A5035086825- Pediatric Pain Management Techniques
- Infant Development and Preterm Care
- Family and Patient Care in Intensive Care Units
- Anesthesia and Pain Management
- Healthcare professionals’ stress and burnout
- Hemoglobinopathies and Related Disorders
- Prenatal Substance Exposure Effects
- Maternal Mental Health During Pregnancy and Postpartum
- HIV Research and Treatment
- Childhood Cancer Survivors' Quality of Life
- Perfectionism, Procrastination, Anxiety Studies
- Family Support in Illness
- Anesthesia and Sedative Agents
- Pharmacogenetics and Drug Metabolism
- Family and Disability Support Research
- Immune Cell Function and Interaction
- Pharmacological Effects and Toxicity Studies
- Food Security and Health in Diverse Populations
- Adolescent and Pediatric Healthcare
- COVID-19 and Mental Health
- Emergency and Acute Care Studies
- Gestational Diabetes Research and Management
- Infant Health and Development
- Ecology and Vegetation Dynamics Studies
- Child and Adolescent Psychosocial and Emotional Development
University of California, Irvine
2009-2025
Children's Hospital of Orange County
2021-2025
Virginia Commonwealth University
2022-2025
German Centre for Integrative Biodiversity Research
2024
Helmholtz Centre for Environmental Research
2024
University of California, Los Angeles
2012-2023
University of Rochester
2023
University of Utah
2023
University Hospitals of Cleveland
2023
University of Pittsburgh
2022
OBJECTIVES & AIM: The purpose of this investigation was to examine children's anxiety across the perioperative setting.Although several studies have examined preoperative in children, few researchers illustrated anxiety; that is, children throughout pre and postoperative continuum.Participants were 261 ages 2-12. Anxiety rated prior surgery, immediately after for 2 weeks at home following surgery.Low child sociability high parent predicted anxiety. Perioperative related pain negative...
The purpose of this controlled study was to provide a description children's postoperative pain, including pain intensity and analgesic consumption.Participants included 261 children, 2 12 years age, undergoing routine tonsillectomy adenoidectomy surgery. Baseline demographic data were collected before surgery, standardized approach anesthesia surgical procedures used. Pain consumption recorded for weeks at home.On the first day home, although parents rated 86% children as experiencing...
Abstract Ecologists have worked to ascribe function the variation found in plant populations, communities and ecosystems across environments for at least past century. The vast body of research functional ecology has drastically improved understanding how individuals respond their environment, are assembled function. However, with limited exceptions, few studies quantified differences during earliest stages life cycle, fewer tested this early variability shapes ecosystems. Drawing from...
Pediatric laceration repairs are common in the emergency department (ED) and often associated with significant procedural anxiety. Despite increased use of intranasal midazolam (INM) prior to pediatric ED procedures, there is limited, real-world data on effects INM This study aimed describe proportion children who were nonresponsive (i.e., exhibited extreme anxiety) identify factors nonresponse. cross-sectional included a sample 102 (ages 2-10 years) received 0.2 mg/kg repair ED. Procedural...
Certain major histocompatibility complex class I (MHC-I) alleles are associated with delayed disease progression in individuals infected human immunodeficiency virus (HIV) and macaques simian (SIV). However, little is known about the influence of these MHC on acute-phase cellular immune responses. Here we follow 51 animals SIV(mac)239 demonstrate a dramatic association between Mamu-A*01 -B*17 expression slowed progression. We show that dominant cytotoxic T lymphocyte (CTL) responses...
The purpose of this study was to conduct a prospective assessment preoperative anxiety in adolescents undergoing surgery. To systematically multimodal evaluation surgery.The existing literature on children has overwhelmingly ignored the surgical setting, yet may be at risk for undertreatment anxiety.A total 59 aged 11-18 were recruited. Behavioral and physiological manifestations assessed with visual analog scale an ambulatory data recorder that collected heart rate (HR), skin conductance...
Abstract Background Burnout is common among physicians and has detrimental effects on patient care physician health. Recent editorials call attention to perfectionism in medicine; however, no studies date have examined the effect of burnout practicing United States. This study associations demographics, personality traits, physicians. Methods cross-sectional included general pediatric sub-specialist Out 152 contacted, 69 enrolled (Mean age = 44.16 ± 9.98; 61% female). Emotional exhaustion,...
CD8(+) T lymphocytes appear to play a role in controlling human immunodeficiency virus (HIV) replication, yet routine immunological assays do not measure the antiviral efficacy of these cells. Furthermore, it has been suggested that CD8+ cells recognize epitopes derived from proteins expressed early viral replication cycle can be highly efficient. We used functional vitro assay assess abilities different epitope-specific T-cell lines control simian (SIV) replication. compared efficacies 26...
Each year more than 4 million children experience significant levels of preoperative anxiety, which has been linked to poor recovery outcomes. Healthcare providers (HCPs) and parents represent key resources for help them manage their anxiety. The current study reports on the development preliminary feasibility testing a new intervention designed change HCP parent perioperative behaviors that have reported previously be associated with children's coping stress before surgery.An empirically...
Objectives: Sickle cell disease (SCD) pain and hospitalizations increase during adolescence adolescents with SCD may be at-risk for experiencing health-related stigma, which result in poor health outcomes. This study examined relations among interference, social support, quality of life (QOL), hospital outcomes (ie, loneliness, reduction, length stay [LOS]) hospitalized pain. Materials Methods: Twelve- to 18-year-old (N=92) completed measures QOL, state loneliness. Reduction intensity...
Abstract Introductions Sickle cell disease (SCD) is the most commonly inherited blood disorder in United States, and it predominately affects Black community. SCD characterized by a number of symptoms, including unpredictable pain, which can lead to hospitalizations. Data indicate that people with experience racism ample data predicts depressive symptoms impaired health-related quality life (HRQOL). In contrast, research suggests social support might buffer impact on depression. The aim this...
Approximately 70,000 adolescents and young adults (AYA) are diagnosed with cancer each year in the United States. Sarcomas carry a particularly high symptom burden some of most common cancers among AYA. Recent work has documented significant levels unmet needs AYA cancer, need for psychosocial support. Mobile technology may be cost-effective efficient way to deliver intervention survivors.
Epitope-specific CD8+ T lymphocytes may play an important role in controlling human immunodeficiency virus (HIV)/simian replication. Unfortunately, standard cellular assays do not measure the antiviral efficacy (the ability to suppress replication) of lymphocytes. Certain epitope-specific be better than others at suppressing viral We compared two immunodominant lymphocyte responses--Tat(28-35)SL8 and Gag(181-189)CM9--by using a functional vitro assay. Viral suppression by Tat-specific was...
Adenovirus 5 (Ad5) vectors show promise as human immunodeficiency virus vaccine candidates. Indian rhesus macaques vaccinated with Ad5-gag controlled simian-human SHIV89.6P viral replication in the absence of Env immunogens that might elicit humoral immunity. Here we immunized 15 using either a homologous Ad5-gag/Ad5-gag (Ad5/Ad5) or heterologous DNA-gag/Ad5-gag (DNA/Ad5) prime-boost regimen and challenged them high dose simian SIVmac239. Macaques DNA/Ad5 experienced brief load nadir less...
Children experience distress after surgery. Associations exist between parent reassurance (e.g., "It's OK") and child distress, but little is known about the causal direction of these interactions. This study examined sequential relations mothers' fathers' children's distress.146 families with 2- to 11-year-olds undergoing elective surgery participated. Time-event coding time-window analysis whether preceded or followed distress. Secondary analyses relation sex anxiety reassurance/distress...
To assess sleep hygiene and the environment of urban children with without asthma, examine associations among stressors, hygiene, outcomes.
Purpose: The aims of the current study were to better understand, from perspective adolescents and young adults (AYAs) with sarcoma, parents, providers, friendship support needs AYAs bone soft tissue sarcoma role social media in facilitating for sarcoma. Methods: Semistructured interviews conducted 21 participants. AYA (n = 10) ranged age 14 23 years (mean 19.3, standard deviation 3.4 years; 50% female). All reported a or past diagnosis except one patient who had another cancer but was...
Full-length human (hFMO2.1) and monkey (mFMO2) flavin-containing monooxygenase proteins, which share 97% sequence identity, were produced by baculovirus-mediated expression in insect cells assayed for <i>S</i>-oxygenation under conditions known to affect FMO activity. Both enzymes demonstrated maximal activity at pH 9.5; but hFMO2.1 retained significantly more than mFMO2 did 9.0 higher. also the presence of magnesium all detergents tested. Although had residual after heating 45°C mFMO2, some...
Accurate assessment is critical in pediatric pain, and often adults gauge pain via children’s behavior. To measure adults’ gender biases regard to 183 completed measures rated the of a videotaped child receiving finger stick blood test. Half participants were told was male half female. Participants “male” patient as having greater pain. Similarly, participants’ indicated beliefs that girls are more sensitive reactive than boys. Results suggest hold explicit implicit