workstations, servers, cloud instances, and mobile devices. It involves identifying mitigating malicious activities triggered by various forms of malware, including viruses, trojans, worms, ransomware, adware, spyware. With the rapid proliferation sophisticated evasive malware variants, polymorphic metamorphic traditional signature-based heuristic approaches are no longer sufficient. These conventional methods often fail...